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MMP13 — POLDIP2
Text-mined interactions from Literome
Boström et al., Int J Cancer 2000
(Carcinoma, Transitional Cell...) :
Retinoids and a selective
p38 inhibitor, SB203580, potently
inhibited MMP-13 mRNA expression
Zeliadt et al., Toxicol Appl Pharmacol 2003
:
Diverse stimuli
require JNK and
p38 to increase
MMP-13 gene expression, however ... Surprisingly, palytoxin does not
require JNK and
p38 to increase
MMP-13 gene expression
Fan et al., Rheumatol Int 2006
:
Our data suggest that ERK and NFkB pathways are particularly important for IL-1beta regulating collagen type II and MMP-1 and -13 expression and that
p38 , but not JNK is additionally
involved in
MMP-1 and -13 induction
Pei et al., Osteoarthritis Cartilage 2006
(Chondrosarcoma) :
The possible involvement of the Runx2 pathway in mediating
p38 effects on
MMP-13 expression was analyzed using promoter-reporter assays, ELISA and immunoprecipitation analyses
Junttila et al., Oncogene 2007
(Carcinoma, Squamous Cell...) :
Inhibition of endogenous
p38alpha or p38delta activity by adenoviral delivery of corresponding dominant negative p38 isoforms potently
reduced MMP-13 and MMP-1 expressions, and suppressed the invasion of HNSCC cells through collagen
Long et al., Osteoarthritis Cartilage 2010
(Inflammation...) :
Inhibition of both
p38alpha and p38gamma with BIRB796
resulted in less inhibition of
MMP-13 production in response to IL-1beta or FN-f than did inhibition of only p38alpha with SB203580
Meephansan et al., Clin Exp Dermatol 2012
(Carcinoma, Squamous Cell...) :
Induction of MMP-9 by TNF-a was suppressed by an extracellular signal regulated kinase ( ERK ) inhibitor but not by a p38 inhibitor, whereas induction of
MMP-13 was
inhibited by a
p38 inhibitor but not by an ERK inhibitor