ID:PCIF1_HUMAN DESCRIPTION: RecName: Full=Phosphorylated CTD-interacting factor 1; FUNCTION: May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit. SUBUNIT: Interacts with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit. SIMILARITY: Contains 1 WW domain.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PCIF1 CDC HuGE Published Literature: PCIF1 Positive Disease Associations: Cholesterol, HDL
, Triglycerides Related Studies:
Cholesterol, HDL Sekar Kathiresan et al. Nature genetics 2009, Common variants at 30 loci contribute to polygenic dyslipidemia., Nature genetics.
[PubMed 19060906]
Triglycerides Sekar Kathiresan et al. Nature genetics 2009, Common variants at 30 loci contribute to polygenic dyslipidemia., Nature genetics.
[PubMed 19060906]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H4Z3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
