Gene interactions and pathways from curated databases and text-mining

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ACE — TNF

Text-mined interactions from Literome

Kawamura et al., Hypertens Res 2002 (Hypertension) : These data indicate that the local TNF-alpha expression is tissue-specific, and that upregulation of TNF-alpha in EPI by exercise training and/or ACE inhibition may have contributed to the reduction in fat cell volume via the induction of apoptosis and/or the regulation of metabolic homeostasis
Dalbeth et al., Rheumatology (Oxford) 2005 (Arthritis, Experimental) : In parallel human in vitro experiments, ACE inhibition suppressed LPS stimulated production of TNF-alpha by monocytes
Ohgami et al., Invest Ophthalmol Vis Sci 2005 (Disease Models, Animal...) : The results suggest that ACE has a dose dependent anti-ocular inflammatory effect that is due to the direct blocking of the expression of the iNOS and COX-2 enzymes and leads to the suppression of the production of NO, PGE2, and TNF-alpha
Spencer et al., Dig Dis Sci 2007 (Colitis) : In addition, pharmacologic ACE inhibition (ACE-I) both prevents apoptosis and reduces TNF-alpha expression in vitro
Hoch et al., Am J Physiol Regul Integr Comp Physiol 2009 : Inhibition of T-cell ACE reduced TNF-alpha production, indicating endogenously produced ANG II has a regulatory role in this process
Koumbadinga et al., Peptides 2010 : Tumor necrosis factor (TNF)-alpha repressed the expression of ACE in HUVECs while phorbol 12-myristate 13-acetate ( PMA ) upregulated it in 24h ( approximately 12-fold dynamic range by [ ( 3 ) H ] enalaprilat binding, corroborated by ACE immunoblotting )
Liao et al., Am J Chin Med 2013 (Edema) : EA-ACE affects the serum NO, TNF-a , and IL-1ß levels at the 5th hr after Carr injection
Fukuzawa et al., Immunopharmacology 1997 : Angiotensin converting enzyme inhibitors suppress production of tumor necrosis factor-alpha in vitro and in vivo ... Therefore, in this study, we examined effect of ACE inhibitors on TNF-alpha production both in vitro and in vivo by using human blood mononuclear cells and mice, respectively