Eur J Biochem 1995,
PMID: 7705335
Ko, J L; Hsu, C I; Lin, R H; Kao, C L; Lin, J Y
A new fungal immunomodulatory protein (FIP-fve) has been isolated and purified from the edible golden needle mushroom (Flammulina velutipes). The apparent molecular mass of FIP-fve determined by SDS/PAGE agrees well with the value of 12704 Da calculated from its amino acid composition and sequence. The complete amino acid sequence of FIP-fve was elucidated by protein sequencing techniques. FIP-fve consists of 114 amino acid residues with an acetylated amino end, and lacks methionine, half-cystine and histidine residues. FIP-fve was able to hemagglutinate human red blood cells. The immunomodulatory activity of FIP-fve was demonstrated by its stimulatory activity toward human peripheral blood lymphocytes, and its suppression of systemic anaphylaxis reactions and local swelling of mouse footpads. FIP-fve was found to enhance the transcriptional expression of interleukin-2 and interferon-gamma.
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Text Mining Data
interferon-gamma → FIP-fve: "
FIP-fve was found to
enhance the transcriptional expression of interleukin-2 and
interferon-gamma
"
interleukin-2 → FIP-fve: "
FIP-fve was found to enhance the transcriptional expression of interleukin-2 and interferon-gamma
"
Manually curated Databases
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