◀ Back to NFKB1
CSN3 — NFKB1
Text-mined interactions from Literome
Hong et al., FEBS Lett 2001
:
Overexpression of
CSN3 inhibits
NF-kappaB activation triggered by tumor necrosis factor (TNF), but not interleukin-1 (IL-1) ... Moreover, overexpression of
CSN3 also
inhibits NF-kappaB activation triggered by proteins involved in TNF signaling, including TNF-R1, TRAF2, RIP, and NIK, but not by TRAF6, a protein involved in IL-1 signaling
Kweon et al., Biochem Biophys Res Commun 2006
(Inflammation...) :
Moreover,
casein kinase 2 ( CK2 ) is
involved in synergistic induction of
NF-kappaB via a mechanism dependent on phosphorylation of p65 at both Ser536 and Ser276 sites
Schweitzer et al., EMBO J 2007
:
CSN controls
NF-kappaB by deubiquitinylation of IkappaBalpha ... For the first time, we show here an inducible interaction of the
CSN with IkappaBalpha and that the CSN
controls IkappaBalpha and
NF-kappaB activity ... Strikingly, disruption of the
CSN by a small interfering RNA mediated knockdown of single CSN subunits
results in a reduced re-accumulation of IkappaBalpha and prolonged nuclear translocation of
NF-kappaB in TNFalpha stimulated cells
Willems et al., Molecular cancer 2010
(Liposarcoma, Myxoid) :
Kinome profiling of myxoid liposarcoma reveals
NF-kappaB-pathway kinase activity and
casein kinase II
inhibition as a potential treatment option