Rat Gene Lair1 (RGD:1560048) Description and Page Index
  Description: No description available
Transcript (Including UTRs)
   Position: rn4 chr1:69,571,996-69,601,974 Size: 29,979 Total Exon Count: 8 Strand: +
Coding Region
   Position: rn4 chr1:69,572,027-69,601,943 Size: 29,917 Coding Exon Count: 8 

Page IndexSequence and LinksRGD Gene DataUniProtKB CommentsCTDMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:69,571,996-69,601,974)mRNAProtein (263 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed
ReactomeRGDStanford SOURCEUniProtKB

-  Additional Data from RGD
  RGD Gene: 1560048
Gene Symbol: Lair1
Name: leukocyte-associated immunoglobulin-like receptor 1
Curated Pubmed Papers: 15902436, 16041585
Entrez Gene: 574531
UniProt: P0C1X9
GenBank Nucleotide: AY863023, CH474075, DQ025756, NM_001029928
Genebank Protein: NP_001025099.1, AAX55651, AAY89039, EDL75802, NP_001025099, P0C1X9
UniGene: 149608
Ensembl Gene: ENSRNOG00000027733, ENSRNOG00000027733

-  Comments and Description Text from UniProtKB
  ID: LAIR1_RAT
DESCRIPTION: RecName: Full=Leukocyte-associated immunoglobulin-like receptor 1; Short=LAIR-1; Short=rLAIR1; AltName: CD_antigen=CD305; Flags: Precursor;
FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).
SUBUNIT: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in lymphoid and non-lymphoid organs.
DOMAIN: ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down- regulation of cell activation.
PTM: Phosphorylation at Tyr-227 and Tyr-257 activates it. May be phosphorylated by LCK (By similarity).
PTM: N-glycosylated (By similarity).
SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

Affymetrix All Exon Microarrays

           
Ratios

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub

ModBase Predicted Comparative 3D Structure on P0C1X9
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY863023 - Rattus norvegicus leukocyte-associated immunoglobulin-like receptor 1 (Lair1) mRNA, complete cds.
DQ025756 - Rattus norvegicus leukocyte-associated Ig-like receptor-1 (Lair1) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P0C1X9 (Reactome details) participates in the following event(s):

R-RNO-5686625 LAIR1 binds collagen
R-RNO-5696357 LAIR2 binds collagen
R-RNO-6798747 Exocytosis of tertiary granule membrane proteins
R-RNO-6799350 Exocytosis of specific granule membrane proteins
R-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-6798695 Neutrophil degranulation
R-RNO-1280218 Adaptive Immune System
R-RNO-168249 Innate Immune System
R-RNO-168256 Immune System

-  Other Names for This Gene
  Name: LAIR-1, leukocyte-associated Ig-like receptor 1, leukocyte-associated Ig-like receptor-1, leukocyte-associated immunoglobulin-like receptor 1, rLAIR1
RefSeq Accession: NM_001029928
Protein: P0C1X9 (aka LAIR1_RAT)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.