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EGR1 — PLD5

Text-mined interactions from Literome

Kim et al., Cancer Res 2006 : Etoposide induced activation of Akt was potentiated by overexpression of PLD and PLD stimulated suppression of Egr-1 was blocked by inhibition of phosphatidylinositol 3-kinase/Akt survival pathway at the both transcriptional and posttranscriptional levels
Ahn et al., FEBS Lett 2007 (Glioma) : Overexpression of catalytically inactive PLD , treatment with PA, and prevention of PA dephosphorylation by 1-propranolol significantly suppressed PMA induced Egr-1 expression ... PLD induced suppression of Egr-1 was reversed by inhibition of phosphatidylinositol 3-kinase (PI3K) ... Taken together, these results suggest that elevated expression and activity of PLD attenuate PMA induced Egr-1 expression via PI3K pathway