Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ VEGFA ▸ IL5 ▸ IL21 ▸ IL18 ▸
TLR3 ▸ IL33 ▸ ICAM1 ▸ PTGS2 ▸ IL7 ▸ IL22 ▸ TLR9 ▸
CD40 ▸ FGB ▸ IL32 ▸ INS ▸ CCL2 ▸ IL11 ▸ IL15 ▸
IL19 ▸ IL24 ▸ JAK2 ▸ IL31 ▸ IL9 ▸ IL6ST ▸ IL16 ▸
IL20 ▸ IL25 ▸ IL34 ▸ IL26 ▸ JUN ▸ NOS2 ▸ IL27 ▸
SOCS3 ▸ IL37 ▸ TLR7 ▸ TLR5 ▸ TLR1 ▸ STAT1 ▸ TLR8 ▸
TLR6 ▸ TLR10 ▸ IL12B ▸ PTH ▸ SOAT1 ▸ SAA1 ▸ IL1RN ▸
CSRP1 ▸ AKT3 ▸ JAK1 ▸ FOS ▸ AKT1 ▸ AKT2 ▸ LEP ▸
CD79A ▸ LRPPRC ▸ IL12A ▸ VIP ▸ PIK3CA ▸ RNF19A ▸ PIK3R1 ▸
LTA ▸ CRK ▸ CTR9 ▸ MMP1 ▸ CD40LG ▸ ADCYAP1 ▸ PAF1 ▸
PTX3 ▸ WDR61 ▸ LIF ▸ CDC73 ▸ LEO1 ▸ IL6R ▸ PRKAA1 ▸
PRKAG2 ▸ FGF2 ▸ PRKAB2 ▸ PRKAB1 ▸ PRKAG1 ▸ PRKAA2 ▸ GP5 ▸
HGF ▸ GP6 ▸ GP9 ▸ GP2 ▸ PTX4 ▸ IGF1 ▸ EDN1 ▸
MMP3 ▸ MYLIP ▸ MMP9 ▸ GRAP2 ▸ JAK3 ▸ MMP2 ▸ CRH ▸
TCF3 ▸ CISH ▸ TCF21 ▸ CD4 ▸ TCF15 ▸ TCF7 ▸ TCF25 ▸
TCF20 ▸ TCF4 ▸ TCF24 ▸ TCF12 ▸ TCF19 ▸ TCF23 ▸ MYD88 ▸
IFNB1 ▸ CA2 ▸ TGFB3 ▸ MMP13 ▸ MCL1 ▸ PLG ▸ NOS3 ▸
TGFB2 ▸ A2M ▸ OSM ▸ PAM ▸ TIMP1 ▸ AHSA1 ▸ HP ▸
CD14 ▸ NOS1 ▸ PGF ▸ HNRNPF ▸ HNRNPH1 ▸ PTBP1 ▸ CD46 ▸
CEBPB ▸ HMGB1 ▸ PTBP2 ▸ NOX4 ▸ NA ▸ APOB ▸ CASP3 ▸
STAT5A ▸ MT3 ▸ ALB ▸ NFKBIA ▸ AR ▸ CSF1 ▸ PRG4 ▸
PRG2 ▸ TNFSF11 ▸ PI3 ▸ S100A12 ▸ TAT ▸ PRG3 ▸ CASP16 ▸
CASP7 ▸ CASP14 ▸ PRKAR2A ▸ PRKACB ▸ CASP1 ▸ CASP2 ▸ CASP6 ▸
CASP5 ▸ NGF ▸ CASP9 ▸ PRKAR1A ▸ NOX5 ▸ PRKAR1B ▸ CASP8 ▸
CASP10 ▸ NOX1 ▸ CASP12 ▸ PRKACG ▸ NOX3 ▸ CASP4 ▸ PRKAR2B ▸
CSF3 ▸ FAS ▸ POLDIP2 ▸ LPA ▸ SOCS1 ▸ ITIH4 ▸ GPI ▸
FOXP3 ▸ ANGPT2 ▸ MT4 ▸ PDGFB ▸ PRL ▸ VCAM1 ▸ SYT1 ▸
SOD1 ▸ MMP11 ▸ SELE ▸ MMP14 ▸ CALM3 ▸ CD8A ▸ SOD3 ▸
MMP10 ▸ SAA2 ▸ SPP1 ▸ FASLG ▸ CYP19A1 ▸ MMP7 ▸ MMP8 ▸
MMP12 ▸ LBP ▸ IKBKB ▸ IRF1 ▸ IFI44 ▸ PLA2G1B ▸ BCL2 ▸
NUP43 ▸ APP ▸ TNFRSF11B ▸ HMOX1 ▸ PTPN11 ▸ CEBPA ▸ SOD2 ▸
ANG ▸ SETBP1 ▸ MMP24 ▸ MMP17 ▸ CCL3 ▸ MMP16 ▸ CPOX ▸
FCER2 ▸ LPL ▸ MMP28 ▸ CALML3 ▸ EGF ▸ MMP26 ▸ MMP15 ▸
MMP25 ▸ MMP19 ▸ MMP21 ▸ MMP20 ▸ ADIPOQ ▸ F2RL1 ▸ CTSB ▸
ALG1 ▸ HDAC1 ▸ CD28 ▸ NAALADL1 ▸ SERPINE1 ▸ MMP27 ▸ APC ▸
GFAP ▸ AGT ▸ MSH3 ▸ GH1 ▸ TYR ▸ IRAK4 ▸ ERVK-6 ▸
FGF7 ▸ SERPINA3 ▸ FGF1 ▸ BCL6 ▸ BCL3 ▸ MSH6 ▸ FGF4 ▸
PTHLH ▸ PRDX2 ▸ HES1 ▸ MAP3K7 ▸ CSK ▸ LTF ▸ IL23A ▸
HDAC2 ▸ PLA2G4A ▸ AGTR2 ▸ NPS ▸ PTPRC ▸ MIF ▸ PPARG ▸
SAA4 ▸ FGF23 ▸ LTB ▸ FGF9 ▸ MSH5 ▸ KITLG ▸ CREB5 ▸
SKP1 ▸ FGF21 ▸ MTX1 ▸ FGF17 ▸ FGF5 ▸ PDLIM7 ▸ FGF10 ▸
FGF12 ▸ FGF14 ▸ MSH2 ▸ FGF20 ▸ SMAD3 ▸ FGF16 ▸ IL2RA ▸
FGF6 ▸ FGF18 ▸ CEACAM5 ▸ CREB1 ▸ IGF2 ▸ IL1R1 ▸ FGF22 ▸
ABCC1 ▸ FGF3 ▸ CREB3 ▸ TP53 ▸ IFNA2 ▸ FGF11 ▸ PPARA ▸
MSH4 ▸ F2R ▸ FGF19 ▸ FGF13 ▸ CUL1 ▸ FGF8 ▸ CHUK ▸
ESR1 ▸ CEBPD ▸ IFNA16 ▸ TXN ▸ HES4 ▸ HSPD1 ▸ EPO ▸
PTK2 ▸ HES5 ▸ IFNA17 ▸ IFNA14 ▸ IFNA5 ▸ MPO ▸ IFNA21 ▸
MAP2K1 ▸ HES7 ▸ UCN ▸ CXCL12 ▸ MRXS5 ▸ SMAD2 ▸ HES3 ▸
IFNA13 ▸ CDKN1A ▸ CD44 ▸ IFNA1 ▸ SST ▸ IFNA8 ▸ HES6 ▸
CD8B ▸ TRAF6 ▸ IFNA6 ▸ ANXA1 ▸ IFNA10 ▸ PTK7 ▸ HES2 ▸
CCL5 ▸ EGFR ▸ MTOR ▸ RHO ▸ IFNA4 ▸ BMP2 ▸ PTK6 ▸
IFNA7 ▸ C4BPA ▸ NPY ▸ CXCL1 ▸ HAMP ▸ CNTF ▸ SMAD4 ▸
RBBP7 ▸ NAMPT ▸ CAV3 ▸ PRKCA ▸ P2RX7 ▸ AVP ▸ PAEP ▸
CAV2 ▸ TFPI ▸ HSPB1 ▸ STAT4 ▸ CNTN2 ▸ ANPEP ▸ CAV1 ▸
IDO1 ▸ BAX ▸ SP1 ▸ IKBKG ▸ CXCL10 ▸ MUC1 ▸ FCGR1A ▸
MAP2K4 ▸ RBBP4 ▸ RENBP ▸ KLK3 ▸ SMAD7 ▸ WNK1 ▸ MET ▸
NM ▸ ARID4B ▸ TGFA ▸ CAT ▸ ADCY1 ▸ SAP130 ▸ MUC4 ▸
SELP ▸ NPPA ▸ TAB1 ▸ ADCY10 ▸ RAG1 ▸ CCR5 ▸ CLEC7A ▸
NOD2 ▸ SMAD5 ▸ TNFRSF1B ▸ SMAD9 ▸ BMP6 ▸ SIN3A ▸ CSE ▸
WNT5A ▸ ADCY4 ▸ ADCY7 ▸ HLA-DRA ▸ IRAK1 ▸ IFI27 ▸ ADM ▸
SMAD1 ▸ SELL ▸ GIF ▸ STS ▸ IRF3 ▸ ADCY9 ▸ CHAT ▸
TNFRSF1A ▸ AGTR1 ▸ ACP2 ▸ SMAD6 ▸ GZMB ▸ SAP30 ▸ PDCD11 ▸
ADCY2 ▸ IRS1 ▸ ADCY5 ▸ SHC1 ▸ IL17RA ▸ JUND ▸ SRC ▸
HLA-DRB1 ▸ CD86 ▸ BCL10 ▸ CD5 ▸ DDIT3 ▸ CYP3A4 ▸ REL ▸
SYK ▸ ADCY3 ▸ GCG ▸ CORT ▸ DUSP1 ▸ RAG2 ▸ HIF1A ▸
ADCY8 ▸ NOD1 ▸ ADCY6 ▸ BMP7 ▸ HDC ▸ S100B ▸ SUDS3 ▸
MBP ▸ ACE ▸ NPEPPS ▸ PTGS1 ▸ ARSA ▸ IRAK3 ▸ MAP2K2 ▸
CCL20 ▸ IL17D ▸ BCL5 ▸ MUC7 ▸ CR2 ▸ UTP15 ▸ BTRC ▸
TPO ▸ MUC21 ▸ CYP3A ▸ MUC6 ▸ UTP18 ▸ ICAM5 ▸ CYP1A1 ▸
IBD3 ▸ EDN2 ▸ INA ▸ PLD1 ▸ EIF2AK2 ▸ ANXA6 ▸ IBD4 ▸
ATP8A2 ▸ MAP2K6 ▸ EDN3 ▸ IBD9 ▸ PDGFA ▸ BMP1 ▸ CTSL ▸
HSPG2 ▸ TNFSF13B ▸ MUC16 ▸ HMGCR ▸ UTP6 ▸ MAP2K3 ▸ MUC13 ▸
UTP20 ▸ RETN ▸ PLD2 ▸ PGP ▸ HRAS ▸ ST2 ▸ CCND1 ▸
REG1A ▸ ICAM2 ▸ S100A9 ▸ S100A8 ▸ GRB2 ▸ NCAM1 ▸ PTPN4 ▸
MUC12 ▸ TF ▸ CTGF ▸ IBD8 ▸ ABCB1 ▸ MUC22 ▸ ATF3 ▸
AHR ▸ SETD2 ▸ MUC15 ▸ BCL9 ▸ IBD6 ▸ ZFP36 ▸ VAV1 ▸
ITGB1 ▸ SEA ▸ IL17F ▸ UTP23 ▸ MUC19 ▸ MUC20 ▸ MUC17 ▸
MPG ▸ TNFRSF8 ▸ LGALS1 ▸ SFTPC ▸ IBD2 ▸ IBD5 ▸ POMC ▸
IRF4 ▸ CXCL17 ▸ CTF1 ▸ IGFBP1 ▸ OPRM1 ▸ MAP2K7 ▸ TYK2 ▸
MUC2 ▸ APOE ▸ HSF1 ▸ HSP90AB1 ▸ MAP2K5 ▸ ADORA1 ▸ ICAM3 ▸
FGFR3 ▸ PPP2CA ▸ IBD7 ▸ NLRP3 ▸ MUC8 ▸ UTP3 ▸ ICOSLG ▸
MOG ▸ PIGA ▸ ICAM4 ▸ EPX ▸ GPX1 ▸ IRF9 ▸ CXCR4 ▸
EBP ▸ CD2 ▸ C5AR1 ▸ CXCL6 ▸ TRNAI1 ▸ XBP1 ▸ PITX2 ▸
MPL ▸ PARP12 ▸ HCK ▸ ACHE ▸ PLD4 ▸ PARP1 ▸ CX3CR1 ▸
ATP5O ▸ PARP15 ▸ TEC ▸ PARP10 ▸ TSLP ▸ HSPA5 ▸ PARP9 ▸
EPS15 ▸ PPP2R2B ▸ BMP10 ▸ GNRH1 ▸ NEUROD2 ▸ HSP90AA1 ▸ KNG1 ▸
SLPI ▸ PARP3 ▸ CCL1 ▸ BPI ▸ GPX3 ▸ BCR ▸ UCN2 ▸
ABL1 ▸ HDAC3 ▸ ATP7A ▸ MAPKAPK2 ▸ GPX5 ▸ IDS ▸ WNT10B ▸
PON1 ▸ OAS3 ▸ CD163 ▸ CTSS ▸ SERPINF1 ▸ PTS ▸ WNT4 ▸
HCL2 ▸ ESR2 ▸ OPN1LW ▸ NFATC2 ▸ BMP3 ▸ GPX6 ▸ OAS1 ▸
C1QA ▸ FXR1 ▸ PARK2 ▸ NEUROD1 ▸ TRPV1 ▸ PPP2R1A ▸ XRCC1 ▸
BMP5 ▸ CD19 ▸ OAS2 ▸ PGD ▸ ROR1 ▸ PDCD4 ▸ CD80 ▸
HDAC6 ▸ HSPB3 ▸ CIB1 ▸ PARP16 ▸ PARP8 ▸ GYS1 ▸ NEUROD6 ▸
HPD ▸ AHSG ▸ CLU ▸ BTK ▸ ETS2 ▸ CYP1A2 ▸ PLD3 ▸
GPX4 ▸ FXR2 ▸ HCL1 ▸ GPX8 ▸ NTF3 ▸ TGM2 ▸ ETS1 ▸
ANGPT1 ▸ LCN2 ▸ PARP2 ▸ GHRH ▸ PARP4 ▸ CA1 ▸ PIM1 ▸
ITGAM ▸ FUT4 ▸ NNMT ▸ TNPO1 ▸ HCL3 ▸ LYN ▸ EPS8 ▸
TIMP2 ▸ IL1R2 ▸ C1orf228 ▸ MS4A1 ▸ CPB2 ▸ IRF8 ▸ GNA13 ▸
CRYGEP ▸ C1QB ▸ MAF ▸ CHGA ▸ PCK1 ▸ BMP4 ▸ DNMT1 ▸
GPX7 ▸ NDP ▸ ADORA3 ▸ GYS2 ▸ CPB1 ▸ GTF2B ▸ PARP14 ▸
IRF5 ▸ PARP6 ▸ PLD6 ▸ TRAF2 ▸ GPX2 ▸ PARP11 ▸ PLD5 ▸
CD1D ▸ FXYD1 ▸ GAL ▸ SCARB1 ▸ RPL17 ▸ CSH2 ▸ FOXO3 ▸
BMP15 ▸ THBD ▸ IGFBP3 ▸ BGLAP ▸ NEUROD4 ▸ FLT3LG ▸ MKL1 ▸
CREBBP ▸ SAA3P ▸ SFTPA1 ▸ ACAN ▸ PCK2 ▸ LRG1 ▸ SMC6 ▸
PDCD1 ▸ RPS6KA3 ▸ NPY4R ▸ CHP1 ▸ COQ6 ▸ IGFBP5 ▸ WNT11 ▸
SERPINE2 ▸ IRF2 ▸ HDAC4 ▸ IGFBP2 ▸ VCP ▸ CALM1 ▸ HDAC11 ▸
NTF4 ▸ APOA4 ▸ STK16 ▸ STK11 ▸ ACD ▸ PDCD6 ▸ BSG ▸
CDH1 ▸ UCN3 ▸ TBCC ▸ ATF1 ▸ MEPE ▸ COQ2 ▸ POU5F1 ▸
STEAP4 ▸ EEF1A2 ▸ TNFAIP6 ▸ FLOT2 ▸ MYO10 ▸ SMC3 ▸ GAST ▸
TGM4 ▸ TRAF1 ▸ DYNLRB1 ▸ BDNF ▸ HBD ▸ CHP2 ▸ MUC5AC ▸
RLN3 ▸ STK4 ▸ CCR2 ▸ KLRB1 ▸ NANOG ▸ VWF ▸ CD33 ▸
MAL ▸ CCL4 ▸ COQ5 ▸ CD38 ▸ GIP ▸ ADH5 ▸ CXCL16 ▸
RABEPK ▸ RUNX2 ▸ SLC33A1 ▸ TBP ▸ NR4A1 ▸ SCG3 ▸ ICOS ▸
WNT2 ▸ AMELX ▸ CPA1 ▸ P2RX1 ▸ IFIT1 ▸ STK25 ▸ SERPING1 ▸
CXCL13 ▸ KRT13 ▸ SERPINA1 ▸ OXTR ▸ P2RY6 ▸ PTPN22 ▸ BAI1 ▸
ADH6 ▸ AIF1 ▸ TRAF5 ▸ THBS1 ▸ GSTM1 ▸ IGF1R ▸ DEFB4B ▸
GSTM2 ▸ CCK ▸ MIA ▸ TGM7 ▸ HDAC9 ▸ CXCL14 ▸ AZU1 ▸
NTS ▸ TIMP3 ▸ QRICH1 ▸ LCAT ▸ ADIPOR1 ▸ PC ▸ OXA1L ▸
CXCL9 ▸ STK40 ▸ PDCD5 ▸ PSMB9 ▸ PDAP1 ▸ CRAT ▸ STK19 ▸
NR0B1 ▸ NT5E ▸ CD34 ▸ GAS6 ▸ STK35 ▸ MCS ▸ GCLC ▸
LYZ ▸ WNT6 ▸ RB1 ▸ CXCL2 ▸ ADAM17 ▸ AREG ▸ SPN ▸
CXCR3 ▸ SLC39A14 ▸ ACSM3 ▸ ACR ▸ PLA2G2D ▸ AD5 ▸ ASIP ▸
CD274 ▸ MYO6 ▸ CEBPZ ▸ TFAP2A ▸ PIAS3 ▸ CEACAM1 ▸ CXCL3 ▸
CD1C ▸ STK38 ▸ MIP ▸ NOTCH1 ▸ CXCL5 ▸ RBP4 ▸ TTR ▸
HDAC5 ▸ STK10 ▸ TSN ▸ MYC ▸ KRT37 ▸ CD59 ▸ RLN1 ▸
HPX ▸ ROR2 ▸ IGFBP4 ▸ COQ9 ▸ FMR1 ▸ KDR ▸ SCG2 ▸
TRAF3IP2 ▸ ARG2 ▸ PHB ▸ ECM1 ▸ CDK4 ▸ MTA1 ▸ TAC1 ▸
STK3 ▸ SDC1 ▸ KRT38 ▸ ABCG2 ▸ GSTM3 ▸ IGFBP7 ▸ CCR1 ▸
C5 ▸ E2F1 ▸ RAC1 ▸ TNC ▸ ITGA5 ▸ HDAC10 ▸ SMN1 ▸
EDNRA ▸ PRNP ▸ MYO19 ▸ FYN ▸ SMC5 ▸ WNT3 ▸ STK31 ▸
RAF1 ▸ MYO16 ▸ RNASE3 ▸ ACE2 ▸ DERL1 ▸ TNFSF10 ▸ ATF4 ▸
IL2RB ▸ CCR6 ▸ IL1RAP ▸ IRG1 ▸ MTA2 ▸ PLAT ▸ RORC ▸
CP ▸ EGR1 ▸ CXCL11 ▸ HSPB8 ▸ COQ4 ▸ NTN1 ▸ MICE ▸
EREG ▸ ANGPT4 ▸ CNR2 ▸ PDCD7 ▸ PINK1 ▸ VIMP ▸ BLVRB ▸
CX3CL1 ▸ TIRAP ▸ COL1A1 ▸ LGALS3 ▸ PDCD2 ▸ IRF7 ▸ SCG5 ▸
STK33 ▸ PTK2B ▸ APCS ▸ ECM2 ▸ TSC22D3 ▸ SLC25A3 ▸ WNT1 ▸
COQ3 ▸ MCC ▸ LDLR ▸ NMU ▸ CDK9 ▸ SERPINB5 ▸ FGL1 ▸
VHLL ▸ RASIP1 ▸ ARG1 ▸ REN ▸ HCFC1 ▸ JUNB ▸ ITGA2B ▸
IRAK2 ▸ ABCA4 ▸ BAI2 ▸ QRICH2 ▸ GSTM5 ▸ GSTM4 ▸ FGFR2 ▸
ADH4 ▸ MSC ▸ PPP5C ▸ STK39 ▸ TAC4 ▸ SMC2 ▸ STK36 ▸
ITGA4 ▸ WNT16 ▸ MTA3 ▸ IL2RG ▸ TRD ▸ HDAC8 ▸ NOTCH2 ▸
CD69 ▸ C3AR1 ▸ CALM2 ▸ COQ7 ▸ PDCD10 ▸ SOS1 ▸ NLRC5 ▸
STK24 ▸ BAI3 ▸ RAB7A ▸ PARK7 ▸ CDKN1B ▸ RLN2 ▸ XIAP ▸
KRT10 ▸ TAC3 ▸ DEFB114 ▸ CDKN2A ▸ WAS ▸ SERPINA6 ▸ HDAC7 ▸
SARS ▸ SP3 ▸ SMC4 ▸ RAB7B ▸ CALCA ▸ MAP3K3 ▸ ADH7 ▸
KAT2B ▸ CBL ▸ SH3GL2 ▸ PTGER4 ▸ F12 ▸ PTPRE ▸ PIAS1 ▸
ERBB3 ▸ HNRNPA1 ▸ MEOX2 ▸ GCSAM ▸ FOXO1 ▸ PRKD1 ▸ PIK3C3 ▸
ZBTB16 ▸ NFKB2 ▸
Data information
Please see the Gene Interactions Track Manual.