Rat Gene Ispd (RGD:1359368) Description and Page Index
  Description: No description available
Transcript (Including UTRs)
   Position: rn4 chr6:55,139,155-55,419,630 Size: 280,476 Total Exon Count: 10 Strand: +
Coding Region
   Position: rn4 chr6:55,139,247-55,418,436 Size: 279,190 Coding Exon Count: 10 

Page IndexSequence and LinksRGD Gene DataUniProtKB CommentsCTDMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:55,139,155-55,419,630)mRNAProtein (447 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed

-  Additional Data from RGD
  RGD Gene: 1359368
Gene Symbol: Ispd
Name: isoprenoid synthase domain containing
Entrez Gene: 493574
UniProt: Q5S6T3, D3ZS46
GenBank Nucleotide: AY769991, AY769992, CH473947, NM_001008386
Genebank Protein: NP_001008387.1, AAV53695, AAV53696, EDM03319, NP_001008387, Q5S6T3
UniGene: 119606
Ensembl Gene: ENSRNOG00000006199, ENSRNOG00000006199

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Isoprenoid synthase domain-containing protein; EC=2.7.7.-; AltName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; AltName: Full=Notch1-induced protein;
FUNCTION: Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation (By similarity).
PATHWAY: Protein modification; protein glycosylation.
SIMILARITY: Belongs to the IspD family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U34A Rat Chip


Affymetrix All Exon Microarrays


-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001228 - ISPD_synthase
IPR018294 - ISPD_synthase_CS

Pfam Domains:
PF01128 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

ModBase Predicted Comparative 3D Structure on Q5S6T3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042803 protein homodimerization activity
GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity
GO:0070567 cytidylyltransferase activity

Biological Process:
GO:0006486 protein glycosylation
GO:0007411 axon guidance
GO:0008299 isoprenoid biosynthetic process
GO:0035269 protein O-linked mannosylation

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AY769991 - Rattus norvegicus notch1-induced protein mRNA, complete cds.
AY769992 - Rattus norvegicus notch1-induced protein mRNA, complete cds.

-  Other Names for This Gene
  Symbol: LOC493574, Nip
Name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein, isoprenoid synthase domain-containing protein, notch1-induced protein
RefSeq Accession: NM_001008386
Protein: Q5S6T3 (aka ISPD_RAT)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.