Rat Gene Tmbim1 (RGD:1359409) Description and Page Index
  Description: No description available
Transcript (Including UTRs)
   Position: rn4 chr9:73,614,825-73,632,005 Size: 17,181 Total Exon Count: 11 Strand: -
Coding Region
   Position: rn4 chr9:73,615,907-73,623,427 Size: 7,521 Coding Exon Count: 10 

Page IndexSequence and LinksRGD Gene DataCTDMicroarray ExpressionProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:73,614,825-73,632,005)mRNAProtein (309 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed
ReactomeRGDStanford SOURCEUniProtKB

-  Additional Data from RGD
  RGD Gene: 1359409
Gene Symbol: Tmbim1
Name: transmembrane BAX inhibitor motif containing 1
Curated Pubmed Papers: 12477932
Uncurated Pubmed Papers: 737633
Entrez Gene: 316516
UniProt: Q6AYE0
GenBank Nucleotide: BC079087, CH474004, NM_001007713
Genebank Protein: NP_001007714.1, EDL75346, EDL75347, EDL75348, EDL75349, EDL75350, NP_001007714, Q6AYE0, AAH79087
UniGene: 204023
Ensembl Gene: ENSRNOG00000014797, ENSRNOG00000014797
IMAGE CLONE: 7123233
MGC: BC079087

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

Affymetrix All Exon Microarrays


-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006214 - Bax_inhibitor_1-related

Pfam Domains:
PF01027 - Inhibitor of apoptosis-promoting Bax1

ModBase Predicted Comparative 3D Structure on Q6AYE0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005123 death receptor binding

Biological Process:
GO:0043086 negative regulation of catalytic activity
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902045 negative regulation of Fas signaling pathway
GO:1903077 negative regulation of protein localization to plasma membrane
GO:2000504 positive regulation of blood vessel remodeling

Cellular Component:
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle

-  Descriptions from all associated GenBank mRNAs
  BC079087 - Rattus norvegicus transmembrane BAX inhibitor motif containing 1, mRNA (cDNA clone MGC:94053 IMAGE:7123233), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6AYE0 (Reactome details) participates in the following event(s):

R-RNO-6799350 Exocytosis of specific granule membrane proteins
R-RNO-6798695 Neutrophil degranulation
R-RNO-168249 Innate Immune System
R-RNO-168256 Immune System

-  Other Names for This Gene
  Symbol: MGC94053
Name: similar to RECS1, transmembrane BAX inhibitor motif containing 1, transmembrane BAX inhibitor motif-containing protein 1
RefSeq Accession: NM_001007713
Protein: Q6AYE0

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.