J Neuroimmunol 2004,
PMID: 15265671
Zhao, Meng-Liang; Brosnan, Celia F; Lee, Sunhee C
We studied the role of 15-deoxy-delta (12,14)-PGJ2 (15d-PGJ2), a macrophage inhibitor with reported therapeutic effects on experimental allergic encephalomyelitis, in human astrocyte activation in vitro. 15d-PGJ2 inhibited a broad range of astrocyte inflammatory gene expression induced by IL-1, including cytokines (TNFalpha and IL-6), chemokines (RANTES/CCL5 and IP-10/CXCL10) and inducible nitric oxide synthase. 15d-PGJ2 inhibited transactivation of NF-kappaB-dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN-induced Stat signaling pathways. Our results demonstrating 15d-PGJ2-mediated astrocyte deactivation through inhibition of NF-kappaB are similar to those described for macrophages, and add astrocytes as additional targets for this prostaglandin (PG).
Diseases/Pathways annotated by Medline MESH: MAP Kinase Signaling System
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Text Mining Data
p38 → IL-1: "
15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as
p38 and JNK MAPK phosphorylation
induced by
IL-1 , while having no inhibitory effect on IFN induced Stat signaling pathways
"
p38 → NF-kappaB: "
15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN induced Stat signaling pathways
"
MAPK → IL-1: "
15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1 , while having no inhibitory effect on IFN induced Stat signaling pathways
"
MAPK → NF-kappaB: "
15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN induced Stat signaling pathways
"
Manually curated Databases
No curated data.