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CA2 — RELA
Text-mined interactions from Literome
Hsuan et al., Microb Pathog 1999
:
The
role of
Ca2+ and tyrosine kinases in
NF-kappaB activation and inflammatory cytokine gene expression was studied, since an inhibitor of tyrosine kinases attenuates LPS induced [Ca2+ ] i elevation in BAMs
Tando et al., Am J Physiol 1999
(Second Messenger Systems) :
Caerulein induced
NF-kappaB/Rel activation
requires both
Ca2+ and protein kinase C as messengers ... Here, we show that activation of
NF-kappaB/Rel by caerulein, a CCK analog,
requires increasing intracellular
Ca2+ levels and protein kinase C activation
Quinlan et al., J Immunol 1999
(Calcium Signaling) :
The SP-elicited intracellular
Ca2+ signal was
required for activation and subsequent binding of both NF-AT and
NF-kappa B
Takuma et al., Eur J Neurosci 1999
(Reperfusion Injury) :
These findings indicate that
Ca2 + reperfusion induced apoptosis is
mediated at least partly by ROS production and ROS cause
NF-kappaB activation in cultured astrocytes
Morigiwa et al., Nihon Yakurigaku Zasshi 2000
:
Release of cytokines may be induced via
Ca2+ influx and
activation of NFAT,
NF-kappa B or p44/42 and p38 MAP kinases, switching off the mitotic signal transduction pathway and triggering the apoptotic cascade at the same time
Aifantis et al., Nat Immunol 2001
(Calcium Signaling) :
Constitutive pre-TCR signaling promotes differentiation through
Ca2+ mobilization and
activation of
NF-kappaB and NFAT
El Bekay et al., Blood 2003
(Calcium Signaling...) :
Ang II increased cytosolic
Ca2+ levels released mainly from calcium stores enhanced the synthesis de novo and activity of calcineurin, and
stimulated the DNA binding activity of the transcription factor
NF-kappaB in cultured human neutrophils
Miyakawa-Naito et al., J Biol Chem 2003
:
Partial truncation of the NH2 terminus of Na, K-ATPase catalytic alpha1-subunit abolished
Ca2+ oscillations and downstream
activation of
NF-kappaB
Lin et al., J Biol Chem 2004
(Inflammation...) :
Cr3 induces inflammatory cytokine secretion by activating
NF-kappaB and p38 mitogen activated protein kinase in a
Ca2+ dependent manner, but influx by extra-cellular Ca2+ is not involved
Mitsuyama et al., J Bone Miner Res 2004
(Calcium Signaling) :
These results show that the
Ca2+ signaling pathway involving calcineurin regulates IL-8 gene expression through
activation of
NF-kappaB in human osteoblast-like cells
Venkatesha et al., J Biol Chem 2004
:
Furthermore, a
Ca2+/calcineurin inhibitor completely
inhibited PAF induced NFAT activation and CCL2 production but not
NF-kappaB activation
Zhi et al., J Cell Physiol 2006
(Inflammation) :
Moreover, our data shows that SPHK1 is the isoform activated by TNFalpha, and plays an essential role on the TNFalpha triggered intracellular
Ca2+ signals, degranulation, cytokine production, and
activation of
NFkappaB , thus suggesting a pivotal role for SPHK1 on the proinflammatory responses triggered by TNFalpha
Zhou et al., J Biol Chem 2006
:
Therefore, these results revealed the following
roles of
Ca2+ and PKC in the signaling pathway for
NF-kappaB activation in LPS stimulated macrophages
Bair et al., J Biol Chem 2009
(Thrombosis) :
Ca2+ signaling is
involved in
NF-kappaB activation, but the role of store operated Ca2+ entry is unclear
Kang et al., Pharmacol Res 2009
:
Resveratrol suppressed the expression of TNF-alpha, IL-6, IL-8 and COX-2 through a decrease in the intracellular levels of
Ca2+ and ERK 1/2, as well as
activation of
NF-kappaB
Jeon et al., Cell Mol Life Sci 2010
:
Annexin A4 interacts with the NF-kappaB p50 subunit and modulates
NF-kappaB transcriptional activity in a
Ca2+ dependent manner
Jenkins et al., J Immunol 1995
(Leukemia-Lymphoma, Adult T-Cell) :
We show in this work that mutations in either the purine-rich region of the CLEO element or the
NF-kappa B site
result in reduced
PMA/Ca2+ activation of a 620-bp human GM-CSF promoter-luciferase reporter construct in Jurkat T cells by 65 % and 50 %, respectively
Sen et al., FEBS Lett 1996
:
Involvement of intracellular
Ca2+ in oxidant induced
NF-kappa B activation ... In Jurkat cells that are not sensitive to H2O2 induced NF-kappaB activation, H2O2 potentiated
NF-kappaB activation in the
presence of sustained high
[Ca2+ ] i following thapsigargin treatment
Marinovich et al., Exp Cell Res 1996
:
These findings suggest that TPT increases intracellular
Ca2+ , alters actin polymerization and the cytoskeleton, and
induces NF-kappaB activation, TNF-alpha synthesis, DNA degradation, and apoptosis
Pahl et al., FEBS Lett 1996
:
Activation of
NF-kappa B by ER stress
requires both
Ca2+ and reactive oxygen intermediates as messengers ... Consistent with an involvement of calcium, the ER-resident
Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid (CPA), which trigger a rapid efflux of Ca2+ from the ER, also potently
activated NF-kappaB
Pahl et al., Trends Biochem Sci 1997
:
Both the release of
Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are
required for ER-overload mediated
NF-kappa B activation
Ko et al., J Neurochem 1998
:
NMDA treatment also enhanced the DNA binding activity of nuclear
NF-kappaB in a
Ca2+ dependent manner