Arch Dermatol Res 2000,
PMID: 10929773
Yamaoka, J; Sasaki, M; Miyachi, Y
Ultraviolet radiation causes inflammation characterized by erythema and swelling, but also exhibits antiinflammatory effects which have led to the use of ultraviolet B radiation (UVBR) and psoralen plus ultraviolet A (PUVA) in the treatment of psoriasis, chronic severe atopic dermatitis and uremic pruritus. In inflammatory dermatoses, a pathogenic role of nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) has been suggested. To elucidate how UVBR regulates iNOS expression in skin under inflammatory conditions, we investigated the effect of UVBR on NO production and iNOS expression in cultured murine keratinocyte Pam 212 cells stimulated with interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha). Low doses of UVBR significantly suppressed IFN-gamma- or TNF-alpha-induced NO production. UVBR also downregulated IFN-gamma- or TNF-alpha-induced iNOS expression at both the mRNA level and the protein level. These findings suggest the possibility that the down-regulatory effect of UVBR on IFN-gamma- or TNF-alpha-induced iNOS expression may, in part, explain the antiinflammatory and therapeutic properties of UVBR in inflammatory dermatoses.
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Text Mining Data
nitric oxide synthase → tumor necrosis factor-alpha: "
Ultraviolet B radiation downregulates inducible
nitric oxide synthase expression
induced by interferon-gamma or
tumor necrosis factor-alpha in murine keratinocyte Pam 212 cells
"
nitric oxide synthase → interferon-gamma: "
Ultraviolet B radiation downregulates inducible nitric oxide synthase expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocyte Pam 212 cells
"
iNOS → TNF-alpha: "
UVBR also downregulated IFN-gamma- or TNF-alpha induced iNOS expression at both the mRNA level and the protein level
"
iNOS → TNF-alpha: "
These findings suggest the possibility that the down-regulatory effect of UVBR on IFN-gamma- or TNF-alpha induced iNOS expression may, in part, explain the antiinflammatory and therapeutic properties of UVBR in inflammatory dermatoses
"
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