Rat Gene Lair1 (RGD:1560048) Description and Page Index
  Description: No description available
Transcript (Including UTRs)
   Position: rn4 chr1:69,571,996-69,601,974 Size: 29,979 Total Exon Count: 8 Strand: +
Coding Region
   Position: rn4 chr1:69,572,027-69,601,943 Size: 29,917 Coding Exon Count: 8 

Page IndexSequence and LinksRGD Gene DataUniProtKB CommentsCTDMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:69,571,996-69,601,974)mRNAProtein (263 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed
ReactomeRGDStanford SOURCEUniProtKB

-  Additional Data from RGD
  RGD Gene: 1560048
Gene Symbol: Lair1
Name: leukocyte-associated immunoglobulin-like receptor 1
Curated Pubmed Papers: 15902436, 16041585
Entrez Gene: 574531
UniProt: P0C1X9
GenBank Nucleotide: AY863023, CH474075, DQ025756, NM_001029928
Genebank Protein: NP_001025099.1, AAX55651, AAY89039, EDL75802, NP_001025099, P0C1X9
UniGene: 149608
Ensembl Gene: ENSRNOG00000027733, ENSRNOG00000027733

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Leukocyte-associated immunoglobulin-like receptor 1; Short=LAIR-1; Short=rLAIR1; AltName: CD_antigen=CD305; Flags: Precursor;
FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).
SUBUNIT: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in lymphoid and non-lymphoid organs.
DOMAIN: ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down- regulation of cell activation.
PTM: Phosphorylation at Tyr-227 and Tyr-257 activates it. May be phosphorylated by LCK (By similarity).
PTM: N-glycosylated (By similarity).
SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

Affymetrix All Exon Microarrays


-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub

ModBase Predicted Comparative 3D Structure on P0C1X9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AY863023 - Rattus norvegicus leukocyte-associated immunoglobulin-like receptor 1 (Lair1) mRNA, complete cds.
DQ025756 - Rattus norvegicus leukocyte-associated Ig-like receptor-1 (Lair1) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P0C1X9 (Reactome details) participates in the following event(s):

R-RNO-5686625 LAIR1 binds collagen
R-RNO-5696357 LAIR2 binds collagen
R-RNO-6798747 Exocytosis of tertiary granule membrane proteins
R-RNO-6799350 Exocytosis of specific granule membrane proteins
R-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-6798695 Neutrophil degranulation
R-RNO-1280218 Adaptive Immune System
R-RNO-168249 Innate Immune System
R-RNO-168256 Immune System

-  Other Names for This Gene
  Name: LAIR-1, leukocyte-associated Ig-like receptor 1, leukocyte-associated Ig-like receptor-1, leukocyte-associated immunoglobulin-like receptor 1, rLAIR1
RefSeq Accession: NM_001029928
Protein: P0C1X9 (aka LAIR1_RAT)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.