Gene interactions and pathways from curated databases and text-mining
Cell 1994, PMID: 7954831

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor.

Pasteris, N G; Cadle, A; Logie, L J; Porteous, M E; Schwartz, C E; Stevenson, R E; Glover, T W; Wilroy, R S; Gorski, J L

Faciogenital dysplasia (FGDY), also known as Aarskog-Scott syndrome, is an X-linked developmental disorder characterized by disproportionately short stature and by facial, skeletal, and urogenital anomalies. Molecular genetic analyses mapped FGDY to chromosome Xp11.21. To clone this gene, YAC clones spanning an FGDY-specific translocation breakpoint were isolated. An isolated cDNA, FGD1, is disrupted by the breakpoint, and FGD1 mutations cosegregate with the disease. FGD1 codes for a 961 amino acid protein that has strong homology to Rho/Rac guanine nucleotide exchange factors (GEFs), contains a cysteine-rich zinc finger-like region, and, like the RasGEF mSos, contains two potential SH3-binding sites. These results provide compelling evidence that FGD1 is responsible for FGDY and suggest that FGD1 is a Rho/RacGEF involved in mammalian development.

Diseases/Pathways annotated by Medline MESH: Abnormalities, Multiple, Translocation, Genetic, Urogenital Abnormalities
Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: TRIO → RHOJ (reaction)
  • Reactome Reaction: RHOF → NGEF (reaction)
  • Reactome Reaction: RHOBTB2 → TIAM1 (reaction)
  • Reactome Reaction: RHOB → FGD3 (reaction)
  • Reactome Reaction: RHOBTB1 → OBSCN (reaction)
  • Reactome Reaction: RAC2 → ITSN1 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF4 (reaction)
  • Reactome Reaction: RHOA → NGEF (reaction)
  • Reactome Reaction: RHOBTB1 → KALRN (reaction)
  • Reactome Reaction: RAC2 → ARHGEF16 (reaction)
  • Reactome Reaction: RHOD → ARHGEF3 (reaction)
  • Reactome Reaction: RHOBTB1 → NGEF (reaction)
  • Reactome Reaction: RHOF → ARHGEF11 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF2 (reaction)
  • Reactome Reaction: RHOQ → MCF2 (reaction)
  • Reactome Reaction: RHOV → TRIO (reaction)
  • Reactome Reaction: FGD3 → RHOT1 (reaction)
  • Reactome Reaction: RHOA → SOS2 (reaction)
  • Reactome Reaction: RHOQ → ARHGEF16 (reaction)
  • Reactome Reaction: TIAM1 → RHOT1 (reaction)
  • Reactome Reaction: RHOF → MCF2 (reaction)
  • Reactome Reaction: RHOQ → ARHGEF7 (reaction)
  • Reactome Reaction: RAC2 → TRIO (reaction)
  • Reactome Reaction: RHOBTB2 → NGEF (reaction)
  • Reactome Reaction: VAV1 → RHOT1 (reaction)
  • Reactome Reaction: RHOBTB1 → VAV2 (reaction)
  • Reactome Reaction: RHOG → ECT2 (reaction)
  • Reactome Reaction: RHOA → TRIO (reaction)
  • Reactome Reaction: RHOB → PLEKHG2 (reaction)
  • Reactome Reaction: RHOU → OBSCN (reaction)
  • Reactome Reaction: RHOB → ARHGEF12 (reaction)
  • Reactome Reaction: RHOQ → ARHGEF12 (reaction)
  • Reactome Reaction: RHOU → FGD3 (reaction)
  • Reactome Reaction: RHOU → ARHGEF3 (reaction)
  • Reactome Reaction: RHOD → ARHGEF2 (reaction)
  • Reactome Reaction: RAC2 → NGEF (reaction)
  • Reactome Reaction: RHOA → OBSCN (reaction)
  • Reactome Reaction: RHOA → SOS1 (reaction)
  • Reactome Reaction: FGD1 → RAC3 (reaction)
  • Reactome Reaction: RHOG → SOS2 (reaction)
  • Reactome Reaction: RHOG → PLEKHG2 (reaction)
  • Reactome Reaction: ARHGEF2 → RHOU (reaction)
  • Reactome Reaction: ABR → RHOJ (reaction)
  • Reactome Reaction: NET1 → RHOJ (reaction)
  • Reactome Reaction: RHOA → ARHGEF12 (reaction)
  • Reactome Reaction: MCF2 → RHOJ (reaction)
  • Reactome Reaction: RHOB → SOS2 (reaction)
  • Reactome Reaction: RHOH → FGD2 (reaction)
  • Reactome Reaction: RHOH → VAV3 (reaction)
  • Reactome Reaction: RHOA → TIAM1 (reaction)
  • Reactome Reaction: ARHGAP4 → RHOV (reaction)
  • Reactome Reaction: RHOD → ITSN1 (reaction)
  • Reactome Reaction: RHOF → TIAM1 (reaction)
  • Reactome Reaction: RHOG → MCF2L (reaction)
  • Reactome Reaction: RAC2 → PLEKHG2 (reaction)
  • Reactome Reaction: SOS1 → RHOV (reaction)
  • Reactome Reaction: RHOJ → ARHGEF12 (reaction)
  • Reactome Reaction: RHOG → ARHGEF9 (reaction)
  • Reactome Reaction: RHOV → FGD4 (reaction)
  • Reactome Reaction: FGD2 → RHOT2 (reaction)
  • Reactome Reaction: RHOBTB2 → FGD4 (reaction)
  • Reactome Reaction: RHOG → RASGRF2 (reaction)
  • Reactome Reaction: RAC2 → MCF2L (reaction)
  • Reactome Reaction: RHOH → OBSCN (reaction)
  • Reactome Reaction: RAC3 → TRIO (reaction)
  • Reactome Reaction: RHOF → ARHGAP4 (reaction)
  • Reactome Reaction: RHOB → SOS1 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOJ (reaction)
  • Reactome Reaction: ARHGEF2 → RHOT2 (reaction)
  • Reactome Reaction: RHOG → ARHGEF3 (reaction)
  • Reactome Reaction: RHOG → SOS1 (reaction)
  • Reactome Reaction: RHOH → ARHGEF12 (reaction)
  • Reactome Reaction: RHOC → ARHGEF18 (reaction)
  • Reactome Reaction: RHOQ → TRIO (reaction)
  • Reactome Reaction: ARHGEF9 → RHOU (reaction)
  • Reactome Reaction: RHOD → VAV1 (reaction)
  • Reactome Reaction: SOS1 → RHOT2 (reaction)
  • Reactome Reaction: RHOD → NGEF (reaction)
  • Reactome Reaction: RHOC → TIAM2 (reaction)
  • Reactome Reaction: RHOG → ARHGEF4 (reaction)
  • Reactome Reaction: RHOC → ARHGEF12 (reaction)
  • Reactome Reaction: RHOD → NET1 (reaction)
  • Reactome Reaction: RHOV → NET1 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOV (reaction)
  • Reactome Reaction: TIAM1 → RHOJ (reaction)
  • Reactome Reaction: FGD1 → RHOBTB2 (reaction)
  • Reactome Reaction: RHOF → ARHGEF18 (reaction)
  • Reactome Reaction: RAC3 → PLEKHG5 (reaction)
  • Reactome Reaction: RHOG → ITSN1 (reaction)
  • Reactome Reaction: RHOBTB1 → MCF2L (reaction)
  • Reactome Reaction: SOS1 → RHOT1 (reaction)
  • Reactome Reaction: RHOBTB2 → OBSCN (reaction)
  • Reactome Reaction: RHOT1 → NGEF (reaction)
  • Reactome Reaction: RHOA → FGD2 (reaction)
  • Reactome Reaction: RHOC → MCF2L (reaction)
  • Reactome Reaction: RHOC → VAV2 (reaction)
  • Reactome Reaction: RHOG → FGD4 (reaction)
  • Reactome Reaction: RHOQ → SOS1 (reaction)
  • Reactome Reaction: SOS2 → RHOJ (reaction)
  • Reactome Reaction: FGD1 → RAC2 (reaction)
  • Reactome Reaction: RHOC → FGD2 (reaction)
  • Reactome Reaction: RHOC → ARHGEF11 (reaction)
  • Reactome Reaction: RAC2 → ARHGEF3 (reaction)
  • Reactome Reaction: RHOA → AKAP13 (reaction)
  • Reactome Reaction: AKAP13 → RHOT1 (reaction)
  • Reactome Reaction: RHOB → VAV2 (reaction)
  • Reactome Reaction: RHOF → KALRN (reaction)
  • Reactome Reaction: RAC3 → NGEF (reaction)
  • Reactome Reaction: RHOBTB1 → FGD4 (reaction)
  • Reactome Reaction: RHOU → NGEF (reaction)
  • Reactome Reaction: RHOT1 → ARHGEF4 (reaction)
  • Reactome Reaction: RHOD → OBSCN (reaction)
  • Reactome Reaction: RHOC → VAV1 (reaction)
  • Reactome Reaction: FGD1 → RHOG (reaction)
  • Reactome Reaction: RHOU → TIAM2 (reaction)
  • Reactome Reaction: RHOBTB1 → NET1 (reaction)
  • Reactome Reaction: RHOF → TRIO (reaction)
  • Reactome Reaction: RHOQ → KALRN (reaction)
  • Reactome Reaction: RHOD → PLEKHG2 (reaction)
  • Reactome Reaction: RHOH → TIAM2 (reaction)
  • Reactome Reaction: RHOF → NET1 (reaction)
  • Reactome Reaction: RHOG → ARHGEF16 (reaction)
  • Reactome Reaction: RHOG → ARHGEF2 (reaction)
  • Reactome Reaction: RHOBTB2 → MCF2 (reaction)
  • Reactome Reaction: VAV1 → RHOV (reaction)
  • Reactome Reaction: RAC2 → ARHGEF2 (reaction)
  • Reactome Reaction: RHOBTB2 → VAV1 (reaction)
  • Reactome Reaction: RHOD → FGD3 (reaction)
  • Reactome Reaction: RAC3 → ARHGEF18 (reaction)
  • Reactome Reaction: RHOB → VAV1 (reaction)
  • Reactome Reaction: CDC42 → OBSCN (reaction)
  • Reactome Reaction: ITSN1 → RHOT2 (reaction)
  • Reactome Reaction: ECT2 → RHOU (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF7 (reaction)
  • Reactome Reaction: VAV2 → RHOT1 (reaction)
  • Reactome Reaction: RHOC → ARHGEF4 (reaction)
  • Reactome Reaction: PLEKHG5 → CDC42 (reaction)
  • Reactome Reaction: CDC42 → NET1 (reaction)
  • Reactome Reaction: RAC2 → OBSCN (reaction)
  • Reactome Reaction: RHOF → VAV2 (reaction)
  • Reactome Reaction: RHOC → TRIO (reaction)
  • Reactome Reaction: RHOG → KALRN (reaction)
  • Reactome Reaction: ARHGEF6 → RHOQ (reaction)
  • Reactome Reaction: RHOD → PLEKHG5 (reaction)
  • Reactome Reaction: ECT2 → RHOJ (reaction)
  • Reactome Reaction: RHOBTB1 → VAV3 (reaction)
  • Reactome Reaction: RHOQ → VAV1 (reaction)
  • Reactome Reaction: RASGRF2 → RHOJ (reaction)
  • Reactome Reaction: RAC2 → SOS1 (reaction)
  • Reactome Reaction: RHOH → RASGRF2 (reaction)
  • Reactome Reaction: ABR → RHOT2 (reaction)
  • Reactome Reaction: RHOH → PLEKHG5 (reaction)
  • Reactome Reaction: RHOU → ARHGEF12 (reaction)
  • Reactome Reaction: PLEKHG5 → RHOT2 (reaction)
  • Reactome Reaction: RHOG → NET1 (reaction)
  • Reactome Reaction: RHOG → VAV3 (reaction)
  • Reactome Reaction: RHOB → ARHGEF17 (reaction)
  • Reactome Reaction: CDC42 → FGD4 (reaction)
  • Reactome Reaction: RHOU → ARHGEF7 (reaction)
  • Reactome Reaction: RAC2 → ARHGEF12 (reaction)
  • Reactome Reaction: SOS2 → RHOT1 (reaction)
  • Reactome Reaction: RHOA → PLEKHG2 (reaction)
  • Reactome Reaction: RHOBTB1 → PLEKHG2 (reaction)
  • Reactome Reaction: RHOB → TIAM1 (reaction)
  • Reactome Reaction: RHOC → KALRN (reaction)
  • Reactome Reaction: RHOBTB2 → KALRN (reaction)
  • Reactome Reaction: RAC2 → ARHGEF7 (reaction)
  • Reactome Reaction: RHOD → SOS2 (reaction)
  • Reactome Reaction: RHOQ → FGD2 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOF (reaction)
  • Reactome Reaction: FGD1 → RHOQ (reaction)
  • Reactome Reaction: SOS1 → RHOU (reaction)
  • Reactome Reaction: RHOC → ARHGAP4 (reaction)
  • Reactome Reaction: RAC3 → ARHGEF4 (reaction)
  • Reactome Reaction: FGD1 → RHOD (reaction)
  • Reactome Reaction: RHOV → ARHGEF16 (reaction)
  • Reactome Reaction: FGD1 → RHOJ (reaction)
  • Reactome Reaction: TIAM2 → RHOJ (reaction)
  • Reactome Reaction: RHOF → OBSCN (reaction)
  • Reactome Reaction: RHOA → RASGRF2 (reaction)
  • Reactome Reaction: ARHGEF18 → CDC42 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOT2 (reaction)
  • Reactome Reaction: RHOF → FGD3 (reaction)
  • Reactome Reaction: RAC3 → KALRN (reaction)
  • Reactome Reaction: RHOQ → OBSCN (reaction)
  • Reactome Reaction: MCF2L → RHOJ (reaction)
  • Reactome Reaction: RHOQ → TIAM1 (reaction)
  • Reactome Reaction: RHOD → ARHGEF18 (reaction)
  • Reactome Reaction: VAV1 → RHOJ (reaction)
  • Reactome Reaction: FGD3 → RHOJ (reaction)
  • Reactome Reaction: RHOT1 → ARHGEF3 (reaction)
  • Reactome Reaction: ARHGEF11 → RHOJ (reaction)
  • Reactome Reaction: RHOU → ITSN1 (reaction)
  • Reactome Reaction: PLEKHG5 → RHOV (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF2 (reaction)
  • Reactome Reaction: RHOD → TRIO (reaction)
  • Reactome Reaction: RHOB → NGEF (reaction)
  • Reactome Reaction: RHOQ → ARHGEF9 (reaction)
  • Reactome Reaction: ECT2 → CDC42 (reaction)
  • Reactome Reaction: RHOJ → ARHGEF4 (reaction)
  • Reactome Reaction: RHOBTB2 → PLEKHG2 (reaction)
  • Reactome Reaction: RAC2 → ARHGEF4 (reaction)
  • Reactome Reaction: RHOD → ARHGEF16 (reaction)
  • Reactome Reaction: RHOF → ARHGEF16 (reaction)
  • Reactome Reaction: RHOF → ARHGEF4 (reaction)
  • Reactome Reaction: RHOC → ABR (reaction)
  • Reactome Reaction: RHOQ → ITSN1 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOT1 (reaction)
  • Reactome Reaction: RAC3 → ECT2 (reaction)
  • Reactome Reaction: RHOBTB1 → MCF2 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF16 (reaction)
  • Reactome Reaction: RHOF → AKAP13 (reaction)
  • Reactome Reaction: RHOF → SOS1 (reaction)
  • Reactome Reaction: RHOQ → ARHGEF11 (reaction)
  • Reactome Reaction: RHOD → RASGRF2 (reaction)
  • Reactome Reaction: RHOG → OBSCN (reaction)
  • Reactome Reaction: ARHGEF17 → RHOT2 (reaction)
  • Reactome Reaction: CDC42 → NGEF (reaction)
  • Reactome Reaction: RHOQ → ARHGEF17 (reaction)
  • Reactome Reaction: RHOV → ARHGEF4 (reaction)
  • Reactome Reaction: RHOG → FGD3 (reaction)
  • Reactome Reaction: RHOT2 → NGEF (reaction)
  • Reactome Reaction: RHOA → ARHGEF7 (reaction)
  • Reactome Reaction: ARHGEF7 → RHOT1 (reaction)
  • Reactome Reaction: RHOBTB2 → ITSN1 (reaction)
  • Reactome Reaction: RHOU → KALRN (reaction)
  • Reactome Reaction: RHOT1 → ARHGEF12 (reaction)
  • Reactome Reaction: RHOD → KALRN (reaction)
  • Reactome Reaction: PLEKHG5 → RHOU (reaction)
  • Reactome Reaction: ARHGEF9 → RHOT2 (reaction)
  • Reactome Reaction: TRIO → RHOT2 (reaction)
  • Reactome Reaction: RHOA → ARHGEF3 (reaction)
  • Reactome Reaction: RHOBTB1 → RASGRF2 (reaction)
  • Reactome Reaction: RAC2 → ARHGEF18 (reaction)
  • Reactome Reaction: FGD4 → RHOJ (reaction)
  • Reactome Reaction: RHOA → ECT2 (reaction)
  • Reactome Reaction: RHOB → OBSCN (reaction)
  • Reactome Reaction: TRIO → CDC42 (reaction)
  • Reactome Reaction: RHOC → ARHGEF9 (reaction)
  • Reactome Reaction: RHOA → ITSN1 (reaction)
  • Reactome Reaction: RHOV → ARHGEF3 (reaction)
  • Reactome Reaction: KALRN → CDC42 (reaction)
  • Reactome Reaction: RHOG → PLEKHG5 (reaction)
  • Reactome Reaction: RHOF → SOS2 (reaction)
  • Reactome Reaction: RHOC → ARHGEF7 (reaction)
  • Reactome Reaction: TIAM1 → RHOU (reaction)
  • Reactome Reaction: RHOG → ARHGEF12 (reaction)
  • Reactome Reaction: RAC2 → FGD3 (reaction)
  • Reactome Reaction: TRIO → RHOT1 (reaction)
  • Reactome Reaction: CDC42 → AKAP13 (reaction)
  • Reactome Reaction: RAC3 → ITSN1 (reaction)
  • Reactome Reaction: RHOQ → FGD4 (reaction)
  • Reactome Reaction: RHOD → AKAP13 (reaction)
  • Reactome Reaction: ARHGEF2 → RHOV (reaction)
  • Reactome Reaction: RHOBTB2 → ABR (reaction)
  • Reactome Reaction: RHOC → SOS2 (reaction)
  • Reactome Reaction: RHOF → MCF2L (reaction)
  • Reactome Reaction: RHOC → ECT2 (reaction)
  • Reactome Reaction: ARHGEF11 → RHOV (reaction)
  • Reactome Reaction: RHOBTB1 → ECT2 (reaction)
  • Reactome Reaction: ARHGEF18 → RHOT2 (reaction)
  • Reactome Reaction: RHOA → ARHGEF11 (reaction)
  • Reactome Reaction: RHOU → AKAP13 (reaction)
  • Reactome Reaction: RHOQ → VAV2 (reaction)
  • Reactome Reaction: RHOA → ARHGEF2 (reaction)
  • Reactome Reaction: RHOH → ECT2 (reaction)
  • Reactome Reaction: RHOG → ARHGEF18 (reaction)
  • Reactome Reaction: SOS2 → RHOU (reaction)
  • Reactome Reaction: RAC2 → FGD2 (reaction)
  • Reactome Reaction: TIAM2 → RHOT2 (reaction)
  • Reactome Reaction: RHOF → ABR (reaction)
  • Reactome Reaction: RHOF → ARHGEF12 (reaction)
  • Reactome Reaction: CDC42 → ARHGEF16 (reaction)
  • Reactome Reaction: FGD1 → RHOU (reaction)
  • Reactome Reaction: RHOH → ABR (reaction)
  • Reactome Reaction: CDC42 → ABR (reaction)
  • Reactome Reaction: VAV2 → CDC42 (reaction)
  • Reactome Reaction: MCF2 → CDC42 (reaction)
  • Reactome Reaction: RHOH → SOS2 (reaction)
  • Reactome Reaction: RHOB → TRIO (reaction)
  • Reactome Reaction: RHOD → ECT2 (reaction)
  • Reactome Reaction: RHOB → ARHGEF4 (reaction)
  • Reactome Reaction: ARHGEF18 → RHOU (reaction)
  • Reactome Reaction: RHOT2 → ARHGEF4 (reaction)
  • Reactome Reaction: PLEKHG2 → RHOT1 (reaction)
  • Reactome Reaction: RHOB → ECT2 (reaction)
  • Reactome Reaction: CDC42 → ITSN1 (reaction)
  • Reactome Reaction: ARHGEF7 → RHOT2 (reaction)
  • Reactome Reaction: RHOBTB2 → TRIO (reaction)
  • Reactome Reaction: RHOH → PLEKHG2 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF17 (reaction)
  • Reactome Reaction: RHOQ → MCF2L (reaction)
  • Reactome Reaction: RAC3 → ARHGEF11 (reaction)
  • Reactome Reaction: ARHGAP4 → RHOT1 (reaction)
  • Reactome Reaction: RHOB → ARHGEF7 (reaction)
  • Reactome Reaction: RAC2 → TIAM2 (reaction)
  • Reactome Reaction: PLEKHG2 → RHOV (reaction)
  • Reactome Reaction: RAC3 → OBSCN (reaction)
  • Reactome Reaction: RAC3 → ARHGEF17 (reaction)
  • Reactome Reaction: RHOBTB2 → SOS1 (reaction)
  • Reactome Reaction: MCF2 → RHOT2 (reaction)
  • Reactome Reaction: CDC42 → ARHGEF4 (reaction)
  • Reactome Reaction: RAC3 → NET1 (reaction)
  • Reactome Reaction: RHOG → FGD2 (reaction)
  • Reactome Reaction: RAC2 → RASGRF2 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOB (reaction)
  • Reactome Reaction: RHOC → MCF2 (reaction)
  • Reactome Reaction: RHOU → ABR (reaction)
  • Reactome Reaction: RHOD → TIAM2 (reaction)
  • Reactome Reaction: RAC3 → ARHGEF16 (reaction)
  • Reactome Reaction: RHOF → ARHGEF7 (reaction)
  • Reactome Reaction: RHOC → PLEKHG5 (reaction)
  • Reactome Reaction: ARHGEF2 → RHOJ (reaction)
  • Reactome Reaction: RHOF → TIAM2 (reaction)
  • Reactome Reaction: RHOD → MCF2 (reaction)
  • Reactome Reaction: RHOD → ARHGEF11 (reaction)
  • Reactome Reaction: RHOB → TIAM2 (reaction)
  • Reactome Reaction: ARHGEF11 → RHOT1 (reaction)
  • Reactome Reaction: ARHGEF6 → RAC2 (reaction)
  • Reactome Reaction: RHOB → MCF2L (reaction)
  • Reactome Reaction: RHOQ → PLEKHG2 (reaction)
  • Reactome Reaction: RAC2 → KALRN (reaction)
  • Reactome Reaction: RHOA → FGD4 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF16 (reaction)
  • Reactome Reaction: RHOA → VAV2 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF9 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOC (reaction)
  • Reactome Reaction: RHOQ → ARHGEF2 (reaction)
  • Reactome Reaction: RHOB → FGD2 (reaction)
  • Reactome Reaction: RHOD → TIAM1 (reaction)
  • Reactome Reaction: RHOV → VAV3 (reaction)
  • Reactome Reaction: RHOG → VAV1 (reaction)
  • Reactome Reaction: RHOV → ARHGEF12 (reaction)
  • Reactome Reaction: RHOC → OBSCN (reaction)
  • Reactome Reaction: RHOA → VAV1 (reaction)
  • Reactome Reaction: MCF2L → RHOT1 (reaction)
  • Reactome Reaction: RHOU → FGD4 (reaction)
  • Reactome Reaction: RHOF → FGD4 (reaction)
  • Reactome Reaction: RHOH → ARHGEF7 (reaction)
  • Reactome Reaction: FGD3 → RHOT2 (reaction)
  • Reactome Reaction: RAC2 → VAV1 (reaction)
  • Reactome Reaction: RHOH → VAV2 (reaction)
  • Reactome Reaction: FGD1 → RHOH (reaction)
  • Reactome Reaction: RAC3 → ARHGEF7 (reaction)
  • Reactome Reaction: TIAM1 → RHOT2 (reaction)
  • Reactome Reaction: ARHGEF17 → CDC42 (reaction)
  • Reactome Reaction: RHOG → VAV2 (reaction)
  • Reactome Reaction: RHOA → VAV3 (reaction)
  • Reactome Reaction: RHOBTB2 → PLEKHG5 (reaction)
  • Reactome Reaction: FGD1 → RHOA (reaction)
  • Reactome Reaction: RHOF → FGD2 (reaction)
  • Reactome Reaction: RAC3 → ABR (reaction)
  • Reactome Reaction: RHOH → ARHGEF18 (reaction)
  • Reactome Reaction: RHOQ → ARHGAP4 (reaction)
  • Reactome Reaction: RHOB → ITSN1 (reaction)
  • Reactome Reaction: RAC2 → ECT2 (reaction)
  • Reactome Reaction: ARHGEF11 → RHOT2 (reaction)
  • Reactome Reaction: RHOV → FGD3 (reaction)
  • Reactome Reaction: OBSCN → RHOT1 (reaction)
  • Reactome Reaction: RHOA → ABR (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGAP4 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF12 (reaction)
  • Reactome Reaction: RASGRF2 → RHOT2 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOH (reaction)
  • Reactome Reaction: RHOV → ABR (reaction)
  • Reactome Reaction: RHOBTB2 → FGD3 (reaction)
  • Reactome Reaction: RAC2 → ARHGEF11 (reaction)
  • Reactome Reaction: RHOQ → ARHGEF4 (reaction)
  • Reactome Reaction: RHOQ → NET1 (reaction)
  • Reactome Reaction: FGD1 → RHOT2 (reaction)
  • Reactome Reaction: KALRN → RHOT1 (reaction)
  • Reactome Reaction: PLEKHG2 → CDC42 (reaction)
  • Reactome Reaction: RASGRF2 → CDC42 (reaction)
  • Reactome Reaction: RHOH → SOS1 (reaction)
  • Reactome Reaction: VAV1 → RHOT2 (reaction)
  • Reactome Reaction: ARHGEF2 → RHOT1 (reaction)
  • Reactome Reaction: RHOF → PLEKHG5 (reaction)
  • Reactome Reaction: RHOC → ARHGEF2 (reaction)
  • Reactome Reaction: ECT2 → RHOV (reaction)
  • Reactome Reaction: RHOB → VAV3 (reaction)
  • Reactome Reaction: ARHGEF17 → RHOJ (reaction)
  • Reactome Reaction: ITSN1 → RHOT1 (reaction)
  • Reactome Reaction: ARHGEF6 → CDC42 (reaction)
  • Reactome Reaction: RHOD → VAV3 (reaction)
  • Reactome Reaction: ARHGEF9 → RHOJ (reaction)
  • Reactome Reaction: RHOV → OBSCN (reaction)
  • Reactome Reaction: RHOB → ARHGEF11 (reaction)
  • Reactome Reaction: RHOC → ITSN1 (reaction)
  • Reactome Reaction: RHOC → ARHGEF3 (reaction)
  • Reactome Reaction: RHOH → ARHGEF11 (reaction)
  • Reactome Reaction: RHOG → NGEF (reaction)
  • Reactome Reaction: RHOQ → ABR (reaction)
  • Reactome Reaction: FGD1 → CDC42 (reaction)
  • Reactome Reaction: RHOF → ARHGEF2 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF3 (reaction)
  • Reactome Reaction: RHOBTB2 → ECT2 (reaction)
  • Reactome Reaction: RHOF → VAV1 (reaction)
  • Reactome Reaction: RHOC → NGEF (reaction)
  • Reactome Reaction: RHOC → VAV3 (reaction)
  • Reactome Reaction: RHOH → NGEF (reaction)
  • Reactome Reaction: RHOC → FGD3 (reaction)
  • Reactome Reaction: RAC2 → AKAP13 (reaction)
  • Reactome Reaction: RHOH → ARHGEF4 (reaction)
  • Reactome Reaction: RHOB → AKAP13 (reaction)
  • Reactome Reaction: RHOB → MCF2 (reaction)
  • Reactome Reaction: RHOU → NET1 (reaction)
  • Reactome Reaction: FGD1 → RHOB (reaction)
  • Reactome Reaction: ARHGEF16 → RHOT1 (reaction)
  • Reactome Reaction: RHOT2 → VAV3 (reaction)
  • Reactome Reaction: RHOG → AKAP13 (reaction)
  • Reactome Reaction: FGD1 → RHOT1 (reaction)
  • Reactome Reaction: RHOV → ARHGEF7 (reaction)
  • Reactome Reaction: RHOQ → RASGRF2 (reaction)
  • Reactome Reaction: RHOBTB1 → ABR (reaction)
  • Reactome Reaction: PLEKHG2 → RHOJ (reaction)
  • Reactome Reaction: RHOB → NET1 (reaction)
  • Reactome Reaction: RHOBTB1 → TRIO (reaction)
  • Reactome Reaction: RHOV → MCF2 (reaction)
  • Reactome Reaction: RHOBTB1 → PLEKHG5 (reaction)
  • Reactome Reaction: RHOT2 → FGD4 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOU (reaction)
  • Reactome Reaction: RHOBTB2 → SOS2 (reaction)
  • Reactome Reaction: RHOD → ARHGEF12 (reaction)
  • Reactome Reaction: RHOB → RASGRF2 (reaction)
  • Reactome Reaction: TIAM1 → CDC42 (reaction)
  • Reactome Reaction: RHOD → FGD2 (reaction)
  • Reactome Reaction: RHOB → ARHGEF16 (reaction)
  • Reactome Reaction: RHOB → ARHGEF2 (reaction)
  • Reactome Reaction: CDC42 → ARHGEF7 (reaction)
  • Reactome Reaction: RHOA → KALRN (reaction)
  • Reactome Reaction: CDC42 → ARHGEF3 (reaction)
  • Reactome Reaction: VAV2 → RHOT2 (reaction)
  • Reactome Reaction: VAV2 → RHOJ (reaction)
  • Reactome Reaction: RHOBTB1 → SOS1 (reaction)
  • Reactome Reaction: RHOD → ARHGEF4 (reaction)
  • Reactome Reaction: RHOB → ABR (reaction)
  • Reactome Reaction: RHOBTB2 → VAV3 (reaction)
  • Reactome Reaction: RHOB → ARHGAP4 (reaction)
  • Reactome Reaction: ARHGEF16 → RHOT2 (reaction)
  • Reactome Reaction: CDC42 → TIAM2 (reaction)
  • Reactome Reaction: RHOH → NET1 (reaction)
  • Reactome Reaction: ARHGEF11 → RHOU (reaction)
  • Reactome Reaction: RHOF → RASGRF2 (reaction)
  • Reactome Reaction: RHOBTB1 → FGD2 (reaction)
  • Reactome Reaction: ECT2 → RHOT1 (reaction)
  • Reactome Reaction: RAC2 → NET1 (reaction)
  • Reactome Reaction: RHOB → ARHGEF9 (reaction)
  • Reactome Reaction: RHOBTB1 → SOS2 (reaction)
  • Reactome Reaction: CDC42 → FGD2 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF11 (reaction)
  • Reactome Reaction: VAV1 → CDC42 (reaction)
  • Reactome Reaction: SOS2 → RHOV (reaction)
  • Reactome Reaction: RAC3 → ARHGAP4 (reaction)
  • Reactome Reaction: ARHGEF18 → RHOT1 (reaction)
  • Reactome Reaction: RHOD → ARHGEF7 (reaction)
  • Reactome Reaction: RAC3 → SOS1 (reaction)
  • Reactome Reaction: RHOH → ARHGEF17 (reaction)
  • Reactome Reaction: MCF2L → CDC42 (reaction)
  • Reactome Reaction: RHOBTB2 → VAV2 (reaction)
  • Reactome Reaction: RHOA → NET1 (reaction)
  • Reactome Reaction: RHOB → ARHGEF3 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOD (reaction)
  • Reactome Reaction: RAC3 → AKAP13 (reaction)
  • Reactome Reaction: RHOF → PLEKHG2 (reaction)
  • Reactome Reaction: AKAP13 → RHOJ (reaction)
  • Reactome Reaction: RHOH → ARHGEF9 (reaction)
  • Reactome Reaction: RHOV → TIAM2 (reaction)
  • Reactome Reaction: RHOH → FGD4 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGAP4 (reaction)
  • Reactome Reaction: RAC3 → FGD3 (reaction)
  • Reactome Reaction: RHOQ → PLEKHG5 (reaction)
  • Reactome Reaction: ARHGEF18 → RHOV (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF7 (reaction)
  • Reactome Reaction: RAC3 → VAV3 (reaction)
  • Reactome Reaction: RHOF → ITSN1 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF12 (reaction)
  • Reactome Reaction: RHOC → NET1 (reaction)
  • Reactome Reaction: KALRN → RHOJ (reaction)
  • Reactome Reaction: ARHGAP4 → RHOT2 (reaction)
  • Reactome Reaction: RHOF → ARHGEF9 (reaction)
  • Reactome Reaction: CDC42 → ARHGEF12 (reaction)
  • Reactome Reaction: RHOU → ARHGEF4 (reaction)
  • Reactome Reaction: FGD1 → RHOBTB1 (reaction)
  • Reactome Reaction: RAC3 → ARHGEF12 (reaction)
  • Reactome Reaction: RHOA → MCF2 (reaction)
  • Reactome Reaction: RAC2 → ABR (reaction)
  • Reactome Reaction: ARHGEF17 → RHOU (reaction)
  • Reactome Reaction: RHOH → KALRN (reaction)
  • Reactome Reaction: ARHGEF6 → RHOG (reaction)
  • Reactome Reaction: RHOC → RASGRF2 (reaction)
  • Reactome Reaction: RAC2 → TIAM1 (reaction)
  • Reactome Reaction: RHOA → PLEKHG5 (reaction)
  • Reactome Reaction: RHOD → ABR (reaction)
  • Reactome Reaction: RHOA → ARHGEF9 (reaction)
  • Reactome Reaction: RHOC → PLEKHG2 (reaction)
  • Reactome Reaction: RHOF → VAV3 (reaction)
  • Reactome Reaction: MCF2 → RHOT1 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF9 (reaction)
  • Reactome Reaction: RHOD → MCF2L (reaction)
  • Reactome Reaction: RAC3 → FGD2 (reaction)
  • Reactome Reaction: ARHGEF7 → RHOJ (reaction)
  • Reactome Reaction: RHOH → ARHGEF16 (reaction)
  • Reactome Reaction: NGEF → RHOJ (reaction)
  • Reactome Reaction: RHOB → KALRN (reaction)
  • Reactome Reaction: RHOV → AKAP13 (reaction)
  • Reactome Reaction: NET1 → RHOT1 (reaction)
  • Reactome Reaction: KALRN → RHOT2 (reaction)
  • Reactome Reaction: PLEKHG2 → RHOU (reaction)
  • Reactome Reaction: RHOF → ECT2 (reaction)
  • Reactome Reaction: RHOG → MCF2 (reaction)
  • Reactome Reaction: RHOH → MCF2L (reaction)
  • Reactome Reaction: RAC2 → VAV3 (reaction)
  • Reactome Reaction: RHOD → ARHGEF9 (reaction)
  • Reactome Reaction: ARHGAP4 → RHOU (reaction)
  • Reactome Reaction: RHOF → ARHGEF17 (reaction)
  • Reactome Reaction: ARHGEF6 → RAC3 (reaction)
  • Reactome Reaction: PLEKHG5 → RHOT1 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF4 (reaction)
  • Reactome Reaction: RHOT1 → VAV3 (reaction)
  • Reactome Reaction: RAC3 → PLEKHG2 (reaction)
  • Reactome Reaction: AKAP13 → RHOT2 (reaction)
  • Reactome Reaction: TIAM2 → RHOT1 (reaction)
  • Reactome Reaction: RHOF → ARHGEF3 (reaction)
  • Reactome Reaction: RAC2 → PLEKHG5 (reaction)
  • Reactome Reaction: RHOBTB1 → VAV1 (reaction)
  • Reactome Reaction: MCF2L → RHOU (reaction)
  • Reactome Reaction: RHOD → SOS1 (reaction)
  • Reactome Reaction: RAC2 → ARHGAP4 (reaction)
  • Reactome Reaction: RAC3 → ARHGEF3 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF18 (reaction)
  • Reactome Reaction: RHOBTB2 → TIAM2 (reaction)
  • Reactome Reaction: RHOG → TIAM1 (reaction)
  • Reactome Reaction: NET1 → RHOT2 (reaction)
  • Reactome Reaction: RHOV → ITSN1 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF18 (reaction)
  • Reactome Reaction: RAC3 → MCF2L (reaction)
  • Reactome Reaction: ARHGEF16 → RHOJ (reaction)
  • Reactome Reaction: RHOQ → ECT2 (reaction)
  • Reactome Reaction: RHOBTB1 → ARHGEF3 (reaction)
  • Reactome Reaction: ARHGEF11 → CDC42 (reaction)
  • Reactome Reaction: ARHGAP4 → RHOJ (reaction)
  • Reactome Reaction: VAV2 → RHOU (reaction)
  • Reactome Reaction: RHOU → TRIO (reaction)
  • Reactome Reaction: RAC3 → ARHGEF2 (reaction)
  • Reactome Reaction: RHOG → TIAM2 (reaction)
  • Reactome Reaction: RHOH → VAV1 (reaction)
  • Reactome Reaction: SOS2 → CDC42 (reaction)
  • Reactome Reaction: RHOQ → SOS2 (reaction)
  • Reactome Reaction: RHOD → VAV2 (reaction)
  • Reactome Reaction: RHOJ → ARHGEF3 (reaction)
  • Reactome Reaction: ECT2 → RHOT2 (reaction)
  • Reactome Reaction: RHOC → TIAM1 (reaction)
  • Reactome Reaction: RAC3 → RASGRF2 (reaction)
  • Reactome Reaction: RHOU → FGD2 (reaction)
  • Reactome Reaction: RHOA → ARHGEF16 (reaction)
  • Reactome Reaction: RHOQ → FGD3 (reaction)
  • Reactome Reaction: RHOB → FGD4 (reaction)
  • Reactome Reaction: RHOBTB1 → ITSN1 (reaction)
  • Reactome Reaction: RHOBTB2 → FGD2 (reaction)
  • Reactome Reaction: ARHGEF2 → CDC42 (reaction)
  • Reactome Reaction: ARHGEF9 → RHOT1 (reaction)
  • Reactome Reaction: ARHGEF9 → CDC42 (reaction)
  • Reactome Reaction: VAV2 → RHOV (reaction)
  • Reactome Reaction: RHOG → ARHGEF7 (reaction)
  • Reactome Reaction: RHOH → ITSN1 (reaction)
  • Reactome Reaction: RASGRF2 → RHOT1 (reaction)
  • Reactome Reaction: RHOC → ARHGEF17 (reaction)
  • Reactome Reaction: FGD2 → RHOT1 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF11 (reaction)
  • Reactome Reaction: RHOH → FGD3 (reaction)
  • Reactome Reaction: RASGRF2 → RHOV (reaction)
  • Reactome Reaction: RHOD → ARHGAP4 (reaction)
  • Reactome Reaction: RHOG → ABR (reaction)
  • Reactome Reaction: RHOA → TIAM2 (reaction)
  • Reactome Reaction: RHOC → ARHGEF16 (reaction)
  • Reactome Reaction: PLEKHG2 → RHOT2 (reaction)
  • Reactome Reaction: RHOJ → VAV3 (reaction)
  • Reactome Reaction: RAC2 → MCF2 (reaction)
  • Reactome Reaction: RHOH → MCF2 (reaction)
  • Reactome Reaction: FGD1 → RHOC (reaction)
  • Reactome Reaction: RHOU → VAV3 (reaction)
  • Reactome Reaction: RAC3 → TIAM1 (reaction)
  • Reactome Reaction: PLEKHG5 → RHOJ (reaction)
  • Reactome Reaction: RHOA → ARHGAP4 (reaction)
  • Reactome Reaction: RHOBTB1 → TIAM2 (reaction)
  • Reactome Reaction: RHOBTB1 → AKAP13 (reaction)
  • Reactome Reaction: RASGRF2 → RHOU (reaction)
  • Reactome Reaction: CDC42 → VAV3 (reaction)
  • Reactome Reaction: RHOA → MCF2L (reaction)
  • Reactome Reaction: RHOV → FGD2 (reaction)
  • Reactome Reaction: SOS1 → RHOJ (reaction)
  • Reactome Reaction: RHOU → ARHGEF16 (reaction)
  • Reactome Reaction: RAC3 → SOS2 (reaction)
  • Reactome Reaction: RHOBTB1 → FGD3 (reaction)
  • Reactome Reaction: RHOQ → ARHGEF3 (reaction)
  • Reactome Reaction: RHOU → MCF2 (reaction)
  • Reactome Reaction: OBSCN → RHOT2 (reaction)
  • Reactome Reaction: ARHGEF17 → RHOV (reaction)
  • Reactome Reaction: RHOD → ARHGEF17 (reaction)
  • Reactome Reaction: RHOB → ARHGEF18 (reaction)
  • Reactome Reaction: RHOH → ARHGAP4 (reaction)
  • Reactome Reaction: RHOT1 → FGD4 (reaction)
  • Reactome Reaction: RHOBTB2 → NET1 (reaction)
  • Reactome Reaction: RAC2 → FGD4 (reaction)
  • Reactome Reaction: RHOH → TRIO (reaction)
  • Reactome Reaction: RHOH → ARHGEF2 (reaction)
  • Reactome Reaction: RHOH → TIAM1 (reaction)
  • Reactome Reaction: RAC3 → TIAM2 (reaction)
  • Reactome Reaction: VAV1 → RHOU (reaction)
  • Reactome Reaction: RHOA → ARHGEF17 (reaction)
  • Reactome Reaction: RHOG → ARHGEF11 (reaction)
  • Reactome Reaction: SOS2 → RHOT2 (reaction)
  • Reactome Reaction: RHOBTB2 → MCF2L (reaction)
  • Reactome Reaction: TIAM1 → RHOV (reaction)
  • Reactome Reaction: ABR → RHOT1 (reaction)
  • Reactome Reaction: RAC2 → ARHGEF9 (reaction)
  • Reactome Reaction: RHOC → AKAP13 (reaction)
  • Reactome Reaction: RHOA → ARHGEF18 (reaction)
  • Reactome Reaction: RHOD → FGD4 (reaction)
  • Reactome Reaction: RAC3 → MCF2 (reaction)
  • Reactome Reaction: ARHGEF9 → RHOV (reaction)
  • Reactome Reaction: FGD1 → RHOF (reaction)
  • Reactome Reaction: RHOG → ARHGAP4 (reaction)
  • Reactome Reaction: RHOA → FGD3 (reaction)
  • Reactome Reaction: RAC3 → ARHGEF9 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOBTB2 (reaction)
  • Reactome Reaction: RHOB → PLEKHG5 (reaction)
  • Reactome Reaction: ARHGEF17 → RHOT1 (reaction)
  • Reactome Reaction: RHOH → AKAP13 (reaction)
  • Reactome Reaction: ARHGEF18 → RHOJ (reaction)
  • Reactome Reaction: RHOG → ARHGEF17 (reaction)
  • Reactome Reaction: MCF2L → RHOT2 (reaction)
  • Reactome Reaction: RHOH → ARHGEF3 (reaction)
  • Reactome Reaction: ARHGEF6 → RHOA (reaction)
  • Reactome Reaction: RHOBTB2 → RASGRF2 (reaction)
  • Reactome Reaction: RAC2 → SOS2 (reaction)
  • Reactome Reaction: RHOC → SOS1 (reaction)
  • Reactome Reaction: RHOA → ARHGEF4 (reaction)
  • Reactome Reaction: RHOBTB2 → ARHGEF17 (reaction)
  • Reactome Reaction: RHOT2 → ARHGEF12 (reaction)
  • Reactome Reaction: RHOQ → TIAM2 (reaction)
  • Reactome Reaction: CDC42 → FGD3 (reaction)
  • Reactome Reaction: RHOV → KALRN (reaction)
  • Reactome Reaction: RHOBTB2 → AKAP13 (reaction)
  • Reactome Reaction: FGD2 → RHOJ (reaction)
  • Reactome Reaction: RAC3 → VAV1 (reaction)
  • Reactome Reaction: RHOBTB1 → TIAM1 (reaction)
  • Reactome Reaction: SOS1 → CDC42 (reaction)
  • Reactome Reaction: RAC2 → VAV2 (reaction)
  • Reactome Reaction: RHOT2 → ARHGEF3 (reaction)
  • Reactome Reaction: RAC2 → ARHGEF17 (reaction)
  • Reactome Reaction: RHOQ → ARHGEF18 (reaction)
  • Reactome Reaction: RHOG → TRIO (reaction)
  • Reactome Reaction: RHOQ → VAV3 (reaction)
  • Reactome Reaction: MCF2L → RHOV (reaction)
  • Reactome Reaction: OBSCN → RHOJ (reaction)
  • Reactome Reaction: RHOC → FGD4 (reaction)
  • Reactome Reaction: RHOQ → AKAP13 (reaction)
  • Reactome Reaction: RAC3 → FGD4 (reaction)
  • Reactome Reaction: ARHGAP4 → CDC42 (reaction)
  • Reactome Reaction: FGD1 → RHOV (reaction)
  • Reactome Reaction: ITSN1 → RHOJ (reaction)
  • Reactome Reaction: RAC3 → VAV2 (reaction)
  • Reactome Reaction: RHOV → NGEF (reaction)
  • Reactome Reaction: RHOQ → NGEF (reaction)
  • Reactome Reaction: ARHGEF6 → RHOBTB1 (reaction)
In total, 666 gene pairs are associated to this article in curated databases