Gene interactions and pathways from curated databases and text-mining
J Neuroimmunol 2004, PMID: 15265671

15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression.

Zhao, Meng-Liang; Brosnan, Celia F; Lee, Sunhee C

We studied the role of 15-deoxy-delta (12,14)-PGJ2 (15d-PGJ2), a macrophage inhibitor with reported therapeutic effects on experimental allergic encephalomyelitis, in human astrocyte activation in vitro. 15d-PGJ2 inhibited a broad range of astrocyte inflammatory gene expression induced by IL-1, including cytokines (TNFalpha and IL-6), chemokines (RANTES/CCL5 and IP-10/CXCL10) and inducible nitric oxide synthase. 15d-PGJ2 inhibited transactivation of NF-kappaB-dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN-induced Stat signaling pathways. Our results demonstrating 15d-PGJ2-mediated astrocyte deactivation through inhibition of NF-kappaB are similar to those described for macrophages, and add astrocytes as additional targets for this prostaglandin (PG).

Diseases/Pathways annotated by Medline MESH: MAP Kinase Signaling System
Document information provided by NCBI PubMed

Text Mining Data

p38 → IL-1: " 15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1 , while having no inhibitory effect on IFN induced Stat signaling pathways "

p38 → NF-kappaB: " 15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN induced Stat signaling pathways "

MAPK → IL-1: " 15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1 , while having no inhibitory effect on IFN induced Stat signaling pathways "

MAPK → NF-kappaB: " 15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN induced Stat signaling pathways "

Manually curated Databases

No curated data.