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ANGPT2 — TNF

Text-mined interactions from Literome

Yokoyama et al., Am J Physiol 1999 : To determine whether ANG II as well as mechanical stress affect the production of tumor necrosis factor (TNF) in the heart, neonatal rat cardiac myocytes and fibroblasts were cultured separately and treated for 6 h with ANG II, lipopolysaccharide (LPS), or cyclic mechanical stretch
Scott et al., J Rheumatol 2002 (Arthritis, Rheumatoid) : In contrast, TNF-alpha and TGF-beta had no effect on Ang-2 expression in RSF, but augmented expression of Ang-2 in normal synovial fibroblasts
Kalra et al., Circulation 2002 : Previous studies suggest that angiotensin II (Ang II) upregulates the expression of tumor necrosis factor (TNF) in nonmyocyte cell types ; however, the effect of Ang II on TNF expression in the adult mammalian heart is not known
Zhao et al., Clin Chim Acta 2003 (Coronary Disease) : Ang II did not significantly trigger TNF-alpha secretion in both groups
Wijayagunawardane et al., Biol Reprod 2003 : The results of the present study provide, to our knowledge, the first direct evidence that TNFalpha stimulates PG, ET-1, and Ang II secretion and that up-regulation of the TNFalpha system occurs in the cow oviduct during the periovulatory period
Arenas et al., Am J Physiol Cell Physiol 2004 : ANG II increased TNF-alpha mRNA and protein expression and the release of bioactive TNF-alpha ... To elucidate whether endogenous TNF-alpha could mediate the effects of ANG II on MMP-2 release, cells were pretreated with anti-TNF-alpha neutralizing antibodies or pentoxifylline ( an inhibitor of TNF-alpha synthesis )
Yuan et al., Oral Dis 2004 (Gingival Diseases...) : The effects of tumor necrosis factor-alpha (TNF-alpha) on the transcription of Ang-2 were tested in endothelial cells by reverse transcriptase-polymerase chain reaction
Lehmann et al., Bone 2005 : In vitro assessment of cultured fracture callus cells in comparison to primary articular chondrocytes showed that TNF-alpha treatment specifically induced the expression of MMP9, MMP14, VEGI, and Angiopoietin 2
Shah et al., Trends Pharmacol Sci 2006 (Kidney Diseases) : Ang II causes renal lesions through the activation of tumor necrosis factor (TNF)-alpha converting enzyme ( TACE, also called a disintegrin and a metalloproteinase domain 17 ) and the release of transforming growth factor (TGF)-alpha, which binds to and activates the epidermal growth factor receptor
Mateo et al., Blood 2007 : Stimulation of human umbilical arterial endothelial cells ( HUAECs ) or isolated human mononuclear cells with 1 microM Ang-II caused increased TNFalpha mRNA expression and protein
Wei et al., Am J Physiol Endocrinol Metab 2008 (Insulin Resistance) : Moreover, ANG II treatment of L6 myotubes induced NF-kappaB activation and TNF-alpha production and decreased insulin stimulated Akt activation and GLUT-4 glucose transporter translocation to plasma membranes
Tsubakimoto et al., Arterioscler Thromb Vasc Biol 2009 (Atherosclerosis) : c-Fms expression in HSCs/promonocytes was mainly regulated by TNF-alpha derived from BM CD45 ( - ) CD34 ( - ) stromal cells, and Ang II specifically regulated the TNF-alpha synthesis and release from BM stromal cells
Guo et al., J Interferon Cytokine Res 2011 : Ang II not only induced the production of tumor necrosis factor-a , IL-1ß, IL-6, and IL-10 but also increased the release of ROS
Rosa et al., Inflamm Res 2012 : Losartan dampened the effects of Ang II on TNF-a production throughout the experimental period, demonstrating an AT(1) receptor contribution
Tzepi et al., J Pharmacol Exp Ther 2012 (Pseudomonas Infections...) : Serum TNF-a levels were reduced by Ang-2 , whereas those of interleukin (IL)-6 and IL-10 remained unchanged
Yuan et al., Int J Artif Organs 2012 : TNF-a up-regulated the gene expression of VEGF, Angiopoietin-2 , and Tie2 ( p < 0.05 )
Duerrschmid et al., J Mol Cell Cardiol 2013 (Cardiomegaly...) : In this study, we demonstrate that in vitro, using a human monocyte-to-fibroblast differentiation model, Ang-II required the presence of tumor necrosis factor-alpha (TNF) to induce fibroblast maturation from monocytes
Takeda et al., J Clin Endocrinol Metab 1996 : Tumor necrosis factor reduced ANG II- and potassium induced aldosterone synthesis and CYP11B2 mRNA levels