Gene interactions and pathways from curated databases and text-mining

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ADM — IL1B

Text-mined interactions from Literome

Udono et al., Invest Ophthalmol Vis Sci 2000 : Regulation of the ADM expression by basic fibroblast growth factor, interferon (IFN)-gamma, tumor necrosis factor-alpha, interleukin (IL)1beta , or all-trans-retinoic acid was studied ... IFN-gamma and IL-1beta induced ADM expression in ARPE-19 cells
Görbig et al., J Hepatol 2001 (Calcium Signaling) : ADM secretion was markedly enhanced by tumour necrosis factor-alpha and interleukin-1beta
Hofbauer et al., Hypertension 2002 : For this purpose, we characterized the effects of inflammatory cytokines, tumor necrosis factor-alpha ( 100 microg/L ), interleukin-1beta ( 20 microg/L ), and interferon-gamma ( 0.5 U/L ) on ADM gene expression in rat aortic vascular smooth muscle cells ( AVSMCs )
von der Hardt et al., Eur J Pharmacol 2002 : The effect of aerosolized adrenomedullin on interleukin-1 beta and transforming growth factor (TGF)-beta1 mRNA and protein expression was studied in surfactant depleted piglets, receiving aerosolized adrenomedullin ( adrenomedullin, n=6 ), aerosolized adrenomedullin plus i.v. N ( G ) -nitro-L-arginine-methylester ( adrenomedullin+L-NAME, n=5 ), or aerosolized saline solution ( control, n=6 )
Wong et al., Endocrinology 2005 (Inflammation) : ADM increased initial secretion of MIF and IL-1beta from both nonstimulated and LPS stimulated cells, and it also increased basal and LPS induced IL-6 secretion of the cells by 2- to 15-fold
Linscheid et al., Endocrinology 2005 (Sepsis) : Interferon-gamma coadministration inhibited IL-1beta mediated ProCT and CGRP secretion by 78 and 34 %, respectively but augmented IL-1beta mediated ADM secretion by 50 %
Nishikimi et al., Cardiovasc Res 2005 : ( 2 ) IL-1beta significantly increased gene expression of adrenomedullin and its receptor components ( adrenomedullin : +46 %, CRLR : +460 %, RAMP2 : +32 %, RAMP3 : +350 %, all P < 0.01 )
Chini et al., Kidney Int 1997 : MC grown in primary culture synthesized ADM , and the synthesis was stimulated by TNF alpha and IL-1 beta but not by PDGF and EGF