Dev Cell 2002,
PMID: 11832245
Rappleye, Chad A; Tagawa, Akiko; Lyczak, Rebecca; Bowerman, Bruce; Aroian, Raffi V
Polarization of the one-cell C. elegans embryo establishes the animal's anterior-posterior (a-p) axis. We have identified reduction-of-function anaphase-promoting complex (APC) mutations that eliminate a-p polarity. We also demonstrate that the APC activator cdc20 is required for polarity. The APC excludes PAR-3 from the posterior cortex, allowing PAR-2 to accumulate there. The APC is also required for tight cortical association and posterior movement of the paternal pronucleus and its associated centrosome. Depletion of the protease separin, a downstream target of the APC, causes similar pronuclear and a-p polarity defects. We propose that the APC/separin pathway promotes close association of the centrosome with the cortex, which in turn excludes PAR-3 from the posterior pole early in a-p axis formation.
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Text Mining Data
centrosome → APC: "
The
APC is also
required for tight cortical association and posterior movement of the paternal pronucleus and its associated
centrosome
"
Manually curated Databases
No curated data.