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PHKA2 — TYR

Text-mined interactions from Literome

Shiota et al., Mol Endocrinol 2003 : Although p190 RhoGAP is tyrosine phosphorylated by c-Src via the tyrosine kinase Pyk2, wild-type PTP20 had little effect on p-Tyr418 of c-Src and no effect on p-Tyr402 of Pyk2 , which are required for full c-Src activity and for interacting between Pyk2 and c-Src, respectively
Meyer et al., J Biol Chem 2004 : In the presence of activated FGFR3, the activation of Pyk2 itself became independent of Tyr ( 402 ), indicating that FGFR3 activation circumvents the requirement for c-Src recruitment at Tyr ( 402 ) of Pyk2
Butler et al., J Biol Chem 2005 : Pyk2 binding to the beta ( 3 ) cytoplasmic tail is direct and dependent upon Pyk2-Tyr-402 and beta ( 3 ) -Tyr-747 phosphorylations
Le Boeuf et al., Mol Biol Cell 2006 : Interestingly, ROCK mediated phosphorylation of Ser732 is essential for Pyk2 dependent phosphorylation of Tyr407 , because the latter is abrogated in cells expressing a FAK mutant that is nonphosphorylatable on Ser732