Mouse Gene Cmtr2 (ENSMUST00000056972.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus cap methyltransferase 2 (Cmtr2), mRNA. (from RefSeq NM_146215)
Gencode Transcript: ENSMUST00000056972.5
Gencode Gene: ENSMUSG00000046441.5
Transcript (Including UTRs)
   Position: mm10 chr8:110,217,989-110,224,486 Size: 6,498 Total Exon Count: 2 Strand: +
Coding Region
   Position: mm10 chr8:110,221,060-110,223,363 Size: 2,304 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:110,217,989-110,224,486)mRNA (may differ from genome)Protein (767 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FTSJ1_MOUSE
DESCRIPTION: RecName: Full=FtsJ methyltransferase domain-containing protein 1; EC=2.1.1.-;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the methyltransferase superfamily. RlmE family. Adrift subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.60118-0.361 Picture PostScript Text
3' UTR -275.101123-0.245 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025807 - Adrift_MeTrfase
IPR002877 - rRNA_MeTrfase_FtsJ_dom

Pfam Domains:
PF01728 - FtsJ-like methyltransferase

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q8BWQ4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsemblEnsemblWormBase 
 Protein Sequence Protein SequenceProtein Sequence 
 Alignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0006370 7-methylguanosine mRNA capping
GO:0006397 mRNA processing
GO:0032259 methylation
GO:0097310 cap2 mRNA methylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK158368 - Mus musculus adult inner ear cDNA, RIKEN full-length enriched library, clone:F930109O19 product:Similar to hypothetical protein FLJ11171 (H. sapiens) homolog [Mus musculus], full insert sequence.
AK032855 - Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720463C10 product:similar to CDNA FLJ11171 FIS, CLONE PLACE1007317, WEAKLY SIMILAR TO DROSOPHILA MELANOGASTER ADRIFT MRNA [Homo sapiens], full insert sequence.
BC025546 - Mus musculus FtsJ methyltransferase domain containing 1, mRNA (cDNA clone MGC:38131 IMAGE:5320939), complete cds.
AK050315 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730036L12 product:similar to CDNA FLJ11171 FIS, CLONE PLACE1007317, WEAKLY SIMILAR TO DROSOPHILA MELANOGASTER ADRIFT MRNA [Homo sapiens], full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: FTSJ1_MOUSE, Ftsjd1, NM_146215, Q3TYT6, Q8BWQ4, Q8R3E7, uc009nkp.1, uc009nkp.2, uc009nkp.3
UCSC ID: uc009nkp.3
RefSeq Accession: NM_146215
Protein: Q8BWQ4 (aka FTSJ1_MOUSE)
CCDS: CCDS22662.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.