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GRK7 — OPRM1
Text-mined interactions from Literome
Wang et al., Neuropharmacology 2000
:
These results suggest that homologous desensitization of rat mu-opioid receptors results from the activation of GRK2 and that a cluster of Ser/Thr residues ( Thr354Ser355Ser356Thr357 ) at the intracellular carboxyl tail plays an important role in
GRK2 mediated
mu-opioid receptor desensitization
Carman et al., J Biol Chem 2000
:
Similarly, wild-type GRK2 but not
GRK2 ( K567E/R578E ) or GRK2 ( R587Q )
promoted morphinedependent phosphorylation of the
mu-opioid receptor in cells
Johnson et al., Mol Pharmacol 2006
:
Expression of a dominant negative mutant G protein coupled receptor kinase 2 (
GRK2 ), GRK2-K220R, markedly attenuated the DAMGO induced desensitization of MOR1, but it
had no effect on morphine induced
MOR1 desensitization
Moulédous et al., J Biol Chem 2012
(Neuroblastoma...) :
Using siRNA knockdown we could demonstrate that 1DMe induced Ser-377 cross-phosphorylation and
MOP receptor loss of function were
mediated by the G protein receptor kinase
GRK2 ... These data show that NPFF induced heterologous desensitization of
MOP receptor signaling is
mediated by
GRK2 and could involve transphosphorylation within the heteromeric receptor complex