Cell Mol Immunol 2008,
PMID: 18318992
Gu, Tao; Zhu, Yi Bei; Chen, Cheng; Li, Min; Chen, Yong Jing; Yu, Ge Hua; Ge, Yan; Zhou, Shi Yong; Zhou, Huan; Huang, Yong; Qiu, Yu Hua; Zhang, Xue Guang
During maturation, murine myeloid dendritic cells (DCs) upregulated the expressions of CD11c, CD25, CD40, CD80, CD86, MHC II and programmed death 1 ligands 1 and 2 (PD-L1 and PD-L2). Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-alpha. PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40-ligated DCs, whereas TNF-alpha stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs. Proliferations of T lymphocytes stimulated by immature DCs were enhanced by blockade of the PD-1 and PD-1 ligand interaction. But inhibitive effects were found in T lymphocytes stimulated by CD40-ligated DCs. With the fine-tuned expressions of PD-L1 and PD-L2, CD40-ligated DCs could sustain a longer activation period and elicit a more efficient T lymphocyte activation.
Diseases/Pathways annotated by Medline MESH: Neoplasms
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Text Mining Data
DCs → TNF-alpha: "
Differential expression patterns of PD-L1 and PD-L2 were found when
DCs were
triggered by CD40 ligand and
TNF-alpha
"
DCs → CD40 ligand: "
Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-alpha
"
DCs → TNF-alpha: "
PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs, whereas TNF-alpha stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs
"
PD-L2 → TNF-alpha: "
PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs, whereas TNF-alpha stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs
"
Manually curated Databases
No curated data.