Rat Gene Ispd (RGD:1359368) Description and Page Index
  Description: No description available
Transcript (Including UTRs)
   Position: rn4 chr6:55,139,155-55,419,630 Size: 280,476 Total Exon Count: 10 Strand: +
Coding Region
   Position: rn4 chr6:55,139,247-55,418,436 Size: 279,190 Coding Exon Count: 10 

Page IndexSequence and LinksRGD Gene DataUniProtKB CommentsCTDMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:55,139,155-55,419,630)mRNAProtein (447 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed
RGDStanford SOURCEUniProtKB

-  Additional Data from RGD
  RGD Gene: 1359368
Gene Symbol: Ispd
Name: isoprenoid synthase domain containing
Entrez Gene: 493574
UniProt: Q5S6T3, D3ZS46
GenBank Nucleotide: AY769991, AY769992, CH473947, NM_001008386
Genebank Protein: NP_001008387.1, AAV53695, AAV53696, EDM03319, NP_001008387, Q5S6T3
UniGene: 119606
Ensembl Gene: ENSRNOG00000006199, ENSRNOG00000006199

-  Comments and Description Text from UniProtKB
  ID: ISPD_RAT
DESCRIPTION: RecName: Full=Isoprenoid synthase domain-containing protein; EC=2.7.7.-; AltName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; AltName: Full=Notch1-induced protein;
FUNCTION: Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation (By similarity).
PATHWAY: Protein modification; protein glycosylation.
SIMILARITY: Belongs to the IspD family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U34A Rat Chip

      
      
      
    
     
    
   
Ratios
      
      
      
    
     
    
   
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Affymetrix All Exon Microarrays

           
Ratios

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001228 - ISPD_synthase
IPR018294 - ISPD_synthase_CS

Pfam Domains:
PF01128 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

ModBase Predicted Comparative 3D Structure on Q5S6T3
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042803 protein homodimerization activity
GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity
GO:0070567 cytidylyltransferase activity

Biological Process:
GO:0006486 protein glycosylation
GO:0007411 axon guidance
GO:0008299 isoprenoid biosynthetic process
GO:0035269 protein O-linked mannosylation

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AY769991 - Rattus norvegicus notch1-induced protein mRNA, complete cds.
AY769992 - Rattus norvegicus notch1-induced protein mRNA, complete cds.

-  Other Names for This Gene
  Symbol: LOC493574, Nip
Name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein, isoprenoid synthase domain-containing protein, notch1-induced protein
RefSeq Accession: NM_001008386
Protein: Q5S6T3 (aka ISPD_RAT)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.