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IGF1 — VIP
Text-mined interactions from Literome
Servoss et al., Endocrinology 2001
:
Both
VIP- and activity dependent neurotrophic factor stimulated growth were
blocked by
anti-IGF-I , whereas anti-activity dependent neurotrophic factor-14 had no detectable effect on IGF-I induced growth
Fernández et al., Neuroendocrinology 2003
:
In previous studies we demonstrated that
insulin-like growth factor I (IGF-I) induces pituitary
vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I induced prolactin (PRL) release is mediated by VIP ... These results indicate that both
IGF-I and VIP stimulate lactotrope proliferation, and that IGF-I induced lactotrope proliferation is partially
mediated by
VIP produced locally
Saitoh et al., Cell Tissue Res 2010
:
In addition, no vasoactive intestinal peptide (VIP)-immunoreactive cells were found in KO mice, therefore
IGF-I is
essential for
VIP expression
Lara et al., Endocrinology 1994
:
The
effects of recombinant human
insulin-like growth factor I (IGF-I) on both
vasoactive intestinal peptide (VIP) and PRL production and gene expression were studied using rat anterior pituitary cell cultures grown in serum-free defined medium ... In conclusion, these results indicate that
IGF-I induces
VIP gene expression, and its secretion and also increases PRL secretion ... The effect of
IGF-I on PRL release is specifically
mediated by
VIP through a paracrine or autocrine mechanism