Human Gene MTOR (ENST00000376838.5) from GENCODE V44
|
|
Sequence and Links to Tools and Databases
|
|
Primer design for this transcript
|
|
MalaCards Disease Associations
|
|
MalaCards Gene Search: MTOR
Diseases sorted by gene-association score: smith-kingsmore syndrome* (1580), focal cortical dysplasia, type ii, somatic* (1550), glioblastoma multiforme (24), luminal breast carcinoma (21), tuberous sclerosis (20), subependymal giant cell astrocytoma (18), atopic dermatitis 5 (18), lymphangioleiomyomatosis (16), kidney cancer (15), angiomyolipoma (15), glioblastoma (14), vulvar seborrheic keratosis (14), pancreatic neuroendocrine tumor (13), lung large cell carcinoma (13), laryngomalacia (12), hepatic angiomyolipoma (12), subependymal glioma (12), benign ependymoma (12), hypoxia (12), muscle hypertrophy (12), autosomal dominant polycystic kidney disease (12), diffuse intrinsic pontine glioma (10), paronychia (10), large intestine adenocarcinoma (10), kidney angiomyolipoma (10), umbilical hernia (9), tracheal cancer (9), ewing's family of tumors (9), ovarian clear cell adenocarcinoma (8), renal clear cell carcinoma (8), dermatosis papulosa nigra (8), alexander disease (8), mucositis (8), lymphocele (8), estrogen-receptor positive breast cancer (7), pyogenic granuloma (7), hemimegalencephaly (7), plasmablastic lymphoma (7), stomatitis (7), inverted follicular keratosis (7), mantle cell lymphoma (6), kaposiform hemangioendothelioma (6), keratosis, seborrheic, somatic (6), cytomegalovirus infection (6), megalencephaly (6), mucolipidosis iv (6), large cell acanthoma (6), focal epilepsy (5), corticobasal degeneration (5), endometrial cancer (5), kidney benign neoplasm (5), clear cell adenofibroma (5), kaposi sarcoma (4), exanthem (4), pancreatic cancer (4), renal cell carcinoma (4), spinal cord ependymoma (3), prostate cancer (3), breast cancer (3), fragile x syndrome (2), autoimmune lymphoproliferative syndrome (2), lung cancer (2), hematologic cancer (2), hepatocellular carcinoma (2), intellectual disability (2), intestinal obstruction (2), ovarian cancer, somatic (1), leigh syndrome (1), leukemia, acute myeloid (0) * = Manually curated disease association
| |
|
|
Comparative Toxicogenomics Database (CTD)
|
|
The following chemicals interact with this gene
- D020123
Sirolimus
- C059514
resveratrol
- C085911
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
- D019256
Cadmium Chloride
- D010712
Phosphatidic Acids
- C401859
temsirolimus
- C516138
(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine
- C070379
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
- C532162
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
- C500530
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide
- D015127
9,10-Dimethyl-1,2-benzanthracene
- C031143
AICA ribonucleotide
- D002994
Clofibrate
- D004317
Doxorubicin
- D004533
Egtazic Acid
- D005947
Glucose
- D008070
Lipopolysaccharides
- D008694
Methamphetamine
- C522973
PI103
- D010269
Paraquat
- D010656
Phenylephrine
- D019821
Simvastatin
- D013629
Tamoxifen
- D013749
Tetrachlorodibenzodioxin
- D014268
Trifluoperazine
- C006632
arsenic trioxide
- C107135
everolimus
- C419708
gefitinib
- C009687
wortmannin
- C028474
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
- C569670
1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
- D020001
1-Butanol
- D015632
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- C097240
15-deoxy-delta(12,14)-prostaglandin J2
- C561454
2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide
- C016403
2,4-dinitrotoluene
- C023514
2,6-dinitrotoluene
- C560905
3-(2-(dimethylamino)isopropoxy)-1-hydroxybenzo(b)naphtho(2,3-d)furan-6,11-dione
- C528740
3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide
- C025946
3-methyladenine
- C027576
4-hydroxy-2-nonenal
- C065250
4-hydroxy-equilenin
- C003001
7-ketocholesterol
- C499693
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one
- C558529
9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one
- D000079
Acetaldehyde
- D000082
Acetaminophen
- D000111
Acetylcysteine
- D000602
Amino Acids, Peptides, and Proteins
- D000638
Amiodarone
- D000643
Ammonium Chloride
- D000735
Androstenedione
- C557045
BO-1051
- D001564
Benzo(a)pyrene
- D001647
Bile Acids and Salts
- D002104
Cadmium
- D002110
Caffeine
- D002118
Calcium
- D002211
Capsaicin
- D002392
Catechin
- D002762
Cholecalciferol
- D002945
Cisplatin
- D003345
Corticosterone
- D003474
Curcumin
- D003630
Daunorubicin
- D003958
Diamide
- D004112
Dimercaprol
- D015232
Dinoprostone
- D004298
Dopamine
- C572014
E platinum
- D004441
Ecdysterone
- D004958
Estradiol
- D000431
Ethanol
- D004997
Ethinyl Estradiol
- D005038
Ethylnitrosourea
- D005473
Fluoxetine
- D006581
Hexachlorobenzene
- D007980
Levodopa
- D008094
Lithium
- C523799
MRK 003
- D008298
Maleates
- D008344
Maneb
- D008345
Manganese
- D008550
Melatonin
- D008774
Methylphenidate
- D008798
Mevalonic Acid
- D015735
Mifepristone
- C512715
NSC-87877
- C502355
NVP ADW742
- D009525
Niacin
- D009536
Niacinamide
- D009534
Niclosamide
- D009569
Nitric Oxide
- C529674
OSU-HDAC42 compound
- D010100
Oxygen
- C544306
PI 540
- D010480
Perhexiline
- D017319
Photosensitizing Agents
- D017035
Pravastatin
- D011794
Quercetin
- D017382
Reactive Oxygen Species
- D012906
Smoke
- D013267
Stilbenes
- D013654
Taurine
- D013739
Testosterone
- D013755
Tetradecanoylphorbol Acetate
- D019772
Topotecan
- D014241
Trichloroethylene
- D014415
Tunicamycin
- D014640
Vancomycin
- C510150
ZSTK474
- C016601
afimoxifene
- C103303
alitretinoin
- C011512
alpha-naphthoflavone
- C558369
antrocin
- C545357
antroquinonol
- C006780
bisphenol A
- C002415
cholesterol alpha-oxide
- C531198
dactolisib
- C488369
dasatinib
- C107676
deguelin
- C400278
erlotinib
- C070081
fulvestrant
- C002963
geranylgeranyl pyrophosphate
- C097613
imatinib
- C067431
letrozole
- C032881
lysophosphatidic acid
- C030110
oxaliplatin
- C029341
oxophenylarsine
- C105905
perifosine
- C006253
pirinixic acid
- C010423
pyrithione zinc
- C089730
rosiglitazone
- C085746
rottlerin
- C471405
sorafenib
- C534735
tetraarsenic tetrasulfide
- C014215
tetrahydropalmatine
- C099150
trabectedin
- C011559
tributyltin
- C015559
trimellitic anhydride
- C101044
tyrphostin AG 1478
- C111237
vorinostat
| |
|
|
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
|
|
Microarray Expression Data
|
|
Press "+" in the title bar above to open this section.
| |
|
|
Orthologous Genes in Other Species
|
|
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
| | | | | |
| | | | | |
| | | | | |
| | | | | |
| | | | | |
|
| |
|
|
Descriptions from all associated GenBank mRNAs
|
|
LP830499 - Sequence 1 from Patent EP3211090. U88966 - Human protein rapamycin associated protein (FRAP2) gene, complete cds. AB209995 - Homo sapiens mRNA for FRAP1 variant protein, clone: ef01094. AK302863 - Homo sapiens cDNA FLJ60991 complete cds, highly similar to FKBP12-rapamycin complex-associated protein. AK304273 - Homo sapiens cDNA FLJ56559 complete cds, highly similar to FKBP12-rapamycin complex-associated protein. BC117166 - Homo sapiens FK506 binding protein 12-rapamycin associated protein 1, mRNA (cDNA clone MGC:150775 IMAGE:40125717), complete cds. L34075 - Human FKBP-rapamycin associated protein (FRAP) mRNA, complete cds. AB384693 - Synthetic construct DNA, clone: pF1KB1123, Homo sapiens FRAP1 gene for FKBP12-rapamycin complex-associated protein, complete cds, without stop codon, in Flexi system. AK126762 - Homo sapiens cDNA FLJ44809 fis, clone BRACE3044172, highly similar to FKBP12-rapamycin complex-associated protein. JD506378 - Sequence 487402 from Patent EP1572962. JD159533 - Sequence 140557 from Patent EP1572962. JD089021 - Sequence 70045 from Patent EP1572962. JD105180 - Sequence 86204 from Patent EP1572962. JD193187 - Sequence 174211 from Patent EP1572962. JD551053 - Sequence 532077 from Patent EP1572962. JD368094 - Sequence 349118 from Patent EP1572962. JD171795 - Sequence 152819 from Patent EP1572962. JD435342 - Sequence 416366 from Patent EP1572962. JD249010 - Sequence 230034 from Patent EP1572962. JD060421 - Sequence 41445 from Patent EP1572962. HZ473918 - WO 2016002844-A/32: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL. AK024393 - Homo sapiens cDNA FLJ14331 fis, clone PLACE4000320. L35478 - Homo sapiens RAPT1 (RAPT1) mRNA, partial cds. BC127611 - Homo sapiens cDNA clone IMAGE:40031732, partial cds. MB485435 - JP 2019206516-A/8: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
| |
|
|
Biochemical and Signaling Pathways
|
|
Other Names for This Gene
|
|
Alternate Gene Symbols: AK126762, ENST00000376838.1, ENST00000376838.2, ENST00000376838.3, ENST00000376838.4, uc001asc.1, uc001asc.2, uc001asc.3, uc001asc.4 UCSC ID: ENST00000376838.5 RefSeq Accession: NM_004958
| |
|
|
Methods, Credits, and Use Restrictions
|
|
Click here
for details on how this gene model was made and data restrictions if any.
| |
|
|
|