◀ Back to CTNNB1
CDH2 — CTNNB1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database N-cadherin signaling events:
LRP5 (LRP5)
→
N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1)
(modification, collaborate)
Haÿ et al., Mol Cell Biol 2009
Evidence: physical interaction, other species
-
NCI Pathway Database N-cadherin signaling events:
LRP5 (LRP5)
→
N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1)
(modification, collaborate)
Haÿ et al., Mol Cell Biol 2009
Evidence: physical interaction, other species
-
NCI Pathway Database N-cadherin signaling events:
Axin1 (AXIN1)
→
N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1)
(modification, collaborate)
Haÿ et al., Mol Cell Biol 2009
Evidence: physical interaction, other species
-
NCI Pathway Database N-cadherin signaling events:
Axin1 (AXIN1)
→
N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1)
(modification, collaborate)
Haÿ et al., Mol Cell Biol 2009
Evidence: physical interaction, other species
-
NCI Pathway Database N-cadherin signaling events:
N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1)
→
N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1)
(modification, collaborate)
Haÿ et al., Mol Cell Biol 2009
Evidence: physical interaction, other species
-
NCI Pathway Database N-cadherin signaling events:
Dynactin 1 (DCTN1)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(translocation, activates)
Luo et al., J Cell Sci 2003, Kostetskii et al., Circ Res 2005, Shaw et al., Cell 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database N-cadherin signaling events:
EB1 (MAPRE1)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(translocation, activates)
Luo et al., J Cell Sci 2003, Kostetskii et al., Circ Res 2005, Shaw et al., Cell 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database N-cadherin signaling events:
None
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Gavard et al., J Cell Sci 2004, El Sayegh et al., Mol Biol Cell 2005
Evidence: mutant phenotype, assay
-
NCI Pathway Database N-cadherin signaling events:
RAC1/GDP complex (RAC1)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Gavard et al., J Cell Sci 2004, El Sayegh et al., Mol Biol Cell 2005
Evidence: mutant phenotype, assay
-
NCI Pathway Database N-cadherin signaling events:
KIF5B (KIF5B)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(translocation, activates)
Mary et al., Mol Biol Cell 2002, Chen et al., J Cell Biol 2003
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
BDNF (dimer)/TRKB complex (BDNF-NTRK2)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
N-cadherin/Ca2+/p120 catenin complex (CDH2-CTNND1)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
→
N-cadherin/Ca2+/p120 catenin complex (CDH2-CTNND1)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
(modification, collaborate)
Xu et al., J Biol Chem 2002, Xu et al., J Cell Sci 2004, Tai et al., Neuron 2007, Balsamo et al., J Cell Biol 1998
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
N-cadherin/Ca2+/p120 catenin complex (CDH2-CTNND1)
(modification, collaborate)
Xu et al., J Biol Chem 2002, Xu et al., J Cell Sci 2004, Tai et al., Neuron 2007, Balsamo et al., J Cell Biol 1998
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
→
N-cadherin/Ca2+/p120 catenin complex (CDH2-CTNND1)
(modification, collaborate)
Xu et al., J Biol Chem 2002, Xu et al., J Cell Sci 2004, Tai et al., Neuron 2007, Balsamo et al., J Cell Biol 1998
-
NCI Pathway Database N-cadherin signaling events:
Fer (FER)
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/Fer complex (CDH2-CTNNB1-CTNNA1-CTNND1-FER)
(modification, activates)
Lee et al., J Cell Biol 2008
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
Slit/Robo/c-Abl/Cables complex (SLIT1-ROBO1-ABL1-CABLES1)
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Rhee et al., Nat Cell Biol 2002, Rhee et al., Nat Cell Biol 2007
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Rhee et al., Nat Cell Biol 2002, Rhee et al., Nat Cell Biol 2007
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
N-cadherin/p120 catenin complex (CDH2-CTNND1)
(modification, collaborate)
Rhee et al., Nat Cell Biol 2002, Rhee et al., Nat Cell Biol 2007
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Rhee et al., Nat Cell Biol 2002, Rhee et al., Nat Cell Biol 2007
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/p120 catenin complex (CDH2-CTNND1)
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Rhee et al., Nat Cell Biol 2002, Rhee et al., Nat Cell Biol 2007
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Rhee et al., Nat Cell Biol 2002, Rhee et al., Nat Cell Biol 2007
Evidence: assay, physical interaction
-
NCI Pathway Database N-cadherin signaling events:
None
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Charrasse et al., J Cell Biol 2002, Comunale et al., Biol Cell 2007
Evidence: assay, other species
-
NCI Pathway Database N-cadherin signaling events:
RHOA/GDP complex (RHOA)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Charrasse et al., J Cell Biol 2002, Comunale et al., Biol Cell 2007
Evidence: assay, other species
-
NCI Pathway Database N-cadherin signaling events:
RAC1-CDC42/GDP complex (RAC1_CDC42)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Meriane et al., Mol Biol Cell 2000, Charrasse et al., J Cell Biol 2002, Comunale et al., Biol Cell 2007
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database N-cadherin signaling events:
None
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Meriane et al., Mol Biol Cell 2000, Charrasse et al., J Cell Biol 2002, Comunale et al., Biol Cell 2007
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
sN-cad (CDH2)
→
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
sN-cad (CDH2)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
ADAM10 (ADAM10)
→
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, activates)
Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
ADAM10 (ADAM10)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, activates)
Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
→
None
(modification, collaborate)
Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
N-cadherin/Ca2+/p120 catenin complex (CDH2-CTNND1)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
HGF(dimer)/MET(dimer) complex (MET)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
N-cadherin/Ca2+/p120 catenin complex (CDH2-CTNND1)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cad-CTF2 (CDH2)
→
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Marambaud et al., Cell 2003, Uemura et al., Neurosci Lett 2006, Uemura et al., Biochem Biophys Res Commun 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cad-CTF2 (CDH2)
→
beta catenin-gamma catenin (CTNNB1/JUP)
(modification, collaborate)
Marambaud et al., Cell 2003, Uemura et al., Neurosci Lett 2006, Uemura et al., Biochem Biophys Res Commun 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Marambaud et al., Cell 2003, Uemura et al., Neurosci Lett 2006, Uemura et al., Biochem Biophys Res Commun 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
→
beta catenin-gamma catenin (CTNNB1/JUP)
(modification, collaborate)
Marambaud et al., Cell 2003, Uemura et al., Neurosci Lett 2006, Uemura et al., Biochem Biophys Res Commun 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Marambaud et al., Cell 2003, Uemura et al., Neurosci Lett 2006, Uemura et al., Biochem Biophys Res Commun 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database N-cadherin signaling events:
None
→
N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1)
(modification, collaborate)
Wahl et al., J Biol Chem 2003, Miyatani et al., Science 1989, Shirayoshi et al., EMBO J 1986, Tamura et al., Neuron 1998
Evidence: assay, physical interaction
-
NCI Pathway Database N-cadherin signaling events:
None
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Wahl et al., J Biol Chem 2003, Miyatani et al., Science 1989, Shirayoshi et al., EMBO J 1986, Tamura et al., Neuron 1998
Evidence: assay, physical interaction
-
NCI Pathway Database N-cadherin signaling events:
N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1)
→
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Wahl et al., J Biol Chem 2003, Miyatani et al., Science 1989, Shirayoshi et al., EMBO J 1986, Tamura et al., Neuron 1998
Evidence: assay, physical interaction
-
NCI Pathway Database N-cadherin signaling events:
N-cadherin/p120 catenin/beta catenin-gamma catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1_JUP-CTNNA1)
→
None
(modification, collaborate)
Wahl et al., J Biol Chem 2003, Xu et al., J Cell Sci 2004, Knudsen et al., J Cell Biol 1992, Lévesque et al., Presse Med 1991, Miyatani et al., Science 1989, Shirayoshi et al., EMBO J 1986, Shapiro et al., Nature 1995, Tamura et al., Neuron 1998
Evidence: physical interaction
-
NCI Pathway Database N-cadherin signaling events:
N-cadherin/p120 catenin/beta catenin-gamma catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1_JUP-CTNNA1)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Wahl et al., J Biol Chem 2003, Xu et al., J Cell Sci 2004, Knudsen et al., J Cell Biol 1992, Lévesque et al., Presse Med 1991, Miyatani et al., Science 1989, Shirayoshi et al., EMBO J 1986, Shapiro et al., Nature 1995, Tamura et al., Neuron 1998
Evidence: physical interaction
-
NCI Pathway Database N-cadherin signaling events:
None
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Wahl et al., J Biol Chem 2003, Xu et al., J Cell Sci 2004, Knudsen et al., J Cell Biol 1992, Lévesque et al., Presse Med 1991, Miyatani et al., Science 1989, Shirayoshi et al., EMBO J 1986, Shapiro et al., Nature 1995, Tamura et al., Neuron 1998
Evidence: physical interaction
-
Reactome Reaction:
CDH2
→
CTNNB1
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CTNNB1
—
CDH2
(physical association, affinity chromatography technology)
Sadot et al., J Cell Sci 2002*
-
IRef Biogrid Interaction:
CTNNB1
—
CDH2
(physical association, affinity chromatography technology)
Wahl et al., J Biol Chem 2003
-
IRef Biogrid Interaction:
CTNNB1
—
CDH2
(physical association, affinity chromatography technology)
Straub et al., J Cell Sci 2003*
-
IRef Biogrid Interaction:
CTNNB1
—
CDH2
(physical association, affinity chromatography technology)
Fischer et al., J Cell Biochem 2002*
-
IRef Dip Interaction:
CTNNB1
—
CDH2
(physical association, anti bait coimmunoprecipitation)
Cooper et al., Proc Natl Acad Sci U S A 2008*
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Laura et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
CTNNB1
—
CDH2
(in vitro)
Coussen et al., J Neurosci 2002*, Wahl et al., J Biol Chem 2003, Iden et al., EMBO Rep 2006
-
IRef Innatedb Interaction:
Complex of DUSP26-CDH2-CTNNB1-KIF3A
(unknown, -)
Tanuma et al., Oncogene 2009*
-
IRef Intact Interaction:
CTNNB1
—
CDH2
(physical association, pull down)
Iden et al., EMBO Rep 2006
-
IRef Intact Interaction:
CTNNB1
—
CDH2
(physical association, anti bait coimmunoprecipitation)
Cabrera et al., J Biol Chem 2011*
-
IRef Ophid Interaction:
CTNNB1
—
CDH2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
CTNNB1
—
CDH2
(aggregation, confirmational text mining)
Laura et al., J Biol Chem 2002*
Text-mined interactions from Literome
Kurth et al., Dev Dyn 1999
:
Overexpression of myc tagged maternal
cadherin leads to a proportionate increase of the level of
beta-catenin ... Expression of
cadherin is
essential for the stable presence of
beta-catenin , as depletion from maternal cadherin mRNA leads to a complete loss of beta-catenin from the blastomeres
Hugh et al., Int J Cancer 1999
(Colonic Neoplasms...) :
beta-catenin plays a fundamental role in the regulation of the
E-cadherin-catenin cell adhesion complex
Gradl et al., Mol Cell Biol 1999
:
beta-Catenin stabilizes the
cadherin cell adhesion complex but, as a component of the Wnt/Wg signaling pathway, also controls gene expression by forming a heterodimer with a transcription factor of the LEF-TCF family
Stewart et al., J Biol Chem 2000
:
Differential regulation of endogenous
cadherin expression in Madin-Darby canine kidney cells by cell-cell adhesion and
activation of
beta -catenin signaling ... To investigate a
role of
beta-catenin in regulation of
cadherin expression in MDCK cells, we examined the effects of expressing signaling-active beta-catenin mutants ( DeltaGSK, DeltaN90, and DeltaN131 )
Imai et al., Development 2000
:
( 3 ) Downregulation of (
beta)-catenin induced by the overexpression of
cadherin resulted in the suppression of endoderm cell differentiation
Goichberg et al., J Cell Sci 2001
:
These results suggest that increased
cadherin mediated adhesion and translocation of
beta-catenin to adherens junctions are involved in activating the early steps of myogenic differentiation
Demunter et al., Mod Pathol 2002
(Disease Progression...) :
beta-Catenin plays a fundamental role in the regulation of the
E-cadherin-catenin cell adhesion complex
Ionescu et al., Microcirculation 2003
:
In the absence of PMNs, the cross linking of
VE-cadherin , but not platelet endothelial cell adhesion molecule-1 or intercellular adhesion molecule-1,
increased the cytoplasmic accumulation of
beta-catenin
Ohira et al., Proc Natl Acad Sci U S A 2003
(Lung Neoplasms) :
Drosophila
DE-cadherin is
regulated by
Wnt/beta-catenin signaling, although this has not been demonstrated in mammalian cells
Roitbak et al., Mol Biol Cell 2004
(Polycystic Kidney Diseases) :
Increased cell surface
N-cadherin in the disease cells in turn
stabilized the continued plasma membrane localization of
beta-catenin in the absence of E-cadherin
Gottardi et al., J Cell Biol 2004
:
Beta-catenin plays essential roles in both cell-cell adhesion and Wnt signal transduction, but what precisely
controls beta-catenin targeting to
cadherin adhesive complexes, or T-cell factor ( TCF ) -transcriptional complexes is less well understood
Pacquelet et al., J Cell Biol 2005
:
We found that ( 1 ) although linking DE-cadherin to alpha-catenin is essential, regulation of the link is not required in any of these types of adhesion ; ( 2 )
beta-catenin is
required only to link
DE-cadherin to alpha-catenin ; and ( 3 ) the cytoplasmic domain of DE-cadherin has an additional specific function for the invasive migration of border cells, which is conserved to other cadherins
Fukunaga et al., Cell Struct Funct 2005
:
Loss of both
beta-catenin and plakoglobin expression, however, severely
affected the strong cell adhesion activity of
cadherin
Qi et al., Mol Biol Cell 2006
(Melanoma) :
In in vitro binding assays, Src mediated phosphorylation of the
N-cadherin cytoplasmic domain
results in a significant reduction in
beta-catenin binding
Uemura et al., Biochem Biophys Res Commun 2006
:
The expression of Ncad/CTF2 in neuronal cells led to its translocation to the nucleus, and caused a prominent enhancement of cytoplasmic and nuclear beta-catenin levels in a cell-cell contact dependent manner, via following mechanisms : 1, inhibition of beta-catenin phosphorylation ; 2, transactivation of beta-catenin ; and 3,
inhibition of
N-cadherin transcription, and finally enhanced
beta-catenin nuclear signaling
Pon et al., Mol Endocrinol 2006
:
We further showed that ectopic expression of
N-cadherin was
sufficient to recruit
beta-catenin to the plasma membrane, thereby blocking beta-catenin/TCF mediated transactivation in gonadotropin treated cells
Quasnichka et al., Circ Res 2006
(Vascular Diseases) :
In summary, we have demonstrated that increasing
N-cadherin and
inhibiting beta-catenin/TCF signaling reduces VSMC proliferation, decreases the expression of cyclin D1 and increases levels of the cell cycle inhibitor, p21
Sharma et al., J Biol Chem 2007
:
Transient overexpression of IQGAP1 or
N-cadherin increased
beta-catenin at membrane ruffles
Okuda et al., Proc Natl Acad Sci U S A 2007
:
The normal glutamatergic synaptic response is maintained by postsynaptic
beta-catenin in a
cadherin dependent manner and requires the C-terminal PDZ binding motif of beta-catenin but not the link to the actin cytoskeleton
Genelhu et al., Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2007
(Adenoma, Pleomorphic...) :
Beta-catenin plays a central role in
cadherin/catenin cell-cell adhesion complex and is involved in cell signaling pathway
McCusker et al., Mol Biol Cell 2009
:
Additionally, cleavage of
cadherin-11 does not
affect binding to
beta-catenin and downstream signaling events
Haÿ et al., Mol Cell Biol 2009
:
We show here a novel mechanism by which the adhesion molecule
N-cadherin interacts with the Wnt coreceptor LRP5 and
regulates canonical
Wnt/beta-catenin signaling in osteoblasts ...
N-cadherin overexpression in osteoblasts
increases N-cadherin-LRP5 interaction, causing increased
beta-catenin degradation and altered TCF/LEF transcription in response to Wnt3a ... These data indicate that a previously unrecognized
N-cadherin-axin-LRP5 interaction negatively
regulates Wnt/beta-catenin signaling and is critical in the regulation of osteoblast function, bone formation, and bone mass
Farina et al., PloS one 2009
(Breast Neoplasms...) :
Post-transcriptional
regulation of
cadherin-11 expression by GSK-3 and
beta-catenin in prostate and breast cancer cells
Hierholzer et al., Dev Dyn 2010
:
We found that
beta-catenin is
required for the correct localization of
N-cadherin at the membrane of neural ectodermal cells and that its absence causes a disintegration of the neural tube
Zhang et al., Dev Cell 2010
:
N-cadherin engagement
activates beta-catenin signaling via Akt, suggesting a mechanism through which cells in tissues can regulate their development
Zhang et al., Neural development 2013
:
AKT activation by
N-cadherin regulates
beta-catenin signaling and neuronal differentiation during cortical development
Miller et al., J Cell Biol 1997
:
Consistent with the hypothesis that it is this pool of non-membrane associated beta-catenin that signals in the presence of membrane tethered beta-catenin, overexpression of
cadherin , which binds free beta-catenin,
blocks the axis inducing activity of membrane- tethered
beta-catenin
Sadot et al., Proc Natl Acad Sci U S A 1998
:
We studied the
effect of
N-cadherin , and its free or membrane anchored cytoplasmic domain, on the level and localization of
beta-catenin and on its ability to induce lymphocyte enhancer binding factor 1 ( LEF-1 ) -responsive transactivation ...
N-cadherin directed
beta-catenin into adherens junctions, and the chimeric protein induced diffuse distribution of beta-catenin along the membrane whereas the cytoplasmic domain of N-cadherin colocalized with beta-catenin in the nucleus