Lara-Marquez et al., Nitric Oxide 2002
:
While cytokine exposure resulted in a significant increase in iNOS mRNA expression in these cells ( 109 plus minus 9 fold ), HB-EGF reduced iNOS expression by 5.7-fold ( P < 0.05 )
Mehta et al., J Immunol 2005
(MAP Kinase Signaling System) :
Small interfering RNA of PI3K also reversed the inhibitory effect of HB-EGF on iNOS expression