Rat Gene P2ry13 (RGD:1302941) Description and Page Index
  Description: G-protein coupled receptor activated by ADP and 2MeSADP and inhibited by P2Y antagonist AR-C69931MX
Transcript (Including UTRs)
   Position: rn4 chr2:148,600,612-148,601,622 Size: 1,011 Total Exon Count: 1 Strand: -
Coding Region
   Position: rn4 chr2:148,600,612-148,601,622 Size: 1,011 Coding Exon Count: 1 

Page IndexSequence and LinksRGD Gene DataUniProtKB CommentsCTDMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:148,600,612-148,601,622)mRNAProtein (336 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed
ReactomeRGDStanford SOURCEUniProtKB

-  Additional Data from RGD
  RGD Gene: 1302941
Gene Symbol: P2ry13
Name: purinergic receptor P2Y, G-protein coupled, 13
Curated Pubmed Papers: 15183123
Uncurated Pubmed Papers: 1304000
Entrez Gene: 310444
UniProt: Q6GUG4
GenBank Nucleotide: AY639875, CH474003, NM_001002853
Genebank Protein: NP_001002853.1, AAT57664, EDM14849, NP_001002853, Q6GUG4
UniGene: 209780
Ensembl Gene: ENSRNOG00000029756, ENSRNOG00000029756

-  Comments and Description Text from UniProtKB
  ID: P2Y13_RAT
DESCRIPTION: RecName: Full=P2Y purinoceptor 13; Short=P2Y13;
FUNCTION: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highest levels in spleen, liver brain and kidney. Lower but significant level are also detected in intestine, stomach, skeletal muscle, testis, heart and lung.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

Affymetrix All Exon Microarrays

           
Ratios

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor
IPR008109 - P2Y13_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on Q6GUG4
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0045028 G-protein coupled purinergic nucleotide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0071407 cellular response to organic cyclic compound

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY639875 - Rattus norvegicus purinergic receptor P2Y13 (P2ry13) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6GUG4 (Reactome details) participates in the following event(s):

R-RNO-417843 P2Y13 receptor can bind ADP
R-RNO-749454 The Ligand:GPCR:Gi complex dissociates
R-RNO-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-RNO-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-RNO-417957 P2Y receptors
R-RNO-418594 G alpha (i) signalling events
R-RNO-418038 Nucleotide-like (purinergic) receptors
R-RNO-388396 GPCR downstream signalling
R-RNO-373076 Class A/1 (Rhodopsin-like receptors)
R-RNO-372790 Signaling by GPCR
R-RNO-500792 GPCR ligand binding
R-RNO-162582 Signal Transduction

-  Other Names for This Gene
  Symbol: P2y13
Name: P2Y purinoceptor 13, purinergic receptor P2Y, G-protein coupled, 13
RefSeq Accession: NM_001002853
Protein: Q6GUG4 (aka P2Y13_RAT)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.