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CD40 → IFN-gamma: " We have previously shown that IFN-gamma induces CD40 expression in macrophages and microglia "
STAT-1alpha → IFN-gamma: " IFN-gamma leads to STAT-1alpha activation directly and up-regulation of NF-kappaB activity due to the secretion and subsequent autocrine signaling of TNF-alpha "
NF-kappaB → IFN-gamma: " IFN-gamma leads to STAT-1alpha activation directly and up-regulation of NF-kappaB activity due to the secretion and subsequent autocrine signaling of TNF-alpha "
CD40 → IFN-gamma: " We show that ectopic expression of SOCS-1 abrogates IFN-gamma induced CD40 protein expression, mRNA levels, and promoter activity "
STAT-1alpha ⊣ SOCS-1: " Additionally, IFN-gamma induced TNF-alpha secretion, as well as STAT-1alpha and NF-kappaB activation, are inhibited in the presence of SOCS-1 "
TNF-alpha ⊣ SOCS-1: " Additionally, IFN-gamma induced TNF-alpha secretion, as well as STAT-1alpha and NF-kappaB activation, are inhibited in the presence of SOCS-1 "
NF-kappaB ⊣ SOCS-1: " Additionally, IFN-gamma induced TNF-alpha secretion, as well as STAT-1alpha and NF-kappaB activation, are inhibited in the presence of SOCS-1 "
STAT-1alpha → IFN-gamma: " Additionally, IFN-gamma induced TNF-alpha secretion, as well as STAT-1alpha and NF-kappaB activation, are inhibited in the presence of SOCS-1 "
TNF-alpha → IFN-gamma: " Additionally, IFN-gamma induced TNF-alpha secretion, as well as STAT-1alpha and NF-kappaB activation, are inhibited in the presence of SOCS-1 "
NF-kappaB → IFN-gamma: " Additionally, IFN-gamma induced TNF-alpha secretion, as well as STAT-1alpha and NF-kappaB activation , are inhibited in the presence of SOCS-1 "
CD40 ⊣ SOCS-1: " We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation "
STAT-1alpha → IFN-gamma: " We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation "
TNF-alpha → IFN-gamma: " We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation "
CD40 → STAT-1alpha: " We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation "
CD40 → IFN-gamma: " We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation "
NF-kappaB → TNF-alpha: " We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation "