Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ VEGFA ▸ IL5 ▸ IL21 ▸ IL18 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL7 ▸ IL22 ▸ TLR9 ▸
CD40 ▸ FGB ▸ IL32 ▸ IL11 ▸ CCL2 ▸ INS ▸ IL15 ▸
IL19 ▸ IL24 ▸ JAK2 ▸ IL31 ▸ IL16 ▸ IL9 ▸ JUN ▸
IL25 ▸ IL6ST ▸ IL20 ▸ IL34 ▸ IL26 ▸ SOCS3 ▸ NOS2 ▸
IL27 ▸ IL37 ▸ TLR7 ▸ TLR5 ▸ TLR1 ▸ STAT1 ▸ TLR8 ▸
TLR10 ▸ TLR6 ▸ PTH ▸ IL12B ▸ SOAT1 ▸ SAA1 ▸ CSRP1 ▸
IL1RN ▸ AKT2 ▸ JAK1 ▸ AKT3 ▸ FOS ▸ AKT1 ▸ LEP ▸
CD79A ▸ LRPPRC ▸ IL12A ▸ VIP ▸ PIK3CA ▸ PIK3R1 ▸ RNF19A ▸
CRK ▸ LTA ▸ MMP1 ▸ CD40LG ▸ LIF ▸ LEO1 ▸ WDR61 ▸
CDC73 ▸ CTR9 ▸ PTX3 ▸ ADCYAP1 ▸ PAF1 ▸ PRKAA2 ▸ PRKAB1 ▸
PRKAA1 ▸ PRKAB2 ▸ PRKAG2 ▸ PRKAG1 ▸ FGF2 ▸ IL6R ▸ HGF ▸
GP5 ▸ PTX4 ▸ GP2 ▸ GP9 ▸ GP6 ▸ MYLIP ▸ EDN1 ▸
MMP9 ▸ MMP3 ▸ IGF1 ▸ TCF3 ▸ CRH ▸ JAK3 ▸ MMP2 ▸
GRAP2 ▸ TCF4 ▸ TCF21 ▸ TCF12 ▸ TCF25 ▸ TCF19 ▸ TCF20 ▸
TCF7 ▸ CISH ▸ TCF15 ▸ MYD88 ▸ TCF24 ▸ TCF23 ▸ CD4 ▸
MMP13 ▸ CA2 ▸ IFNB1 ▸ TGFB3 ▸ PLG ▸ MCL1 ▸ A2M ▸
TGFB2 ▸ NOS3 ▸ TIMP1 ▸ PAM ▸ AHSA1 ▸ OSM ▸ HP ▸
NOS1 ▸ CD14 ▸ PTBP2 ▸ CEBPB ▸ CD46 ▸ HNRNPF ▸ HNRNPH1 ▸
PTBP1 ▸ HMGB1 ▸ PGF ▸ ALB ▸ CSF1 ▸ AR ▸ CASP3 ▸
NOX4 ▸ NFKBIA ▸ NA ▸ MT3 ▸ STAT5A ▸ APOB ▸ PI3 ▸
PRG2 ▸ S100A12 ▸ PRG3 ▸ PRG4 ▸ TAT ▸ TNFSF11 ▸ CASP14 ▸
CASP9 ▸ NOX5 ▸ CASP1 ▸ CASP12 ▸ CASP4 ▸ CASP16 ▸ CASP5 ▸
PRKACG ▸ PRKAR2B ▸ NOX3 ▸ CASP8 ▸ CASP10 ▸ CASP7 ▸ PRKACB ▸
PRKAR2A ▸ NOX1 ▸ PRKAR1B ▸ CASP2 ▸ PRKAR1A ▸ NGF ▸ CASP6 ▸
CSF3 ▸ GPI ▸ LPA ▸ ITIH4 ▸ PDGFB ▸ FOXP3 ▸ POLDIP2 ▸
PRL ▸ FAS ▸ MT4 ▸ SOCS1 ▸ VCAM1 ▸ ANGPT2 ▸ SOD3 ▸
SELE ▸ CYP19A1 ▸ SOD1 ▸ CD8A ▸ SYT1 ▸ MMP10 ▸ MMP7 ▸
MMP14 ▸ SAA2 ▸ FASLG ▸ MMP11 ▸ SPP1 ▸ CALM3 ▸ NUP43 ▸
APP ▸ PLA2G1B ▸ SOD2 ▸ IFI44 ▸ TNFRSF11B ▸ ANG ▸ MMP12 ▸
HMOX1 ▸ CEBPA ▸ MMP8 ▸ IRF1 ▸ LBP ▸ BCL2 ▸ IKBKB ▸
PTPN11 ▸ EGF ▸ FCER2 ▸ CPOX ▸ HDAC1 ▸ MMP26 ▸ CTSB ▸
SERPINE1 ▸ MMP16 ▸ MMP15 ▸ MMP21 ▸ ADIPOQ ▸ MMP17 ▸ NAALADL1 ▸
MMP28 ▸ CD28 ▸ MMP19 ▸ LPL ▸ SETBP1 ▸ F2RL1 ▸ CALML3 ▸
MMP24 ▸ MMP20 ▸ CCL3 ▸ MMP27 ▸ MMP25 ▸ ALG1 ▸ SERPINA3 ▸
CSK ▸ FGF1 ▸ PLA2G4A ▸ MSH6 ▸ BCL3 ▸ FGF4 ▸ GFAP ▸
HDAC2 ▸ AGT ▸ MIF ▸ MSH3 ▸ GH1 ▸ LTF ▸ SAA4 ▸
PRDX2 ▸ FGF7 ▸ AGTR2 ▸ PTHLH ▸ PTPRC ▸ HES1 ▸ IRAK4 ▸
FGF23 ▸ ERVK-6 ▸ PPARG ▸ IL23A ▸ NPS ▸ APC ▸ BCL6 ▸
MAP3K7 ▸ TYR ▸ FGF6 ▸ FGF3 ▸ CUL1 ▸ IL2RA ▸ ABCC1 ▸
FGF16 ▸ PPARA ▸ CREB3 ▸ CHUK ▸ CREB5 ▸ SKP1 ▸ MTX1 ▸
FGF11 ▸ FGF21 ▸ MSH5 ▸ F2R ▸ PDLIM7 ▸ FGF13 ▸ FGF17 ▸
CREB1 ▸ FGF22 ▸ FGF8 ▸ TP53 ▸ FGF18 ▸ CEACAM5 ▸ IFNA2 ▸
FGF12 ▸ FGF20 ▸ FGF10 ▸ FGF19 ▸ KITLG ▸ IL1R1 ▸ MSH2 ▸
LTB ▸ FGF9 ▸ FGF14 ▸ IGF2 ▸ SMAD3 ▸ MSH4 ▸ FGF5 ▸
SST ▸ CXCL12 ▸ ESR1 ▸ HES4 ▸ BMP2 ▸ PTK7 ▸ IFNA1 ▸
TRAF6 ▸ IFNA7 ▸ IFNA14 ▸ ANXA1 ▸ IFNA21 ▸ PTK6 ▸ CD44 ▸
SMAD2 ▸ EGFR ▸ CCL5 ▸ RHO ▸ IFNA16 ▸ HES5 ▸ IFNA8 ▸
TXN ▸ PTK2 ▸ EPO ▸ MAP2K1 ▸ HSPD1 ▸ IFNA6 ▸ IFNA5 ▸
MTOR ▸ UCN ▸ CD8B ▸ MPO ▸ HES3 ▸ MRXS5 ▸ IFNA10 ▸
CDKN1A ▸ HES7 ▸ IFNA17 ▸ IFNA4 ▸ IFNA13 ▸ HES6 ▸ CEBPD ▸
HES2 ▸ SMAD7 ▸ KLK3 ▸ STAT4 ▸ BAX ▸ RBBP7 ▸ IKBKG ▸
CXCL10 ▸ WNK1 ▸ RBBP4 ▸ ANPEP ▸ SP1 ▸ NPY ▸ MAP2K4 ▸
HSPB1 ▸ AVP ▸ SMAD4 ▸ HAMP ▸ NAMPT ▸ CNTN2 ▸ FCGR1A ▸
CXCL1 ▸ C4BPA ▸ P2RX7 ▸ MUC1 ▸ PRKCA ▸ CAV3 ▸ IDO1 ▸
RENBP ▸ CNTF ▸ CAV2 ▸ TFPI ▸ CAV1 ▸ PAEP ▸ JUND ▸
ADCY3 ▸ ADCY10 ▸ S100B ▸ SMAD6 ▸ HIF1A ▸ DDIT3 ▸ NOD2 ▸
CAT ▸ BMP6 ▸ NPPA ▸ MBP ▸ ADCY6 ▸ SAP130 ▸ NOD1 ▸
ACE ▸ TNFRSF1B ▸ CSE ▸ ADCY1 ▸ ARID4B ▸ SMAD9 ▸ CHAT ▸
NPEPPS ▸ CCR5 ▸ SUDS3 ▸ BMP7 ▸ SHC1 ▸ SMAD5 ▸ ADM ▸
ADCY7 ▸ WNT5A ▸ CD86 ▸ IFI27 ▸ CLEC7A ▸ ADCY4 ▸ REL ▸
DUSP1 ▸ MET ▸ RAG2 ▸ GCG ▸ STS ▸ CORT ▸ NM ▸
IL17RA ▸ TNFRSF1A ▸ SAP30 ▸ IRF3 ▸ RAG1 ▸ HDC ▸ SRC ▸
ADCY8 ▸ HLA-DRA ▸ MUC4 ▸ SYK ▸ BCL10 ▸ ADCY2 ▸ GIF ▸
ACP2 ▸ IRS1 ▸ ADCY9 ▸ SELL ▸ SMAD1 ▸ IRAK1 ▸ TAB1 ▸
HLA-DRB1 ▸ PDCD11 ▸ SIN3A ▸ TGFA ▸ SELP ▸ GZMB ▸ ADCY5 ▸
AGTR1 ▸ CD5 ▸ CYP3A4 ▸ MUC12 ▸ PLD1 ▸ IBD7 ▸ IBD4 ▸
NCAM1 ▸ CYP3A ▸ ICOSLG ▸ ANXA6 ▸ PLD2 ▸ MUC22 ▸ MUC20 ▸
ATF3 ▸ IGFBP1 ▸ ABCB1 ▸ ITGB1 ▸ TYK2 ▸ VAV1 ▸ ZFP36 ▸
MUC13 ▸ HSF1 ▸ IBD8 ▸ BMP1 ▸ OPRM1 ▸ REG1A ▸ PPP2CA ▸
PTPN4 ▸ RETN ▸ PDGFA ▸ INA ▸ ICAM3 ▸ MUC17 ▸ IRF4 ▸
BCL9 ▸ EIF2AK2 ▸ AHR ▸ MUC16 ▸ IL17F ▸ MUC6 ▸ MAP2K5 ▸
PGP ▸ IRAK3 ▸ TPO ▸ ADORA1 ▸ IBD5 ▸ CR2 ▸ UTP15 ▸
MAP2K6 ▸ MUC19 ▸ ARSA ▸ MUC8 ▸ IBD6 ▸ HSPG2 ▸ CTF1 ▸
UTP18 ▸ S100A9 ▸ MUC21 ▸ UTP20 ▸ TF ▸ MUC15 ▸ SEA ▸
CYP1A1 ▸ S100A8 ▸ CCND1 ▸ IL17D ▸ MPG ▸ CTGF ▸ GRB2 ▸
CTSL ▸ ICAM2 ▸ BCL5 ▸ TNFSF13B ▸ SFTPC ▸ MAP2K3 ▸ POMC ▸
ICAM4 ▸ ATP8A2 ▸ MAP2K7 ▸ UTP3 ▸ CCL20 ▸ APOE ▸ EDN2 ▸
MUC7 ▸ TNFRSF8 ▸ MOG ▸ CXCL17 ▸ ST2 ▸ IBD3 ▸ UTP23 ▸
MAP2K2 ▸ FGFR3 ▸ MUC2 ▸ NLRP3 ▸ EDN3 ▸ PTGS1 ▸ LGALS1 ▸
UTP6 ▸ HSP90AB1 ▸ PIGA ▸ ICAM5 ▸ HRAS ▸ SETD2 ▸ IBD9 ▸
IBD2 ▸ BTRC ▸ HMGCR ▸ HCL1 ▸ EPS8 ▸ THBD ▸ IRF5 ▸
C5AR1 ▸ XRCC1 ▸ MPL ▸ BPI ▸ PITX2 ▸ PGD ▸ CD1D ▸
FUT4 ▸ ETS2 ▸ EPX ▸ BMP3 ▸ GPX7 ▸ PARP14 ▸ CD19 ▸
PARP15 ▸ BCR ▸ BMP10 ▸ SLPI ▸ TEC ▸ HPD ▸ GPX3 ▸
CX3CR1 ▸ OPN1LW ▸ PLD4 ▸ CA1 ▸ C1QB ▸ CD163 ▸ BTK ▸
CLU ▸ CD2 ▸ IGFBP3 ▸ LYN ▸ CTSS ▸ FXYD1 ▸ KNG1 ▸
GYS1 ▸ CPB2 ▸ OAS3 ▸ MAPKAPK2 ▸ ITGAM ▸ OAS1 ▸ EPS15 ▸
PDCD4 ▸ WNT4 ▸ PCK1 ▸ CXCR4 ▸ C1orf228 ▸ TRPV1 ▸ PPP2R2B ▸
SCARB1 ▸ CPB1 ▸ TRAF2 ▸ HSP90AA1 ▸ ROR1 ▸ TRNAI1 ▸ GPX6 ▸
PIM1 ▸ CCL1 ▸ DNMT1 ▸ FXR1 ▸ GPX1 ▸ PPP2R1A ▸ PLD3 ▸
BGLAP ▸ CYP1A2 ▸ ABL1 ▸ HSPB3 ▸ LCN2 ▸ TIMP2 ▸ PTS ▸
PARK2 ▸ GPX4 ▸ PARP11 ▸ HCK ▸ PARP1 ▸ HCL2 ▸ PARP4 ▸
PARP6 ▸ NFATC2 ▸ TGM2 ▸ ATP5O ▸ PARP12 ▸ PARP2 ▸ TNPO1 ▸
ESR2 ▸ GYS2 ▸ ACHE ▸ BMP15 ▸ NEUROD2 ▸ RPL17 ▸ CRYGEP ▸
HSPA5 ▸ SERPINF1 ▸ FOXO3 ▸ NEUROD1 ▸ GPX2 ▸ GPX5 ▸ NDP ▸
TSLP ▸ HCL3 ▸ PARP10 ▸ IRF9 ▸ PARP9 ▸ PLD6 ▸ PARP16 ▸
NTF3 ▸ CSH2 ▸ FXR2 ▸ IDS ▸ MAF ▸ GAL ▸ BMP4 ▸
BMP5 ▸ EBP ▸ CIB1 ▸ CXCL6 ▸ CD80 ▸ GNA13 ▸ NEUROD4 ▸
GHRH ▸ ADORA3 ▸ PARP8 ▸ C1QA ▸ PARP3 ▸ ANGPT1 ▸ XBP1 ▸
HDAC3 ▸ IL1R2 ▸ UCN2 ▸ ETS1 ▸ IRF8 ▸ ATP7A ▸ GNRH1 ▸
MS4A1 ▸ AHSG ▸ GTF2B ▸ NNMT ▸ PON1 ▸ NEUROD6 ▸ GPX8 ▸
CHGA ▸ PLD5 ▸ HDAC6 ▸ WNT10B ▸ OAS2 ▸ ADH6 ▸ NT5E ▸
SMC3 ▸ CXCL5 ▸ MYC ▸ ITGA4 ▸ BLVRB ▸ TNC ▸ BAI2 ▸
PC ▸ CEBPZ ▸ PDCD5 ▸ SFTPA1 ▸ PTPN22 ▸ PHB ▸ PDCD6 ▸
RAB7B ▸ MKL1 ▸ TRD ▸ RAB7A ▸ SERPINA1 ▸ NTN1 ▸ OXA1L ▸
AIF1 ▸ COQ4 ▸ ADIPOR1 ▸ KDR ▸ NANOG ▸ CHP2 ▸ TSC22D3 ▸
TIMP3 ▸ CXCL3 ▸ RBP4 ▸ STK31 ▸ COQ6 ▸ IRAK2 ▸ IRG1 ▸
COQ2 ▸ MYO10 ▸ CRAT ▸ C5 ▸ NLRC5 ▸ GSTM3 ▸ CXCL14 ▸
STK35 ▸ HDAC4 ▸ ITGA5 ▸ CD69 ▸ HBD ▸ CCL4 ▸ ADH4 ▸
KLRB1 ▸ STK24 ▸ COQ5 ▸ MUC5AC ▸ ACD ▸ PINK1 ▸ CPA1 ▸
HDAC10 ▸ MTA2 ▸ STEAP4 ▸ SMN1 ▸ ACR ▸ CXCL13 ▸ AMELX ▸
P2RX1 ▸ NPY4R ▸ TSN ▸ CD34 ▸ CD59 ▸ SCG2 ▸ CDH1 ▸
QRICH2 ▸ EREG ▸ RLN1 ▸ CALM2 ▸ MCC ▸ NOTCH2 ▸ HDAC9 ▸
CD1C ▸ ADH7 ▸ RAC1 ▸ GAS6 ▸ DERL1 ▸ KRT37 ▸ CREBBP ▸
TGM4 ▸ STK40 ▸ COL1A1 ▸ SAA3P ▸ GSTM5 ▸ LRG1 ▸ PLA2G2D ▸
KRT10 ▸ CDK4 ▸ EEF1A2 ▸ ICOS ▸ FYN ▸ TRAF5 ▸ STK36 ▸
HCFC1 ▸ IGFBP7 ▸ CALCA ▸ SPN ▸ SMC6 ▸ ATF1 ▸ IL2RG ▸
RORC ▸ RNASE3 ▸ TTR ▸ PLAT ▸ MAP3K3 ▸ TFAP2A ▸ STK11 ▸
TNFAIP6 ▸ MYO16 ▸ WNT6 ▸ FGL1 ▸ UCN3 ▸ FMR1 ▸ TBP ▸
THBS1 ▸ CD38 ▸ STK19 ▸ STK25 ▸ IGF1R ▸ LDLR ▸ SLC25A3 ▸
DEFB4B ▸ CHP1 ▸ TRAF1 ▸ P2RY6 ▸ ACE2 ▸ MYO6 ▸ VIMP ▸
GSTM2 ▸ IL2RB ▸ SERPING1 ▸ CP ▸ C3AR1 ▸ PARK7 ▸ PRNP ▸
RLN3 ▸ LGALS3 ▸ SARS ▸ CXCL9 ▸ HDAC5 ▸ WNT11 ▸ STK4 ▸
WNT16 ▸ TBCC ▸ APOA4 ▸ AREG ▸ HDAC7 ▸ E2F1 ▸ ABCG2 ▸
ACSM3 ▸ BAI3 ▸ STK16 ▸ COQ9 ▸ CXCL11 ▸ MYO19 ▸ CDKN1B ▸
NR4A1 ▸ CNR2 ▸ ASIP ▸ IGFBP5 ▸ SCG3 ▸ LYZ ▸ SDC1 ▸
MTA3 ▸ CDK9 ▸ MAL ▸ JUNB ▸ BAI1 ▸ RPS6KA3 ▸ CD33 ▸
AD5 ▸ SLC33A1 ▸ AZU1 ▸ BSG ▸ SCG5 ▸ TGM7 ▸ FLOT2 ▸
ACAN ▸ NTF4 ▸ KRT13 ▸ IL1RAP ▸ NOTCH1 ▸ CCR2 ▸ ADH5 ▸
IGFBP2 ▸ CX3CL1 ▸ CCR6 ▸ ITGA2B ▸ PDCD2 ▸ TAC3 ▸ NTS ▸
TAC4 ▸ MSC ▸ TIRAP ▸ XIAP ▸ WAS ▸ STK38 ▸ CXCR3 ▸
ADAM17 ▸ PTK2B ▸ CD274 ▸ VWF ▸ DEFB114 ▸ WNT1 ▸ PSMB9 ▸
GIP ▸ ATF4 ▸ HDAC11 ▸ RABEPK ▸ TRAF3IP2 ▸ PPP5C ▸ PDAP1 ▸
IRF2 ▸ QRICH1 ▸ ABCA4 ▸ NMU ▸ PDCD1 ▸ STK33 ▸ VHLL ▸
ARG2 ▸ CEACAM1 ▸ VCP ▸ COQ7 ▸ WNT2 ▸ ROR2 ▸ ECM2 ▸
GCLC ▸ STK39 ▸ GSTM4 ▸ GAST ▸ IGFBP4 ▸ IRF7 ▸ FGFR2 ▸
EDNRA ▸ RUNX2 ▸ CCK ▸ CCR1 ▸ TNFSF10 ▸ CXCL16 ▸ SERPINA6 ▸
SERPINE2 ▸ RB1 ▸ ECM1 ▸ PDCD7 ▸ MTA1 ▸ SLC39A14 ▸ FLT3LG ▸
MCS ▸ BDNF ▸ PIAS3 ▸ CALM1 ▸ STK10 ▸ APCS ▸ HPX ▸
MIP ▸ LCAT ▸ CDKN2A ▸ SMC5 ▸ KRT38 ▸ NR0B1 ▸ RASIP1 ▸
PCK2 ▸ STK3 ▸ SMC2 ▸ HDAC8 ▸ MEPE ▸ REN ▸ MIA ▸
GSTM1 ▸ DYNLRB1 ▸ POU5F1 ▸ MICE ▸ SOS1 ▸ COQ3 ▸ TAC1 ▸
CXCL2 ▸ SP3 ▸ WNT3 ▸ ARG1 ▸ ANGPT4 ▸ EGR1 ▸ HSPB8 ▸
SERPINB5 ▸ SMC4 ▸ IFIT1 ▸ OXTR ▸ PDCD10 ▸ RAF1 ▸ RLN2 ▸
PTGER4 ▸ PRKD1 ▸ NFKB2 ▸ MEOX2 ▸ GCSAM ▸ ZBTB16 ▸ F12 ▸
ERBB3 ▸ PTPRE ▸ FOXO1 ▸ PIAS1 ▸ SH3GL2 ▸ PIK3C3 ▸ KAT2B ▸
CBL ▸ HNRNPA1 ▸
Data information
Please see the Gene Interactions Track Manual.