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MAP2K5 — TNF

Text-mined interactions from Literome

Manna et al., Biochem Pharmacol 1999 : Beta-lapachone also abolished TNF induced activation of AP-1, c-Jun N-terminal kinase, and mitogen activated protein kinase kinase ( MAPKK or MEK )
Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Manna et al., J Biol Chem 2000 : hCG abrogated the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase required for NF-kappaB and AP-1, respectively
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1, and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Manna et al., J Immunol 2000 : Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation
Akaike et al., Mol Cell Biol 2004 : The dominant negative MEK5beta also prevented flow mediated inhibition of tumor necrosis factor alpha mediated NF-kappaB activation and adhesion molecule expression, including vascular cellular adhesion molecule 1 and E-selectin, indicating a physiological role for ERK5 and PPARgamma activation in flow mediated antiinflammatory effects
Cha et al., J Pharmacol Exp Ther 2006 : The Syk inhibitor also decreased TNFalpha induced mitogen activated protein kinase kinase ( MKK ) 4 phosphorylation but not MKK3 and MKK6 phosphorylation, which is consistent with its selective sparing of p38
Clark et al., Microcirculation 2011 : MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells ... We assessed effects of MEK5/CA on TNF responses using qRT-PCR, FACS and measurements of HDMEC monolayer electrical resistance
Manna et al., J Biol Chem 1998 : In addition, Mn-SOD blocked the TNF mediated activation of activated protein-1, stress activated c-Jun protein kinase, and mitogen activated protein kinase kinase