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FGF2 — IL1B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FGF2 → IL1B (increases)
  Evidence: Moreover, osmotic shock and shear stress induce the release of FGF2 from endothelial cells [209,210]. FGF2 production and release from endothelial cells are also triggered by IFN-a plus IL-2 [211], IL-1b [212], and nitric oxide (NO) [213].

Text-mined interactions from Literome

Solomon et al., Invest Ophthalmol Vis Sci 2000 (Pterygium) : Both IL-1beta and TNF-alpha induced a significant decrease in uPA expression in PBF, whereas bFGF induced a slight increase in both HJF and PBF
Albrecht et al., Exp Neurol 2002 : RT-PCR analysis demonstrated that CNTF increased levels of FGF-2 and nerve growth factor (NGF) mRNA and that IL-1beta increased NGF and hepatocyte growth factor mRNA levels ... Furthermore, both CNTF and IL-1beta stimulated the release of FGF-2 from cultured spinal cord astrocytes
Lee et al., J Biol Chem 2004 (Inflammation) : IL-1 beta greatly increased the levels of FGF-2 mRNA in a time- and dose dependent manner ; IL-1 beta stimulated expression of all isoforms of FGF-2 ... IL-1 beta initially induced nuclear accumulation of FGF-2 and facilitated translocation of FGF-2 to plasma membrane and extracellular matrix
Hayashi et al., J Obstet Gynaecol Res 2006 : The production of VEGF, bFGF and TGF-beta respectively was enhanced by both IL-1beta and TNF-alpha
Hirose et al., Cell Transplant 2008 (Ischemia) : Expression of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor ( VEGF ) of mRNA in P-MNCs was apparently enhanced by hypoxic stimulation, and the production of VEGF protein was also augmented by hypoxia and IL-1beta
Sandell et al., Osteoarthritis Cartilage 2008 (Arthritis) : In the presence of IL-1beta , FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1, CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6, and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Gay et al., Proc Natl Acad Sci U S A 1991 : We report here that HBGF-2 gene expression in human saphenous vein smooth muscle cells is induced by interleukin (IL)-1 alpha and IL-1 beta , inflammatory cytokines produced by many cell types in response to a variety of signals
Herseth et al., Particle and fibre toxicology 2008 : However, exogenous IL-1beta reduced the FGF-2 levels, strongly elevated the FGF-2 binding protein PTX3, and prevented the reduction in the number of pneumocytes induced by silica
Song et al., Invest Ophthalmol Vis Sci 2010 (Corneal Opacity) : Induction of FGF-2 synthesis by IL-1beta in aqueous humor through P13-kinase and p38 in rabbit corneal endothelium
Yudoh et al., Int J Rheum Dis 2009 (MAP Kinase Signaling System...) : Chondrocytes were stimulated with or without IL-1beta ( 10 ng/mL ) in the presence or absence of vascular endothelial growth factor, basic fibroblast growth factor or hepatocyte growth factor ( 20 ng/mL )
Rivera et al., Brain Res Mol Brain Res 1994 : Interleukin-1 beta increases basic fibroblast growth factor mRNA expression in adult rat brain and organotypic hippocampal cultures ... In situ hybridization was used to study the effect of IL-1 beta on acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) mRNA expression in rat brain ... To determine if IL-1 beta effects were independent of activation of the hypothalamo-pituitary-adrenal axis, and to compare the cellular localization of increases in bFGF mRNA expression induced by IL-1 beta and bFGF, the regulation of bFGF expression was also studied in organotypic hippocampal slice cultures ... These findings suggest that IL-1 beta induction of bFGF contributes to the coactivation of these substances following various forms of insult to the CNS and initiates a cascade of trophic interactions that regulates processes of glial proliferation, neurotrophic factor expression, and neuroprotection
Berardi et al., Blood 1995 : To address the direct effects of FGF, we investigated whether FGF induced production of interleukin-1 beta (IL-1 beta) , tumor necrosis factor alpha, IL-6, granulocyte colony stimulating factor, or granulocyte-macrophage colony stimulating factor by two types of accessory cells, bone marrow ( BM ) fibroblasts and macrophages
Ito et al., Cardiovasc Res 1996 (Coronary Artery Disease...) : These results suggest that the vascular effects of IL-1 beta may also be mediated by FGF-2 in our swine model and that chronic treatment with FGF-2 also causes coronary arteriosclerotic changes and vasospastic responses in vivo ... This study was designed to examine, first, whether the effects of IL-1 beta are also partially mediated by fibroblast growth factor-2 (FGF-2) , which is another important growth factor in atherosclerotic lesions, and, secondly, whether chronic treatment with FGF-2 per se also induces histological and functional changes in porcine coronary arteries in vivo
Fischer et al., Am J Physiol 1997 : Interleukin-1beta (IL-1beta) , which like ANG II and ET-1 is known to activate mitogen activated protein kinases in both ARVM and CMEC, increased bFGF mRNA levels only in cardiac myocytes
Kunz et al., J Clin Invest 1997 : Platelet derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP induced nitric oxide synthase expression in rat renal mesangial cells
Walker et al., Biochim Biophys Acta 1998 : Platelet derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells