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ACE — TNF
Text-mined interactions from Literome
Kawamura et al., Hypertens Res 2002
(Hypertension) :
These data indicate that the local TNF-alpha expression is tissue-specific, and that
upregulation of
TNF-alpha in EPI by exercise training and/or
ACE inhibition may have contributed to the reduction in fat cell volume via the induction of apoptosis and/or the regulation of metabolic homeostasis
Dalbeth et al., Rheumatology (Oxford) 2005
(Arthritis, Experimental) :
In parallel human in vitro experiments,
ACE inhibition
suppressed LPS stimulated production of
TNF-alpha by monocytes
Ohgami et al., Invest Ophthalmol Vis Sci 2005
(Disease Models, Animal...) :
The results suggest that
ACE has a dose dependent anti-ocular inflammatory effect that is due to the direct blocking of the expression of the iNOS and COX-2 enzymes and
leads to the suppression of the production of NO, PGE2, and
TNF-alpha
Spencer et al., Dig Dis Sci 2007
(Colitis) :
In addition, pharmacologic
ACE inhibition (ACE-I) both prevents apoptosis and
reduces TNF-alpha expression in vitro
Hoch et al., Am J Physiol Regul Integr Comp Physiol 2009
:
Inhibition of T-cell
ACE reduced
TNF-alpha production, indicating endogenously produced ANG II has a regulatory role in this process
Koumbadinga et al., Peptides 2010
:
Tumor necrosis factor (TNF)-alpha repressed the expression of
ACE in HUVECs while phorbol 12-myristate 13-acetate ( PMA ) upregulated it in 24h ( approximately 12-fold dynamic range by [ ( 3 ) H ] enalaprilat binding, corroborated by ACE immunoblotting )
Liao et al., Am J Chin Med 2013
(Edema) :
EA-ACE affects the serum NO,
TNF-a , and IL-1ß levels at the 5th hr after Carr injection
Fukuzawa et al., Immunopharmacology 1997
:
Angiotensin converting enzyme inhibitors
suppress production of
tumor necrosis factor-alpha in vitro and in vivo ... Therefore, in this study, we examined
effect of
ACE inhibitors on
TNF-alpha production both in vitro and in vivo by using human blood mononuclear cells and mice, respectively