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IL1B — TGFB1

Pathways - manually collected, often from reviews:

• WikiPathways Lung fibrosis: IL1B → TGFB1 (unknown)

Text-mined interactions from Literome

Kang et al., Perit Dial Int 1999 (Peritonitis) : Stimulation with IL-1beta ( 1 ng/mL ) or TNFalpha ( 1 ng/mL ) resulted in a significant increase in TGFbeta1 mRNA expression after 48 hours : 2.7 and 2.1 times the control level, respectively ... However, TNFalpha induced increase in TGFbeta1 mRNA expression was not translated intoTGFbeta1 protein secretion, while IL-1beta stimulation induced a significant increase in TGFbeta1 protein secretion as well as TGFbeta1 mRNA expression
Stefani et al., Pancreas 1999 (Liver Neoplasms...) : Both IL-1alpha and IL-1beta reduced CD44 membrane expression of MIA PaCa 2, while TGF-beta1 increased the percentage of CD44 positive CAPAN-1 cells
Ledeboer et al., Glia 2000 : LPS induced levels of IL-1beta were suppressed by IL-10, but not by IL-4 and TGF-beta1/beta2
Park et al., Nephrol Dial Transplant 2000 : TGF-beta(1) ( 10 ng/ml ) inhibited both IL-1beta- ( 5 ng/ml ) and TNF-alpha- ( 10 ng/ml ) induced expression of VCAM-1 ( MFI : IL-1beta=90. 8+/- 17.6, IL-1beta+TGF-beta(1)=37.8+/-14.9, TNF-alpha=113.6+/- 12.4, TNF-alpha+TGF-beta(1)=64.3+/-13.8, mean+/-SD, n=3, P < 0.05 )
Worapamorn et al., J Periodontal Res 2002 : The effect of IL-1 beta on syndecan-1 mRNA synthesis was partially reversed after adding PDGF-BB and TGF-beta 1 , separately or in combination, in the presence of IL-1 beta
Basu et al., Glia 2002 (Brain Injuries...) : TGFbeta1 blocked activation by IL-1beta when given prior to, or simultaneously with, IL-1beta
Vesey et al., J Lab Clin Med 2002 : We found that IL-1beta significantly stimulated DNA synthesis ( 356.7 % +/- 39 % of control, P < .003 ), fibronectin secretion ( 261.8 +/- 11 % of control, P < .005 ), collagen type 1 production, ( release of procollagen type 1 C-terminal-peptide, 152.4 % +/- 26 % of control, P < .005 ), transforming growth factor-beta ( TGF-beta ) secretion ( 211 % +/- 37 % of control, P < .01 ), and nitric oxide ( NO ) production ( 342.8 % +/- 69 % of control, P < .002 )
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003 : IL-1beta and TGF-beta1 induced an activation of ERK p42/44 and p38 MAP kinases, and the MAP kinase inhibitors ( SB-202190, PD-98059, and U-0216 ) significantly reduced the IL-1beta- and TGF-beta1 induced IL-11 secretion
Andriamanalijaona et al., Arthritis Rheum 2003 : Mediation of interleukin-1beta induced transforming growth factor beta1 expression by activator protein 4 transcription factor in primary cultures of bovine articular chondrocytes : possible cooperation with activator protein 1 ... IL-1beta induces an increase of TGFbeta1 in articular chondrocytes through activation of AP-4 and AP-1 binding to the TGFbeta1 gene promoter
Shikhman et al., Am J Physiol Endocrinol Metab 2004 : Although both IL-1beta and TGF-beta1 enhance glucose transport in chondrocytes to a similar magnitude, IL-1beta induces significantly higher levels of lactate
Wondergem et al., Atherosclerosis 2004 : Compared to cultures exposed to injury alone, radiation induced significant ( P < 0.05 ) increases in mRNA levels of IL-8 ( 1.35 +/- 0.10-fold increase at 4h ), FGF-2 ( 1.62 +/- 0.10-fold at 4h ; 1.76 +/- 0.33-fold at 24h ) and IL-1beta ( 2.76 +/- 0.40-fold at 24h ), whereas mRNA levels of TGF-beta1 , PDGF-A and PDGF-B increased about 1.2-fold
Jarai et al., Eur J Pharmacol 2004 : Interleukin-1beta induces a predominantly pro-inflammatory profile while TGFbeta1 can be linked to proliferative and matrix changes
Bullen et al., Am J Physiol Endocrinol Metab 2004 (Body Weight...) : Real-time PCR analysis confirmed that expression of the hypothalamic IL-1 pathway ( IL-1beta , IL-1 type 1 and 2 receptors, and PPM1b/PP2C-beta, a molecule that has been implicated in the inhibition of transforming growth factor-beta activated kinase-1 mediated IL-1 action ) is altered after 2 days, but not 1 wk, of high-fat feeding
Sanchez et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : IL-6, but not OSM, reversed IL-1beta induced TGF-beta1 inhibition
Martin et al., Arthritis Rheum 2004 (Anoxia) : Stimulation of TGFbeta1 expression by IL-1beta was observed only in normal atmospheric conditions
Martin et al., Osteoarthritis Cartilage 2005 : However, although H ( 2 ) O ( 2 ) and IL-1beta were capable of increasing TGF-beta1 expression separately, subsequent incubation with both factors led to a partial or total abolition of TGF-beta1 up-regulation
Shvedova et al., Am J Physiol Lung Cell Mol Physiol 2005 (Granuloma, Foreign-Body...) : In vitro exposure of murine RAW 264.7 macrophages to SWCNT triggered TGF-beta1 production similarly to zymosan but generated less TNF-alpha and IL-1beta
Serlin et al., J Cell Biochem 2006 : Our results demonstrate a potent and dramatic increase in osteopontin expression induced by interleukin-1beta (IL-1beta) , whereas tumor necrosis factor-alpha, transforming growth factor-beta , and angiotensin II had minimal effect
Fain et al., Metabolism 2005 (Obesity, Morbid) : The question of whether tumor necrosis factor alpha (TNF-alpha) and/or interleukin 1 beta (IL-1 beta) regulate the release of TGF-beta1 was investigated by incubation of adipose tissue explants with a soluble human TNF-alpha receptor ( etanercept ) and a neutralizing antihuman IL-1 beta antibody ... The release of TGF-beta1 over 48 hours by adipose tissue explants was significantly enhanced in the presence of both the inhibitor of TNF-alpha and of IL-1 beta
Lee et al., J Immunol 2006 : NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta induced TGF-beta1 gene transcription ... IL-1beta induced TGF-beta1 protein secretion and mRNA expression were prevented by actinomycin D and were attenuated by the inhibitor of kappaB kinase 2 inhibitor AS602868 and the JNK inhibitor SP600125, suggesting a degree of transcriptional regulation mediated by the NF-kappaB and AP-1 pathways ... The specific NF-kappaB and AP-1 binding sites in the TGF-beta1 promoter were confirmed by an ELISA based binding assay, and evidence for histone hyperacetylation in TGF-beta1 induction was supported by the observation that the histone deacetylase inhibitor trichostatin A enhanced basal and IL-1beta induced TGF-beta1 mRNA expression
Aoki et al., Am J Physiol Cell Physiol 2006 : Inhibition of TGF-beta(1) activity secreted from PSCs by TGF-beta(1) neutralizing antibody attenuated IL-1beta secretion from PSCs. Exogenous TGF-beta(1) increased IL-1beta expression and secretion by PSCs in a dose dependent manner ... Adenovirus mediated expression of dominant negative ( dn ) Smad2/3 expression reduced both basal and TGF-beta(1) stimulated IL-1beta expression and secretion by PSCs. Coexpression of Smad3 with dnSmad2/3 restored IL-1beta expression and secretion by PSCs, which were attenuated by dnSmad2/3 expression ... Furthermore, inhibition of IL-1beta activity secreted from PSCs by IL-1beta neutralizing antibody attenuated TGF-beta(1) secretion from PSCs. Exogenous IL-1beta enhanced TGF-beta(1) expression and secretion by PSCs. IL-1beta activated ERK, and PD-98059, a MEK1 inhibitor, blocked IL-1beta enhancement of TGF-beta(1) expression and secretion by PSCs
Li et al., J Biol Chem 2006 : Surprisingly, this brief exposure to FC-AMs triggered a modest proinflammatory response in the phagocytes : tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta were induced , whereas the levels of transforming growth factor-beta and IL-10 were not increased
Fang et al., Nephrol Dial Transplant 2006 (Fibrosis) : Diltiazem suppresses collagen synthesis and IL-1beta induced TGF-beta1 production on human peritoneal mesothelial cells ... The objectives of this study were to examine the effects of diltiazem on collagen- and IL-1beta induced TGF-beta1 production on human PMCs and the signalling pathway of diltiazem in this induction ... Diltiazem suppressed collagen synthesis of human PMCs and inhibited IL-1beta induced TGF-beta1 production on human PMCs
Andriamanalijaona et al., J Periodontol 2006 (Hemolysis) : Effect of interleukin-1beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture : modulation by avocado and soybean unsaponifiables ... In this study, we investigated the in vitro effect of avocado and soya unsaponifiables ( ASU ) on the expression of TGF-beta1 , TGF-beta2, and bone morphogenetic protein-2 (BMP-2) by human periodontal ligament (HPL) and human alveolar bone ( HAB ) cells in the presence of IL-1beta
Aoki et al., Am J Physiol Cell Physiol 2007 : IL-6 as well as IL-1beta enhanced TGF-beta1 secretion from PSCs
Nagineni et al., J Cell Physiol 2007 : RT-PCR analyses showed that TNF-alpha and IL-1beta increased the mRNA levels of both TGF-beta1 and TGF-beta2 ... IFN-gamma enhanced constitutively expressed, as well as, TNF-alpha-and IL-1beta induced TGF-beta1 mRNA levels but decreased TGF-beta2 mRNA
Suzuki et al., J Cell Physiol 1991 (Blast Crisis...) : Third, leukemic cells of the two patients studied were revealed to secrete IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) constitutively ; the production by leukemic cells of IL-1 beta and TNF-alpha was significantly promoted by TGF-beta 1
Tsuji et al., Spine (Phila Pa 1976) 2007 : Expression of TIMP-3 mRNA in NP was upregulated by TGF-beta1 but was not affected by IL-1beta
Baugé et al., Arthritis Rheum 2007 : TGFbetaRII overexpression abolished the loss of TGFbeta1 responsiveness induced by IL-1beta
Ganter et al., Circ Res 2008 (Pulmonary Edema...) : The results of in vitro studies indicated that IL-1beta caused the activation of transforming growth factor-beta via RhoA/alphavbeta6 integrin dependent mechanisms and the inhibition of the alphavbeta6 integrin and/or transforming growth factor-beta signaling completely blocked the IL-1beta mediated protein permeability across alveolar epithelial cell monolayers
Lee et al., Tissue Eng Part A 2008 : TGF-beta1 up-regulated the expression of SZP in cultured explants, but IL-1beta down-regulated it ... Real-time polymerase chain reaction analysis revealed that TGF-beta1 significantly up-regulated SZP expression and that IL-1beta down-regulated it
Chen et al., Zhong Xi Yi Jie He Xue Bao 2009 : Compared with the blank control group, IL-1beta might induce TEMT, which was showed in increasing expression of alpha-SMA, increasing secreting of FN and decreasing expression of E-cadherin, and at the same time the expressions of TGF-beta1 and ILK were enhanced ( P < 0.05 )
Ohtani et al., Immunology 2009 (Necrosis) : TGF-beta1 treatment, which augmented E-cadherin and down-regulated dendritic cell-specific ICAM3 grabbing non-integrin on MoDCs, significantly suppressed their CD86 expression and hapten induced expression of IL-1beta and TNF-alpha mRNA and protein
Luo et al., Nephrol Dial Transplant 2009 : Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling
Annunziato et al., Blood 2009 (Autoimmune Diseases) : While murine Th17 cells develop in response to IL-6, IL-1, and transforming growth factor ( TGF ) -beta , human Th17 cells originate from these CD161 ( + ) precursors in response to IL-1beta and IL-23, the need for TGF-beta being controversial
Doerner et al., Respir Res 2009 (Airway Remodeling...) : TGF-beta1 induced epithelial to mesenchymal transition ( EMT ) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids
Nemunaitis et al., Eur J Haematol 1991 : Neither interleukin-1 (IL-1)beta nor IL-6 had an observable effect on TGF beta 1 mRNA expression
Markovics et al., J Biol Chem 2011 : Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta activating integrin subunit beta8 through altering chromatin architecture
Kauma et al., Am J Obstet Gynecol 1990 : On the basis of these findings, we suggest that the increase in decidual interleukin-1 beta and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that transforming growth factor-beta production may regulate the local maternal immune response and prevent rejection of the fetus
Kuppner et al., Immunology 1995 : We investigated the effect of transforming growth factor-beta ( TGF-beta ) on interleukin-1 beta (IL-1 beta) induction of IL-6 and IL-8 mRNA levels and protein production by human RPE cells
Yue et al., Biochem Biophys Res Commun 1994 : Interleukin-1 beta (IL-1 beta) induces transforming growth factor-beta , ( TGF-beta 1 ) production by rat aortic smooth muscle cells ... In cultured rat aortic smooth muscle cells ( RASMCs ) IL-1 beta induced TGF-beta 1 mRNA expression, which was concentration ( 10 pM-10 nM ) - and time ( 2-48 h ) -dependent, and sensitive to cycloheximide ... Our data demonstrate for the first time that IL-1 beta is a potent inducer of TGF-beta 1 synthesis and release in vascular smooth muscle cells
Barnum et al., J Immunol 1994 (Inflammation) : In this report, we show that transforming growth factor-beta ( TGF-beta ) can significantly inhibit the capacity of IFN-gamma, IL-1 beta , and TNF-alpha to augment expression of the central component of complement C3 in the human astroglioma cell line D54-MG. Treatment of D54-MG cells with TGF-beta alone had no dose- or time dependent effect on basal C3 protein or mRNA levels
Offner et al., Am J Pathol 1996 : Stimulation of HPMCs with IL-1 beta increased steady-state levels of TGF-beta 1- and TGF-beta 2-specific mRNA
Fischer et al., Ann Oncol 1995 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, TGF beta 1 suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha but not of IL-1 alpha and IL-1 beta in whole blood cell cultures from healthy individuals
Skop et al., Biochimie 1996 : The following conclusions have been drawn as the result of the experiment : 1 ) TGF-beta 1 stimulates the synthesis of proteoglycans and collagen in endothelial cell culture, whereas IL-1 beta has the opposite action ; and 2 ) TGF-beta 1 reduces IL-1 beta action which hampers the synthesis of proteoglycans and collagen, provided that the culture 's preincubation with TGF-beta 1 precedes the incubation with IL-1 beta
Kang et al., Exp Dermatol 1996 : TGF beta 1 did not affect IL-1 beta mRNA levels but caused variable increases in IL-1 beta protein levels
Phillips et al., Kidney Int 1996 : Stimulation of TGF-beta 1 synthesis by IL-1 beta in D-glucose primed cells was inhibited by cycloheximide but not by actinomycin-D ... These results demonstrate that the interaction of D-glucose and IL-1 beta lead to secretion of TGF-beta 1 by HPTC
Hu et al., Glia 1995 : The anti-inflammatory cytokines IL-4 and IL-10 potently suppressed IL-1 beta plus IFN-gamma stimulated NO, while transforming growth factor-beta preferentially inhibited IL-1 beta plus TNF-alpha stimulated production of NO
Karres et al., Arch Surg 1996 : In contrast, neither IL-1 beta mRNA expression nor IL-1 beta protein synthesis were attenuated by TGF-beta 1
Wang et al., Clin Orthop Relat Res 1997 (Bone Neoplasms...) : Titanium, cobalt, and chromium at concentrations ranging from 0.01 to 100 ng/ml significantly enhanced the release of interleukin-1 beta and tumor necrosis factor-alpha by lipopolysaccharide stimulated human osteogenic sarcoma cells, whereas they did not alter the release of transforming growth factor-beta 1
Høgåsen et al., Scand J Clin Lab Invest 1998 : In contrast, transforming growth factor-beta ( TGF-beta, 10 ng/ml ), a cytokine which is abundant in bone matrix, suppressed median IL-1 beta release to 13 % of control value ( p < 0.01 )
Pawluczyk et al., Kidney Int 1998 (Cicatrix) : TGF-beta 1 : TNF-alpha and TGF-beta 1 : IL-1 beta induced additive increases in TIMP-1 ( tissue inhibitor of metalloproteinases-1 ) mRNA levels
Kim et al., Am J Obstet Gynecol 1998 : In the medium containing lipopolysaccharide plus transforming growth factor-beta2, transforming growth factor-beta2 also decreased the lipopolysaccharide induced prostaglandin E2 production significantly at the concentrations of 1 ng/mL and 10 ng/mL ( P < .05 ) but increased the lipopolysaccharide induced interleukin-1beta production significantly at the concentration of 1 ng/mL ( P < .05 )
Spyridonidis et al., Blood 1999 (Ascites...) : Expansion of clonogenic tumor cells was seen in the presence of SCF + IL-1beta + IL-3 + IL-6 + EPO, but was suppressed by TGF-beta1