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HSPG2 — IL4

Text-mined interactions from Literome

Hashimoto-Uoshima et al., J Periodontal Res 2002 (Gingivitis) : IL-4 stimulated synthesis of versican and perlecan-type more potently than biglycan and decorin-type
Ho et al., J Exp Med 1994 : Experiments were performed using [ 14C-methyl ] choline labeled U937 cells and monocytes to determine whether IL-4R activated phospholipase C (PLC) , PLD, or PLA2 to use membrane phosphatidylcholine ( PC ) to form DAG ... The finding that the peak reduction of PC was equivalent to peak production of pchol suggested that IL-4R signaling involved the activation of a PC-specific PLC ... In summary, IL-4R signaling in monocytes and U937 cells involves PLC and not PLD, PLA2, or SMase, and it uses PC and not PIP2 to form DAG
Tschaikowsky et al., J Pharmacol Exp Ther 1998 (Shock, Septic) : Inhibition of PC-PLC by the specific inhibitor tricyclodecan-9-yl-xanthogenate ( D609 ) before LPS reduced the release of interleukin-1 beta, interleukin-6 and nitric oxide ( NO ) in vivo