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IL1B — PLAU

Text-mined interactions from Literome

Solomon et al., Invest Ophthalmol Vis Sci 2000 (Pterygium) : Both IL-1beta and TNF-alpha induced a significant decrease in uPA expression in PBF, whereas bFGF induced a slight increase in both HJF and PBF
Chung et al., J Clin Endocrinol Metab 2001 : Interleukin-1beta regulates urokinase plasminogen activator (u-PA) , u-PA receptor, soluble u-PA receptor, and plasminogen activator inhibitor-1 messenger ribonucleic acid expression in cultured human endometrial stromal cells
Kiguchi et al., Int J Cancer 2001 (Lung Neoplasms...) : We previously reported that both IL-1beta and LPS induce uPA in RC-K8 human lymphoma cells
Ogura et al., IUBMB Life 2001 : IL-1beta increases uPA and uPA receptor expression in human gingival fibroblasts ... In addition, IL-1beta increased the protein and mRNA levels of both uPA and uPAR in gingival fibroblasts ... These findings suggest that the enhancement of uPA and uPAR levels by IL-1beta may play an important role in the progression of periodontal diseases through pericellular proteolysis, and subsequent cellular behavior
Iwamoto et al., Dig Dis Sci 2003 (Stomach Ulcer) : To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer, the effects of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha on the expression of uPA and uPAR, which were suggested to be associated with tissue remodeling, in gastric fibroblasts were investigated
Kamio et al., Biomed Res 2007 : The IL-1beta stimulated uPA mRNA expression and PA activities in the cell lysate and medium were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrolidinedithiocarbamate, and were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate
Louwrens et al., Eur J Vasc Endovasc Surg 1995 (Aortic Aneurysm, Abdominal) : IL-1 beta suppressed production of uPA and tPA in both types of SMCs
Niiya et al., Thromb Haemost 1995 (Lymphoma, B-Cell...) : Recombinant IL-1 alpha, recombinant IL-1 beta and LPS but not recombinant IL-6, recombinant TNF alpha and TGF beta dose-dependently increased uPA accumulation in the conditioned medium ... Both IL-1 alpha and IL- 1 beta rapidly activated uPA gene transcription, but not increased stability of uPA mRNA ... These results suggest that both IL-1 alpha and IL-1 beta cause a rapid activation of uPA gene transcription in which de novo protein synthesis is not required and that LPS induces uPA gene expression independently of the IL-1 pathway