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HIF1A — MAPK6
Text-mined interactions from Literome
Liu et al., J Biol Chem 2002
(Anoxia...) :
Finally, PGE ( 2 ) effects on
HIF-1alpha were specifically
inhibited by PD98059 ( a
MAPK inhibitor )
Sang et al., J Biol Chem 2003
(Anoxia...) :
We show that
MAPK is
required for the transactivation activity of
HIF-1 alpha
Gao et al., Toxicol Appl Pharmacol 2004
(Ovarian Neoplasms) :
To explore the mechanism of 4-OHE2 induced HIF-1alpha and VEGF-A expression, we studied whether phosphatidylinositol 3-kinase (PI3K) or mitogen activated protein kinase (
MAPK ) signaling pathways are
involved in 4-OHE2 induced
HIF-1alpha and VEGF-A expression
Murata et al., J Orthop Res 2006
(Anoxia...) :
Both hypoxia and IL-1 induced
HIF-1alpha were
attenuated by p38
MAPK and JNK inhibitors
Carnesecchi et al., Exp Cell Res 2006
:
We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic
activation of p42/44
MAPK and the induction of both Sp1 and
HIF-1alpha
Rezvani et al., J Biol Chem 2007
(Cell Transformation, Neoplastic) :
Indeed, activation of p38
MAPK and JNK1 mediated by mitochondrial ROS were
required for
HIF-1alpha phosphorylation and accumulation after UVB irradiation
Zhang et al., Free Radic Biol Med 2007
:
Activation of p38 MAPK and
HIF-1alpha accumulation were
attenuated by N-acetyl-L-cysteine ( antioxidant ), catalase ( hydrogen peroxide scavenger ), or a selective p38
MAPK inhibitor ( SB203580 )
Triantafyllou et al., Free Radic Biol Med 2008
(MAP Kinase Signaling System) :
Localization of HIF-1alpha by immuno- and direct fluorescence microscopy and in vitro phosphorylation assays suggest that flavonoids inhibit HIF-1 activity by impairing the
MAPK dependent phosphorylation of
HIF-1alpha , thereby decreasing its nuclear accumulation
Gelse et al., Osteoarthritis Cartilage 2008
(Cartilage Diseases) :
The functional
role of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) and
mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinase ( ERK ) signaling on BMP-2/IGF-1 induced
HIF-1alpha expression was assessed in vitro by employing specific inhibitors
Lin et al., Cell Physiol Biochem 2008
(Brain Ischemia...) :
However, BAPTA-AM ( an intracellular calcium chelator ), SB 203580 ( an inhibitor of p38 ) and
HIF-1alpha antisense significantly
inhibited the [ Ca ( 2+ ) ] ( i ), p38
MAPK phosphorylation and HIF-1alpha expression respectively ... Our results also showed that p38
MAPK phosphorylation was reduced by BAPTA-AM, and
HIF-1alpha expression was
inhibited by SB203580 and BAPTA-AM, suggesting that calcium, p38 MAPK and HIF-1alpha are in the same signal transduction pathways during LOGD
Mori et al., Mol Cancer Res 2009
(Pancreatic Neoplasms) :
In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by
KRAS/Raf/MAPK/Erk signaling, but
involves the IL-1beta/IL-1R system, p38, and the transcription factor
HIF-1alpha
Kuo et al., Biochem Biophys Res Commun 2009
(Breast Neoplasms) :
Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase (
MAPK ) signaling pathways are
involved in TNFalpha mediated
HIF-1alpha accumulation and activation under normoxic conditions
Sumbayev et al., Eur J Immunol 2009
:
ERK and p38
MAPK , but not reactive oxygen species ( ROS ), ASK1 or PI 3-kinase, were
critical for IgE mediated accumulation of
HIF-1alpha , although the latter crucially affected degranulation
Shin et al., Toxicol In Vitro 2010
:
Moreover, treatment with SP600125 or SB203580, but not PD98059, had partial inhibitory effects on the stability of HIF-1alpha protein induced by manganese, suggesting that p38
MAPK and JNK-1/2 also
contribute to the Mn-mediated
HIF-1alpha protein stability
Brant et al., Am J Respir Cell Mol Biol 2013
(Inflammation) :
The Ni-induced
HIF1A DNA binding was enhanced by PGE2 and
mediated , in part, by activation of p38
MAPK