Gene interactions and pathways from curated databases and text-mining
Biochem Biophys Res Commun 2003, PMID: 12901880

BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

Qin, Wenxin; Hu, Jian; Guo, Minglei; Xu, Jian; Li, Jinjun; Yao, Genfu; Zhou, Xiaomei; Jiang, Huiqiu; Zhang, Pingping; Shen, Li; Wan, Dafang; Gu, Jianren

The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. Little is known about the mechanisms underlying this process. We report here the identification of a novel member of BNIPL family, designated Bcl-2/adenovirus E1B 19kDa interacting protein 2 like-2 (BNIPL-2), which interacts with Bcl-2 and Cdc42GAP. We found that the human BNIPL-2 shares homology to human BNIP-2 and also possesses a BNIP-2 and Cdc42GAP homology (BCH) domain. Deletion experiments indicated that the BCH domain of BNIPL-2 is critical for its interactions with the Bcl-2 and Cdc42GAP and also for its cell death-inducing function. Our data showed that BNIPL-2 may be a linker protein located at the front end of Bcl-2 pathway for DNA fragmentation and Cdc42 signaling for morphological changes during apoptosis. We propose that BNIPL-2 protein may play an important role in regulation of both pathways for DNA fragmentation and for formation of membrane blebs in apoptotic cells.

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Text Mining Data

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Manually curated Databases

  • IRef Bind Interaction: BNIPL — BNIPL
  • IRef Bind Interaction: ARHGAP1 — BNIPL
  • IRef Bind_translation Interaction: BCL2 — BNIPL (affinity chromatography technology)
  • IRef Bind_translation Interaction: BCL2 — BNIPL (two hybrid)
  • IRef Bind_translation Interaction: BNIPL — BNIPL (two hybrid)
  • IRef Bind_translation Interaction: BNIPL — BNIPL (affinity chromatography technology)
  • IRef Bind_translation Interaction: ARHGAP1 — BNIPL (affinity chromatography technology)
  • IRef Bind_translation Interaction: ARHGAP1 — BNIPL (two hybrid)
  • IRef Bind_translation Interaction: ARHGAP1 — BNIPL (experimental interaction detection)
  • IRef Biogrid Interaction: BNIPL — BNIP2 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: BCL2 — BNIPL (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: BCL2 — BNIPL (direct interaction, two hybrid)
  • IRef Biogrid Interaction: BNIPL — BAX (direct interaction, two hybrid)
  • IRef Biogrid Interaction: BNIPL — BNIPL (direct interaction, two hybrid)
  • IRef Biogrid Interaction: BNIPL — BNIPL (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: BCL2 — BNIP2 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: BNIPL — CDC42 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: BNIPL — CDC42 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ARHGAP1 — BNIPL (direct interaction, two hybrid)
  • IRef Biogrid Interaction: BNIPL — BCL2L1 (direct interaction, two hybrid)
  • IRef Hprd Interaction: BNIPL — BNIP2 (two hybrid)
  • IRef Hprd Interaction: BCL2 — BNIPL (two hybrid)
  • IRef Hprd Interaction: BCL2 — BNIPL (in vitro)
  • IRef Hprd Interaction: BNIPL — BNIPL (in vitro)
  • IRef Hprd Interaction: BNIPL — BNIPL (two hybrid)
  • IRef Hprd Interaction: BCL2 — BNIP2 (two hybrid)
  • IRef Hprd Interaction: BCL2 — BNIP2 (in vitro)
  • IRef Hprd Interaction: BNIPL — ARHGAP1 (in vitro)
  • IRef Hprd Interaction: BNIPL — ARHGAP1 (two hybrid)
In total, 8 gene pairs are associated to this article in curated databases