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ANGPT1 — NOS3

Text-mined interactions from Literome

Chen et al., J Appl Physiol 2004 : Thirty minutes of pretreatment of cells with either 1 microg/ml geldanamycin ( a specific inhibitor of HSP90 ) or 500 nM wortmannin [ a specific phosphatidylinositol 3 (PI3)-kinase ( PI3K ) inhibitor ] significantly attenuated Ang-1 stimulated eNOS phosphorylation and NO production ... We conclude that stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to Ang-1 induced eNOS phosphorylation, NO production, and angiogenesis in PCAEC
Bitto et al., Clin Sci (Lond) 2008 (Diabetes Mellitus, Experimental) : However, Ang-1 gene transfer did not modify the decrease in VEGF mRNA and protein expression in diabetic mice ; in contrast, Ang-1 increased eNOS expression and augmented nitrate wound content and VEGFR-2 immunostaining and protein expression
Chen et al., Arterioscler Thromb Vasc Biol 2008 (Diabetes Mellitus, Type 2...) : These alterations led to a significant impairment of Ang-1 induced Akt and eNOS phosphorylation, along with a remarkable impairment of Ang-1 induced endothelial cell migration and endothelial cell spheroid sprouting
Oubaha et al., Blood 2009 : In contrast to VEGF stimulation, Ang-1 causes a marked protein kinase C ( PKC ) -dependent increase in phosphorylation of eNOS on the inhibitory Thr ( 497 )
Chen et al., Exp Diabetes Res 2012 (Diabetes Mellitus, Type 2) : Treatment with PTP inhibitors restored Ang-1 induced Akt/eNOS phosphorylation and angiogenesis