Human Gene ING5 (uc002wcd.3) Description and Page Index
  Description: Homo sapiens inhibitor of growth family, member 5 (ING5), mRNA.
RefSeq Summary (NM_032329): This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.33000.1, AK074422.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr2:242,641,456-242,668,896 Size: 27,441 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr2:242,641,481-242,664,446 Size: 22,966 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:242,641,456-242,668,896)mRNA (may differ from genome)Protein (240 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Inhibitor of growth protein 5; AltName: Full=p28ING5;
FUNCTION: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.
SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with EP300 and TP53.
DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3.
SIMILARITY: Belongs to the ING family.
SIMILARITY: Contains 1 PHD-type zinc finger.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ING5
CDC HuGE Published Literature: ING5

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.56 RPKM in Brain - Cerebellum
Total median expression: 323.34 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.9025-0.196 Picture PostScript Text
3' UTR -1814.504450-0.408 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024610 - ING_N
IPR019786 - Zinc_finger_PHD-type_CS
IPR011011 - Znf_FYVE_PHD
IPR001965 - Znf_PHD
IPR019787 - Znf_PHD-finger

Pfam Domains:
PF12998 - Inhibitor of growth proteins N-terminal histone-binding

SCOP Domains:
57903 - FYVE/PHD zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q8WYH8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0035064 methylated histone binding
GO:0046872 metal ion binding

Biological Process:
GO:0006260 DNA replication
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006473 protein acetylation
GO:0008285 negative regulation of cell proliferation
GO:0016573 histone acetylation
GO:0043065 positive regulation of apoptotic process
GO:0043966 histone H3 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045926 negative regulation of growth
GO:1901796 regulation of signal transduction by p53 class mediator

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070776 MOZ/MORF histone acetyltransferase complex

-  Descriptions from all associated GenBank mRNAs
  AK289958 - Homo sapiens cDNA FLJ78184 complete cds, highly similar to Homo sapiens inhibitor of growth family, member 5 (ING5), mRNA.
AK074422 - Homo sapiens cDNA FLJ23842 fis, clone KAT05909.
AK300790 - Homo sapiens cDNA FLJ53592 complete cds, highly similar to Inhibitor of growth protein 5.
BC005370 - Homo sapiens inhibitor of growth family, member 5, mRNA (cDNA clone MGC:12485 IMAGE:3932127), complete cds.
BC071899 - Homo sapiens inhibitor of growth family, member 5, mRNA (cDNA clone MGC:88578 IMAGE:6111003), complete cds.
AF189286 - Homo sapiens p28 ING5 mRNA, complete cds.
KJ903408 - Synthetic construct Homo sapiens clone ccsbBroadEn_12802 ING5 gene, encodes complete protein.
KJ894965 - Synthetic construct Homo sapiens clone ccsbBroadEn_04359 ING5 gene, encodes complete protein.
CU675145 - Synthetic construct Homo sapiens gateway clone IMAGE:100016818 5' read ING5 mRNA.
CU687190 - Synthetic construct Homo sapiens gateway clone IMAGE:100023105 5' read ING5 mRNA.
AB527747 - Synthetic construct DNA, clone: pF1KB7940, Homo sapiens ING5 gene for inhibitor of growth family, member 5, without stop codon, in Flexi system.
EU832330 - Synthetic construct Homo sapiens clone HAIB:100067359; DKFZo008F0427 similar to p28 ING5 protein (LOC727773) gene, encodes complete protein.
EU832415 - Synthetic construct Homo sapiens clone HAIB:100067444; DKFZo004F0428 similar to p28 ING5 protein (LOC727773) gene, encodes complete protein.
HQ447553 - Synthetic construct Homo sapiens clone IMAGE:100070892; CCSB014979_01 inhibitor of growth family, member 5 (ING5) gene, encodes complete protein.
AY203944 - Homo sapiens LP5553 mRNA, complete cds.
JD478327 - Sequence 459351 from Patent EP1572962.
JD479761 - Sequence 460785 from Patent EP1572962.
JD024750 - Sequence 5774 from Patent EP1572962.
JD034843 - Sequence 15867 from Patent EP1572962.
JD462668 - Sequence 443692 from Patent EP1572962.
JD210661 - Sequence 191685 from Patent EP1572962.
JD560055 - Sequence 541079 from Patent EP1572962.
JD332504 - Sequence 313528 from Patent EP1572962.
JD056629 - Sequence 37653 from Patent EP1572962.
JD114661 - Sequence 95685 from Patent EP1572962.
AK128322 - Homo sapiens cDNA FLJ46463 fis, clone THYMU3021900.
JD160799 - Sequence 141823 from Patent EP1572962.
JD281432 - Sequence 262456 from Patent EP1572962.
JD281433 - Sequence 262457 from Patent EP1572962.
JD492026 - Sequence 473050 from Patent EP1572962.
JD492027 - Sequence 473051 from Patent EP1572962.
JD321244 - Sequence 302268 from Patent EP1572962.
JD388812 - Sequence 369836 from Patent EP1572962.
JD457397 - Sequence 438421 from Patent EP1572962.
JD388813 - Sequence 369837 from Patent EP1572962.
JD388814 - Sequence 369838 from Patent EP1572962.
JD457398 - Sequence 438422 from Patent EP1572962.
JD457399 - Sequence 438423 from Patent EP1572962.
JD513378 - Sequence 494402 from Patent EP1572962.
JD435463 - Sequence 416487 from Patent EP1572962.
JD308169 - Sequence 289193 from Patent EP1572962.
JD254764 - Sequence 235788 from Patent EP1572962.
BC039028 - Homo sapiens inhibitor of growth family, member 5, mRNA (cDNA clone IMAGE:4525110), partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WYH8 (Reactome details) participates in the following event(s):

R-HSA-6805620 KAT6A and PML bind TP53
R-HSA-6805640 AKT phosphorylates KAT6A
R-HSA-3318486 KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3
R-HSA-6805638 KAT6A acetylates TP53
R-HSA-6805650 MTA2-NuRD complex deacetylates TP53
R-HSA-3318413 KAT7-containing ING4/5 complexes acetylate Me3K-histone H3
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-3214847 HATs acetylate histones
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-4839726 Chromatin organization
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1P3, ING5_HUMAN, NM_032329, NP_115705, Q53NU6, Q57Z54, Q8WYH8, Q9BS30
UCSC ID: uc002wcd.3
RefSeq Accession: NM_032329
Protein: Q8WYH8 (aka ING5_HUMAN)
CCDS: CCDS33425.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_032329.4
exon count: 8CDS single in 3' UTR: no RNA size: 5233
ORF size: 723CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1436.00frame shift in genome: no % Coverage: 99.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.