Human Gene SEC23A (ENST00000548032.6) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt G3V1W4)
RefSeq Summary (NM_006364): The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036649.1, SRR1803614.13931.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307712.11/ ENSP00000306881.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000548032.6
Gencode Gene: ENSG00000100934.15
Transcript (Including UTRs)
   Position: hg38 chr14:39,092,761-39,103,212 Size: 10,452 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr14:39,093,139-39,096,118 Size: 2,980 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:39,092,761-39,103,212)mRNA (may differ from genome)Protein (108 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: G3V1W4_HUMAN
DESCRIPTION: SubName: Full=Protein transport protein Sec23A;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: SEC23A
Diseases sorted by gene-association score: craniolenticulosutural dysplasia* (1678), cole-carpenter syndrome (10), congenital dyserythropoietic anemia (8)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.54 RPKM in Cells - Transformed fibroblasts
Total median expression: 555.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.20202-0.427 Picture PostScript Text
3' UTR -108.80378-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006895 - Znf_Sec23_Sec24

Pfam Domains:
PF04810 - Sec23/Sec24 zinc finger

ModBase Predicted Comparative 3D Structure on G3V1W4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport

Cellular Component:
GO:0030127 COPII vesicle coat


-  Descriptions from all associated GenBank mRNAs
  BC036649 - Homo sapiens Sec23 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:26267 IMAGE:4821858), complete cds.
LF384850 - JP 2014500723-A/192353: Polycomb-Associated Non-Coding RNAs.
MA620427 - JP 2018138019-A/192353: Polycomb-Associated Non-Coding RNAs.
AK293944 - Homo sapiens cDNA FLJ55960 complete cds, highly similar to Protein transport protein Sec23A.
AK299862 - Homo sapiens cDNA FLJ53608 complete cds, highly similar to Protein transport protein Sec23A.
X97064 - H.sapiens mRNA for Sec23A isoform, 2748bp.
AK312259 - Homo sapiens cDNA, FLJ92554, Homo sapiens Sec23 homolog A (S. cerevisiae) (SEC23A), mRNA.
DQ890902 - Synthetic construct clone IMAGE:100003532; FLH166937.01X; RZPDo839F0388D Sec23 homolog A (S. cerevisiae) (SEC23A) gene, encodes complete protein.
DQ893347 - Synthetic construct clone IMAGE:100005977; FLH196473.01X; RZPDo839D10156D Sec23 homolog A (S. cerevisiae) (SEC23A) gene, encodes complete protein.
DQ894055 - Synthetic construct Homo sapiens clone IMAGE:100008515; FLH166936.01L; RZPDo839F0387D Sec23 homolog A (S. cerevisiae) (SEC23A) gene, encodes complete protein.
AK303485 - Homo sapiens cDNA FLJ52821 complete cds, highly similar to Protein transport protein Sec23A.
LF329362 - JP 2014500723-A/136865: Polycomb-Associated Non-Coding RNAs.
MA564939 - JP 2018138019-A/136865: Polycomb-Associated Non-Coding RNAs.
JD216842 - Sequence 197866 from Patent EP1572962.
JD317185 - Sequence 298209 from Patent EP1572962.
JD141489 - Sequence 122513 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK299862, G3V1W4, G3V1W4_HUMAN, uc059azp.1
UCSC ID: uc059azp.1
RefSeq Accession: NM_006364
Protein: G3V1W4

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.