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ABCA1 — APOB
Text-mined interactions from Literome
Brewer et al., Am J Cardiol 2003
(Coronary Artery Disease) :
Overexpression of
ABCA1 in mice on a regular chow or Western diet results in a marked increase in plasma HDL,
increased LDL , and increased transport of cholesterol to the liver
Li et al., Di Yi Jun Yi Da Xue Xue Bao 2004
(Atherosclerosis) :
The mRNA and protein expression levels of
ABCA1 , ICAM-1 and MCP-1 all
increased after treatments with
Ox-LDL and 8-Br-cAMP
Li et al., J Huazhong Univ Sci Technolog Med Sci 2005
:
In the present study, we examined the
regulation of the expression and function of
ABCA1 by modified
LDL ( ox-LDL ) in vitro
Ko et al., J Lipid Res 2005
(Atherosclerosis) :
A survey of lipid homeostasis in EL+/+ and EL-/- macrophages revealed that oxidized
LDL induced
ABCA1 was attenuated in EL-/- macrophages
Tam et al., Am J Physiol Cell Physiol 2006
:
Consistent with this high apparent affinity, expression of
ABCA1 in human embryonic kidney cells both increased rapid efflux of 25-hydroxcholesterol and
prevented oxysterol mediated repression of
low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl-coenzyme A ( HMG-CoA) reductase mRNAs
Zhou et al., J Biol Chem 2008
(Atherosclerosis...) :
Interestingly, oxidized
LDL induced more
ABCA1 in wild type macrophages than LDLR ( -/- ) cells ...
LDL induced
ABCA1 expression in wild type cells but inhibited it in LDLR ( -/- ) macrophages in a concentration dependent manner
Guan et al., Am J Chin Med 2010
(Atherosclerosis) :
Moreover,
ox-LDL significantly
promoted ABCA1 expression
Tängemo et al., J Lipid Res 2011
(Niemann-Pick Disease, Type C) :
Attenuated lysosomal cholesterol accumulation in `` variant '' cells was associated with detectable NPC1 protein and residual capability to upregulate expression of
ABCA1 in
response to
LDL
Kolouchova et al., J Gastroenterol Hepatol 2011
(Cholestasis...) :
The change was accompanied by the reduced liver expression of Hmg-CoA reductase,
LDL receptor, and Acat2, and
induced the expression of
Abca1 and Mdr2
Ribas et al., Proc Natl Acad Sci U S A 2011
(Atherosclerosis...) :
In isolated macrophages, ERa was necessary for repression of inflammation, maintenance of oxidative metabolism, IL-4 mediated induction of alternative activation, full phagocytic capacity in response to LPS, and oxidized
LDL induced expression of ApoE and
Abca1