Mouse Gene Ctnnb1 (ENSMUST00000178812.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus catenin (cadherin associated protein), beta 1 (Ctnnb1), transcript variant 2, mRNA. (from RefSeq NM_001165902)
RefSeq Summary (NM_007614): This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gencode Transcript: ENSMUST00000178812.8
Gencode Gene: ENSMUSG00000006932.17
Transcript (Including UTRs)
   Position: mm10 chr9:120,933,572-120,959,780 Size: 26,209 Total Exon Count: 15 Strand: +
Coding Region
   Position: mm10 chr9:120,950,221-120,959,517 Size: 9,297 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:120,933,572-120,959,780)mRNA (may differ from genome)Protein (781 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
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-  Comments and Description Text from UniProtKB
  ID: CTNB1_MOUSE
DESCRIPTION: RecName: Full=Catenin beta-1; AltName: Full=Beta-catenin;
FUNCTION: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).
SUBUNIT: Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F- actin when assembled in the complex. Alternatively, the CTNNA1- containing complex may be linked to F-actin by other proteins such as LIMA1. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9 and possibly also RUVBL1 and CHD8. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding (By similarity). Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1 (By similarity). Interacts with GLIS2. Interacts with SLC30A9. Interacts with XIRP1. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain) and with EMD (By similarity). Interacts with SCRIB. Interacts with TNIK and TCF7L2. Interacts with SESTD1 and TRPC4 (By similarity). Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1. Interacts with CAV1. Interacts with PTPRJ (By similarity). Interacts with TRPV4; the TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. Interacts with PKT7 (By similarity). Interacts with FAT1 (via the cytoplasmic domain) (By similarity). Interacts with CDK2, NDRG2 and NANOS1 (By similarity). Interacts with NEK2 and CDK5 (By similarity). Interacts with PTK6 (By similarity). Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription (By similarity).
INTERACTION: P25054:APC (xeno); NbExp=8; IntAct=EBI-397872, EBI-727707; O15169:AXIN1 (xeno); NbExp=5; IntAct=EBI-397872, EBI-710484; P09803:Cdh1; NbExp=13; IntAct=EBI-397872, EBI-984420; P45481:Crebbp; NbExp=2; IntAct=EBI-397872, EBI-296306; P26231:Ctnna1; NbExp=2; IntAct=EBI-397872, EBI-647895; Q9NSA3:CTNNBIP1 (xeno); NbExp=7; IntAct=EBI-397872, EBI-747082; P27782:Lef1; NbExp=6; IntAct=EBI-397872, EBI-984464; P97458:Prop1; NbExp=2; IntAct=EBI-397872, EBI-937831; Q9DBG9:Tax1bp3; NbExp=6; IntAct=EBI-397872, EBI-1161647;
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, adherens junction (By similarity). Cell junction (By similarity). Cell membrane (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Co-localizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells (By similarity).
PTM: Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr- 41 to Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding (By similarity). Phosphorylated on Ser-33 and Ser-37 by HIPK2. This phosphorylation triggers proteasomal degradation. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization (By similarity). Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity (By similarity).
PTM: Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity).
SIMILARITY: Belongs to the beta-catenin family.
SIMILARITY: Contains 12 ARM repeats.
SEQUENCE CAUTION: Sequence=AAH06739.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.0093-0.355 Picture PostScript Text
3' UTR -59.30263-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000225 - Armadillo
IPR013284 - Beta-catenin

Pfam Domains:
PF00514 - Armadillo/beta-catenin-like repeat

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1DOW - X-ray 1I7W - X-ray 1I7X - X-ray 1JPP - X-ray 1M1E - X-ray 1V18 - X-ray 2BCT - X-ray 3BCT - X-ray 3OUW - X-ray 3OUX - X-ray


ModBase Predicted Comparative 3D Structure on Q02248
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030331 estrogen receptor binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035257 nuclear hormone receptor binding
GO:0044325 ion channel binding
GO:0044877 macromolecular complex binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0050998 nitric-oxide synthase binding
GO:0070411 I-SMAD binding
GO:0070491 repressing transcription factor binding
GO:0097718 disordered domain specific binding
GO:1990226 histone methyltransferase binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000578 embryonic axis specification
GO:0000904 cell morphogenesis involved in differentiation
GO:0001501 skeletal system development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001711 endodermal cell fate commitment
GO:0001764 neuron migration
GO:0001822 kidney development
GO:0001840 neural plate development
GO:0001944 vasculature development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002089 lens morphogenesis in camera-type eye
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003338 metanephros morphogenesis
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007268 chemical synaptic transmission
GO:0007398 ectoderm development
GO:0007399 nervous system development
GO:0007403 glial cell fate determination
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009948 anterior/posterior axis specification
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0009987 cellular process
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010 Schwann cell proliferation
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0016525 negative regulation of angiogenesis
GO:0019827 stem cell population maintenance
GO:0021819 layer formation in cerebral cortex
GO:0022009 central nervous system vasculogenesis
GO:0022405 hair cycle process
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030217 T cell differentiation
GO:0030316 osteoclast differentiation
GO:0030324 lung development
GO:0030539 male genitalia development
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0030997 regulation of centriole-centriole cohesion
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031641 regulation of myelination
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032355 response to estradiol
GO:0033077 T cell differentiation in thymus
GO:0033234 negative regulation of protein sumoylation
GO:0034097 response to cytokine
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0034613 cellular protein localization
GO:0035050 embryonic heart tube development
GO:0035112 genitalia morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0036023 embryonic skeletal limb joint morphogenesis
GO:0042127 regulation of cell proliferation
GO:0042129 regulation of T cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0043588 skin development
GO:0043627 response to estrogen
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045453 bone resorption
GO:0045595 regulation of cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045976 negative regulation of mitotic cell cycle, embryonic
GO:0048096 chromatin-mediated maintenance of transcription
GO:0048469 cell maturation
GO:0048489 synaptic vesicle transport
GO:0048513 animal organ development
GO:0048538 thymus development
GO:0048599 oocyte development
GO:0048617 embryonic foregut morphogenesis
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050808 synapse organization
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051145 smooth muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0051569 regulation of histone H3-K4 methylation
GO:0051884 regulation of anagen
GO:0051973 positive regulation of telomerase activity
GO:0060038 cardiac muscle cell proliferation
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060439 trachea morphogenesis
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060479 lung cell differentiation
GO:0060484 lung-associated mesenchyme development
GO:0060485 mesenchyme development
GO:0060492 lung induction
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 hair follicle placode formation
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0060982 coronary artery morphogenesis
GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061154 endothelial tube morphogenesis
GO:0061198 fungiform papilla formation
GO:0061324 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0061549 sympathetic ganglion development
GO:0061550 cranial ganglion development
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071681 cellular response to indole-3-methanol
GO:0072001 renal system development
GO:0072033 renal vesicle formation
GO:0072053 renal inner medulla development
GO:0072054 renal outer medulla development
GO:0072079 nephron tubule formation
GO:0072132 mesenchyme morphogenesis
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0090279 regulation of calcium ion import
GO:0098609 cell-cell adhesion
GO:1901215 negative regulation of neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1904173 regulation of histone demethylase activity (H3-K4 specific)
GO:1904499 regulation of chromatin-mediated maintenance of transcription
GO:1904501 positive regulation of chromatin-mediated maintenance of transcription
GO:1904793 regulation of euchromatin binding
GO:1904796 regulation of core promoter binding
GO:1904798 positive regulation of core promoter binding
GO:1904888 cranial skeletal system development
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1990138 neuron projection extension
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990403 embryonic brain development
GO:1990791 dorsal root ganglion development
GO:2000008 regulation of protein localization to cell surface
GO:2000017 positive regulation of determination of dorsal identity
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2001234 negative regulation of apoptotic signaling pathway

Cellular Component:
GO:0000922 spindle pole
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005916 fascia adherens
GO:0005923 bicellular tight junction
GO:0005938 cell cortex
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0016600 flotillin complex
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030877 beta-catenin destruction complex
GO:0031253 cell projection membrane
GO:0031528 microvillus membrane
GO:0031965 nuclear membrane
GO:0032991 macromolecular complex
GO:0032993 protein-DNA complex
GO:0034750 Scrib-APC-beta-catenin complex
GO:0043198 dendritic shaft
GO:0043296 apical junction complex
GO:0044798 nuclear transcription factor complex
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070369 beta-catenin-TCF7L2 complex
GO:0071944 cell periphery
GO:1990907 beta-catenin-TCF complex
GO:1990909 Wnt signalosome
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  AK132398 - Mus musculus 1 day pregnant adult female mammary gland cDNA, RIKEN full-length enriched library, clone:4222404F16 product:catenin beta, full insert sequence.
AY751549 - Mus musculus MES-cadenin-like (Mesc) mRNA, complete sequence.
BC048153 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone MGC:61364 IMAGE:5709247), complete cds.
BC053065 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone MGC:62386 IMAGE:5709247), complete cds.
AK020013 - Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830416C23 product:catenin beta, full insert sequence.
AK133656 - Mus musculus adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330431B01 product:catenin beta, full insert sequence.
AK035311 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530013P13 product:catenin beta, full insert sequence.
AK018515 - Mus musculus adult male colon cDNA, RIKEN full-length enriched library, clone:9030417H18 product:catenin beta, full insert sequence.
M90364 - Mouse (clone pMCAT) beta-catenin mRNA, complete cds.
AK201646 - Mus musculus cDNA, clone:Y1G0138O13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK203436 - Mus musculus cDNA, clone:Y1G0144N22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK178155 - Mus musculus cDNA, clone:Y0G0105K08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK201809 - Mus musculus cDNA, clone:Y1G0139G24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK199952 - Mus musculus cDNA, clone:Y1G0132N24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
JC204499 - Sequence 4 from Patent EP2367418.
AK135743 - Mus musculus in vitro fertilized eggs cDNA, RIKEN full-length enriched library, clone:7420409L11 product:catenin beta, full insert sequence.
BC043078 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone IMAGE:5721147).
AK179260 - Mus musculus cDNA, clone:Y0G0109K18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK197753 - Mus musculus cDNA, clone:Y1G0126B01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
BC043481 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone IMAGE:5148300), partial cds.
AK211747 - Mus musculus cDNA, clone:Y2G0122L19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK184861 - Mus musculus cDNA, clone:Y0G0131M10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
JC204500 - Sequence 5 from Patent EP2367418.
AK219273 - Mus musculus cDNA, clone:Y2G0147P07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK205694 - Mus musculus cDNA, clone:Y2G0102H21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK179148 - Mus musculus cDNA, clone:Y0G0109F01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK189807 - Mus musculus cDNA, clone:Y0G0150L14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK190684 - Mus musculus cDNA, clone:Y1G0103H22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK196547 - Mus musculus cDNA, clone:Y1G0122C19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK197664 - Mus musculus cDNA, clone:Y1G0125M09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK202371 - Mus musculus cDNA, clone:Y1G0141E15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK219949 - Mus musculus cDNA, clone:Y2G0150D21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK204053 - Mus musculus cDNA, clone:Y1G0147C18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK180997 - Mus musculus cDNA, clone:Y0G0116J09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK203824 - Mus musculus cDNA, clone:Y1G0146F07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK191852 - Mus musculus cDNA, clone:Y1G0107C14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK196236 - Mus musculus cDNA, clone:Y1G0121D15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
BC006739 - Mus musculus catenin (cadherin associated protein), beta 1, mRNA (cDNA clone IMAGE:3156732), complete cds.
AK197513 - Mus musculus cDNA, clone:Y1G0125F07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK210588 - Mus musculus cDNA, clone:Y2G0118O21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.
AK214825 - Mus musculus cDNA, clone:Y2G0133C06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007130, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04310 - Wnt signaling pathway
mmu04510 - Focal adhesion
mmu04520 - Adherens junction
mmu04530 - Tight junction
mmu04670 - Leukocyte transendothelial migration
mmu04916 - Melanogenesis
mmu05100 - Bacterial invasion of epithelial cells
mmu05200 - Pathways in cancer
mmu05210 - Colorectal cancer
mmu05213 - Endometrial cancer
mmu05215 - Prostate cancer
mmu05216 - Thyroid cancer
mmu05217 - Basal cell carcinoma
mmu05412 - Arrhythmogenic right ventricular cardiomyopathy (ARVC)

BioCarta from NCI Cancer Genome Anatomy Project
m_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2
m_ps1Pathway - Presenilin action in Notch and Wnt signaling
m_wntPathway - WNT Signaling Pathway
m_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
m_cell2cellPathway - Cell to Cell Adhesion Signaling
m_tffPathway - Trefoil Factors Initiate Mucosal Healing

Reactome (by CSHL, EBI, and GO)

Protein Q02248 (Reactome details) participates in the following event(s):

R-MMU-209096 Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin
R-MMU-195304 Association of beta-catenin with the destruction complex
R-MMU-201685 Beta-catenin is released from the destruction complex
R-MMU-3299569 Beta-catenin displaces TLE:HDAC1 from TCF/LEF
R-MMU-3769383 CBY1 binds beta-catenin
R-MMU-3772430 CTNNBIP1 binds beta-catenin
R-MMU-5368580 CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression
R-MMU-5626938 Beta-catenin binds SOX proteins
R-MMU-202969 Caspase mediated cleavage of beta-catenin
R-MMU-3134883 Beta-catenin enhances association of IRF3 with CBP/p300
R-MMU-195275 Phosphorylation of APC component of the destruction complex
R-MMU-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
R-MMU-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
R-MMU-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
R-MMU-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
R-MMU-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
R-MMU-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha
R-MMU-5672304 IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
R-MMU-201712 Beta-catenin:TCF associates with BCL9 and PYGO
R-MMU-3322422 Beta-catenin recruits SMARCA4
R-MMU-3322424 Beta-catenin recruits CDC73 and LEO1
R-MMU-3322427 Beta-catenin recruits CBP/p300
R-MMU-3451153 Beta-catenin recruits TRRAP/KAT5 HAT components
R-MMU-5665608 TCF:Beta-catenin binds SOX proteins
R-MMU-3364014 Recruitment of SET1 methyltransferase complex
R-MMU-3769394 AKT phosphorylates CBY1
R-MMU-3769393 YWHAZ binds p-CBY:CTNNB1
R-MMU-4411383 NLK phosphorylates TCF/LEF
R-MMU-8951428 RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)
R-MMU-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
R-MMU-3364026 SET1 complex trimethylates H3K4 at the MYC gene
R-MMU-3769391 XPO1 binds the beta-catenin:CBY complex
R-MMU-419002 Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin
R-MMU-375140 CDO binds promyogenic cadherins
R-MMU-5357477 PAK1-3 phosphorylates VE-cadherin
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-201681 TCF dependent signaling in response to WNT
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-351906 Apoptotic cleavage of cell adhesion proteins
R-MMU-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-MMU-196299 Beta-catenin phosphorylation cascade
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-195721 Signaling by WNT
R-MMU-4086398 Ca2+ pathway
R-MMU-8951430 RUNX3 regulates WNT signaling
R-MMU-111465 Apoptotic cleavage of cellular proteins
R-MMU-1834949 Cytosolic sensors of pathogen-associated DNA
R-MMU-195258 RHO GTPase Effectors
R-MMU-162582 Signal Transduction
R-MMU-3858494 Beta-catenin independent WNT signaling
R-MMU-8878159 Transcriptional regulation by RUNX3
R-MMU-75153 Apoptotic execution phase
R-MMU-418990 Adherens junctions interactions
R-MMU-168249 Innate Immune System
R-MMU-194315 Signaling by Rho GTPases
R-MMU-375170 CDO in myogenesis
R-MMU-212436 Generic Transcription Pathway
R-MMU-109581 Apoptosis
R-MMU-5218920 VEGFR2 mediated vascular permeability
R-MMU-421270 Cell-cell junction organization
R-MMU-168256 Immune System
R-MMU-525793 Myogenesis
R-MMU-73857 RNA Polymerase II Transcription
R-MMU-5357801 Programmed Cell Death
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-446728 Cell junction organization
R-MMU-1266738 Developmental Biology
R-MMU-74160 Gene expression (Transcription)
R-MMU-194138 Signaling by VEGF
R-MMU-1500931 Cell-Cell communication
R-MMU-9006934 Signaling by Receptor Tyrosine Kinases

-  Other Names for This Gene
  Alternate Gene Symbols: Catnb, CTNB1_MOUSE, NM_001165902, Q02248, Q922W1, Q9D335, uc012hcn.1, uc012hcn.2
UCSC ID: uc012hcn.2
RefSeq Accession: NM_007614
Protein: Q02248 (aka CTNB1_MOUSE or CTNB_MOUSE)
CCDS: CCDS23630.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.