Gene interactions and pathways from curated databases and text-mining

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MMP14 — ROCK1

Text-mined interactions from Literome

Xue et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008 : Our aim was to test the anticancer effects of Rho/ROCK inhibitor, Y-27632, including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of matrix metalloproteinase ( MMP ) and tumor progression
Ispanovic et al., Am J Physiol Cell Physiol 2008 : ROCK inhibition rapidly increased cell surface localization of MT1-MMP and increased PI3K activity, which was required for MMP-2 activation
Matsuoka et al., Clin Exp Metastasis 2011 (Adenocarcinoma, Scirrhous...) : The effect of ROCK inhibitor, Y-27632 on the mRNA expression of the integrin family and MMP in gastric carcinoma cells was subsequently examined by Reverse transcriptional ( RT ) -PCR analysis ... ROCK inhibitor also enhanced the invasion of OCUM-2MD3 cells through matrigel and the expression of membrane-type 1 matrix metalloproteinase ( MT1-MMP )