Human Gene EIF4G3 (uc001bef.3) Description and Page Index
  Description: Homo sapiens eukaryotic translation initiation factor 4 gamma, 3 (EIF4G3), transcript variant 1, mRNA.
RefSeq Summary (NM_001198801): The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016].
Transcript (Including UTRs)
   Position: hg19 chr1:21,132,785-21,503,381 Size: 370,597 Total Exon Count: 35 Strand: -
Coding Region
   Position: hg19 chr1:21,133,812-21,329,235 Size: 195,424 Coding Exon Count: 31 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:21,132,785-21,503,381)mRNA (may differ from genome)Protein (1621 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
ReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): EIF4G3
CDC HuGE Published Literature: EIF4G3
Positive Disease Associations: Body Weights and Measures , Creatinine , Fibrinogen
Related Studies:
  1. Body Weights and Measures
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  2. Creatinine
    Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics. [PubMed 17903292]
    Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
  3. Fibrinogen
    Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903294]
    Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.17 RPKM in Testis
Total median expression: 592.78 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -246.45622-0.396 Picture PostScript Text
3' UTR -233.241027-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF02020 - eIF4-gamma/eIF5/eIF2-epsilon
PF02847 - MA3 domain
PF02854 - MIF4G domain

SCOP Domains:
48371 - ARM repeat
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on O43432-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AF012072 - Homo sapiens eIF4GII mRNA, complete cds.
AB209119 - Homo sapiens mRNA for eukaryotic translation initiation factor 4 gamma, 3 variant protein.
BC094683 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:102792 IMAGE:6188273), complete cds.
BC072413 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:6165611), partial cds.
BC136643 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:168256 IMAGE:9020633), complete cds.
BC144335 - Homo sapiens cDNA clone IMAGE:9052855, containing frame-shift errors.
AK294883 - Homo sapiens cDNA FLJ59298 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
AK225489 - Homo sapiens mRNA for Splice isoform 2 of O43432 variant, clone: JTH03575.
BC030578 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:4836870), complete cds.
AK302087 - Homo sapiens cDNA FLJ60945 complete cds, highly similar to Eukaryotic translation initiation factor 4gamma 3.
JD558073 - Sequence 539097 from Patent EP1572962.
AK302873 - Homo sapiens cDNA FLJ53944 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
JD261059 - Sequence 242083 from Patent EP1572962.
JD164334 - Sequence 145358 from Patent EP1572962.
Z34918 - H.sapiens mRNA for translation initiation factor eIF-4gamma (partial).
JD102602 - Sequence 83626 from Patent EP1572962.
AK310195 - Homo sapiens cDNA, FLJ17237.
BX647897 - Homo sapiens mRNA; cDNA DKFZp686C17112 (from clone DKFZp686C17112).
JD244587 - Sequence 225611 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05416 - Viral myocarditis

BioCarta from NCI Cancer Genome Anatomy Project
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_eifPathway - Eukaryotic protein translation
h_mTORPathway - mTOR Signaling Pathway
h_iresPathway - Internal Ribosome entry pathway

Reactome (by CSHL, EBI, and GO)

Protein O43432 (Reactome details) participates in the following event(s):

R-HSA-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001198801, NP_001185730, O43432-3
UCSC ID: uc001bef.3
RefSeq Accession: NM_001198801
Protein: O43432-3 CCDS: CCDS214.1, CCDS55580.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001198801.1
exon count: 35CDS single in 3' UTR: no RNA size: 6515
ORF size: 4866CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 9132.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.