Mouse Gene Ctnnb1 (ENSMUST00000178812.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus catenin (cadherin associated protein), beta 1 (Ctnnb1), transcript variant 2, mRNA. (from RefSeq NM_001165902) RefSeq Summary (NM_007614): This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]. Gencode Transcript: ENSMUST00000178812.8 Gencode Gene: ENSMUSG00000006932.17 Transcript (Including UTRs) Position: mm10 chr9:120,933,572-120,959,780 Size: 26,209 Total Exon Count: 15 Strand: + Coding Region Position: mm10 chr9:120,950,221-120,959,517 Size: 9,297 Coding Exon Count: 14
ID:CTNB1_MOUSE DESCRIPTION: RecName: Full=Catenin beta-1; AltName: Full=Beta-catenin; FUNCTION: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity). SUBUNIT: Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F- actin when assembled in the complex. Alternatively, the CTNNA1- containing complex may be linked to F-actin by other proteins such as LIMA1. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9 and possibly also RUVBL1 and CHD8. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding (By similarity). Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1 (By similarity). Interacts with GLIS2. Interacts with SLC30A9. Interacts with XIRP1. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain) and with EMD (By similarity). Interacts with SCRIB. Interacts with TNIK and TCF7L2. Interacts with SESTD1 and TRPC4 (By similarity). Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1. Interacts with CAV1. Interacts with PTPRJ (By similarity). Interacts with TRPV4; the TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. Interacts with PKT7 (By similarity). Interacts with FAT1 (via the cytoplasmic domain) (By similarity). Interacts with CDK2, NDRG2 and NANOS1 (By similarity). Interacts with NEK2 and CDK5 (By similarity). Interacts with PTK6 (By similarity). Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription (By similarity). INTERACTION: P25054:APC (xeno); NbExp=8; IntAct=EBI-397872, EBI-727707; O15169:AXIN1 (xeno); NbExp=5; IntAct=EBI-397872, EBI-710484; P09803:Cdh1; NbExp=13; IntAct=EBI-397872, EBI-984420; P45481:Crebbp; NbExp=2; IntAct=EBI-397872, EBI-296306; P26231:Ctnna1; NbExp=2; IntAct=EBI-397872, EBI-647895; Q9NSA3:CTNNBIP1 (xeno); NbExp=7; IntAct=EBI-397872, EBI-747082; P27782:Lef1; NbExp=6; IntAct=EBI-397872, EBI-984464; P97458:Prop1; NbExp=2; IntAct=EBI-397872, EBI-937831; Q9DBG9:Tax1bp3; NbExp=6; IntAct=EBI-397872, EBI-1161647; SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, adherens junction (By similarity). Cell junction (By similarity). Cell membrane (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Co-localizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells (By similarity). PTM: Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr- 41 to Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding (By similarity). Phosphorylated on Ser-33 and Ser-37 by HIPK2. This phosphorylation triggers proteasomal degradation. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization (By similarity). Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity (By similarity). PTM: Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity). SIMILARITY: Belongs to the beta-catenin family. SIMILARITY: Contains 12 ARM repeats. SEQUENCE CAUTION: Sequence=AAH06739.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02248
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK132398 - Mus musculus 1 day pregnant adult female mammary gland cDNA, RIKEN full-length enriched library, clone:4222404F16 product:catenin beta, full insert sequence. AY751549 - Mus musculus MES-cadenin-like (Mesc) mRNA, complete sequence. BC048153 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone MGC:61364 IMAGE:5709247), complete cds. BC053065 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone MGC:62386 IMAGE:5709247), complete cds. AK020013 - Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830416C23 product:catenin beta, full insert sequence. AK133656 - Mus musculus adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330431B01 product:catenin beta, full insert sequence. AK035311 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530013P13 product:catenin beta, full insert sequence. AK018515 - Mus musculus adult male colon cDNA, RIKEN full-length enriched library, clone:9030417H18 product:catenin beta, full insert sequence. M90364 - Mouse (clone pMCAT) beta-catenin mRNA, complete cds. AK201646 - Mus musculus cDNA, clone:Y1G0138O13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK203436 - Mus musculus cDNA, clone:Y1G0144N22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK178155 - Mus musculus cDNA, clone:Y0G0105K08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK201809 - Mus musculus cDNA, clone:Y1G0139G24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK199952 - Mus musculus cDNA, clone:Y1G0132N24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. JC204499 - Sequence 4 from Patent EP2367418. AK135743 - Mus musculus in vitro fertilized eggs cDNA, RIKEN full-length enriched library, clone:7420409L11 product:catenin beta, full insert sequence. BC043078 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone IMAGE:5721147). AK179260 - Mus musculus cDNA, clone:Y0G0109K18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK197753 - Mus musculus cDNA, clone:Y1G0126B01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. BC043481 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone IMAGE:5148300), partial cds. AK211747 - Mus musculus cDNA, clone:Y2G0122L19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK184861 - Mus musculus cDNA, clone:Y0G0131M10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. JC204500 - Sequence 5 from Patent EP2367418. AK219273 - Mus musculus cDNA, clone:Y2G0147P07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK205694 - Mus musculus cDNA, clone:Y2G0102H21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK179148 - Mus musculus cDNA, clone:Y0G0109F01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK189807 - Mus musculus cDNA, clone:Y0G0150L14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK190684 - Mus musculus cDNA, clone:Y1G0103H22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK196547 - Mus musculus cDNA, clone:Y1G0122C19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK197664 - Mus musculus cDNA, clone:Y1G0125M09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK202371 - Mus musculus cDNA, clone:Y1G0141E15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK219949 - Mus musculus cDNA, clone:Y2G0150D21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK204053 - Mus musculus cDNA, clone:Y1G0147C18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK180997 - Mus musculus cDNA, clone:Y0G0116J09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK203824 - Mus musculus cDNA, clone:Y1G0146F07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK191852 - Mus musculus cDNA, clone:Y1G0107C14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK196236 - Mus musculus cDNA, clone:Y1G0121D15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. BC006739 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone IMAGE:3156732), complete cds. AK197513 - Mus musculus cDNA, clone:Y1G0125F07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK210588 - Mus musculus cDNA, clone:Y2G0118O21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search. AK214825 - Mus musculus cDNA, clone:Y2G0133C06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04310 - Wnt signaling pathway mmu04510 - Focal adhesion mmu04520 - Adherens junction mmu04530 - Tight junction mmu04670 - Leukocyte transendothelial migration mmu04916 - Melanogenesis mmu05100 - Bacterial invasion of epithelial cells mmu05200 - Pathways in cancer mmu05210 - Colorectal cancer mmu05213 - Endometrial cancer mmu05215 - Prostate cancer mmu05216 - Thyroid cancer mmu05217 - Basal cell carcinoma mmu05412 - Arrhythmogenic right ventricular cardiomyopathy (ARVC)
BioCarta from NCI Cancer Genome Anatomy Project m_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2 m_ps1Pathway - Presenilin action in Notch and Wnt signaling m_wntPathway - WNT Signaling Pathway m_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages m_cell2cellPathway - Cell to Cell Adhesion Signaling m_tffPathway - Trefoil Factors Initiate Mucosal Healing
Reactome (by CSHL, EBI, and GO)
Protein Q02248 (Reactome details) participates in the following event(s):
R-MMU-209096 Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin R-MMU-195304 Association of beta-catenin with the destruction complex R-MMU-201685 Beta-catenin is released from the destruction complex R-MMU-3299569 Beta-catenin displaces TLE:HDAC1 from TCF/LEF R-MMU-3769383 CBY1 binds beta-catenin R-MMU-3772430 CTNNBIP1 binds beta-catenin R-MMU-5368580 CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression R-MMU-5626938 Beta-catenin binds SOX proteins R-MMU-202969 Caspase mediated cleavage of beta-catenin R-MMU-3134883 Beta-catenin enhances association of IRF3 with CBP/p300 R-MMU-195275 Phosphorylation of APC component of the destruction complex R-MMU-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 R-MMU-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex R-MMU-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex R-MMU-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 R-MMU-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 R-MMU-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha R-MMU-5672304 IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 R-MMU-201712 Beta-catenin:TCF associates with BCL9 and PYGO R-MMU-3322422 Beta-catenin recruits SMARCA4 R-MMU-3322424 Beta-catenin recruits CDC73 and LEO1 R-MMU-3322427 Beta-catenin recruits CBP/p300 R-MMU-3451153 Beta-catenin recruits TRRAP/KAT5 HAT components R-MMU-5665608 TCF:Beta-catenin binds SOX proteins R-MMU-3364014 Recruitment of SET1 methyltransferase complex R-MMU-3769394 AKT phosphorylates CBY1 R-MMU-3769393 YWHAZ binds p-CBY:CTNNB1 R-MMU-4411383 NLK phosphorylates TCF/LEF R-MMU-8951428 RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) R-MMU-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) R-MMU-3364026 SET1 complex trimethylates H3K4 at the MYC gene R-MMU-3769391 XPO1 binds the beta-catenin:CBY complex R-MMU-419002 Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin R-MMU-375140 CDO binds promyogenic cadherins R-MMU-5357477 PAK1-3 phosphorylates VE-cadherin R-MMU-195253 Degradation of beta-catenin by the destruction complex R-MMU-201681 TCF dependent signaling in response to WNT R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex R-MMU-3769402 Deactivation of the beta-catenin transactivating complex R-MMU-351906 Apoptotic cleavage of cell adhesion proteins R-MMU-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-MMU-196299 Beta-catenin phosphorylation cascade R-MMU-5626467 RHO GTPases activate IQGAPs R-MMU-195721 Signaling by WNT R-MMU-4086398 Ca2+ pathway R-MMU-8951430 RUNX3 regulates WNT signaling R-MMU-111465 Apoptotic cleavage of cellular proteins R-MMU-1834949 Cytosolic sensors of pathogen-associated DNA R-MMU-195258 RHO GTPase Effectors R-MMU-162582 Signal Transduction R-MMU-3858494 Beta-catenin independent WNT signaling R-MMU-8878159 Transcriptional regulation by RUNX3 R-MMU-75153 Apoptotic execution phase R-MMU-418990 Adherens junctions interactions R-MMU-168249 Innate Immune System R-MMU-194315 Signaling by Rho GTPases R-MMU-375170 CDO in myogenesis R-MMU-212436 Generic Transcription Pathway R-MMU-109581 Apoptosis R-MMU-5218920 VEGFR2 mediated vascular permeability R-MMU-421270 Cell-cell junction organization R-MMU-168256 Immune System R-MMU-525793 Myogenesis R-MMU-73857 RNA Polymerase II Transcription R-MMU-5357801 Programmed Cell Death R-MMU-4420097 VEGFA-VEGFR2 Pathway R-MMU-446728 Cell junction organization R-MMU-1266738 Developmental Biology R-MMU-74160 Gene expression (Transcription) R-MMU-194138 Signaling by VEGF R-MMU-1500931 Cell-Cell communication R-MMU-9006934 Signaling by Receptor Tyrosine Kinases