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MAPK8 — SOS1
Pathways - manually collected, often from reviews:
-
WikiPathways Insulin Signaling:
RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10
→
MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14
(activation)
Text-mined interactions from Literome
Weng et al., Hum Mol Genet 2001
(Breast Neoplasms) :
PTEN
inhibits insulin stimulated
MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and
IRS-1/Grb-2/Sos complex formation in a breast cancer model
Shindo et al., J Gastroenterol 2006
(Wounds and Injuries) :
( 1 )
SOS activated IkappaB-alpha, but it did not
activate ERK1/2
MAPK
Tartaglia et al., Molecular syndromology 2010
:
SHP2 ( encoded by PTPN11 ),
SOS1 , BRAF, RAF1 and MEK1 positively
contribute to
RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations ... SHP2 ( encoded by PTPN11 ),
SOS1 , BRAF, RAF1 and MEK1 positively
contribute to
RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Corbalan-Garcia et al., Mol Cell Biol 1996
:
Previous studies have demonstrated that growth factor induced
Sos phosphorylation occurs at the C-terminal region of the protein and is
mediated , in part, by
mitogen activated protein ( MAP ) kinase
Lopez-Ilasaca et al., Science 1997
:
The tyrosine kinase class of receptors
induces mitogen activated protein kinase ( MAPK ) activation through the sequential interaction of the signaling proteins Grb2,
Sos , Ras, Raf, and MEK
Nimnual et al., Science 1998
:
Ras mediated activation of
DH-PH-Sos did not
require activation of
mitogen activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase