Mouse Gene Ptdss2 (ENSMUST00000026568.9) Description and Page Index
  Description: Mus musculus phosphatidylserine synthase 2 (Ptdss2), mRNA. (from RefSeq NM_013782)
Gencode Transcript: ENSMUST00000026568.9
Gencode Gene: ENSMUSG00000025495.15
Transcript (Including UTRs)
   Position: mm10 chr7:141,131,286-141,157,606 Size: 26,321 Total Exon Count: 12 Strand: +
Coding Region
   Position: mm10 chr7:141,131,402-141,155,520 Size: 24,119 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:141,131,286-141,157,606)mRNA (may differ from genome)Protein (473 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Phosphatidylserine synthase 2; Short=PSS-2; Short=PtdSer synthase 2; EC=; AltName: Full=Serine-exchange enzyme II;
FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.
CATALYTIC ACTIVITY: L-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
ENZYME REGULATION: Almost complete inhibition by ethanolamine in both the mitochondria-associated membrane (MAM) and endoplasmic reticulum (ER) per se.
PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria- associated membrane (MAM).
TISSUE SPECIFICITY: Highly expressed in testis. Detected at lower levels in kidney and heart.
DISRUPTION PHENOTYPE: Null mice exhibit a reduction of more than 95% in serine exchange in testis and approximately 90% reduction in brain and liver. Testis weight is reduced and some animals are infertile. Elimination of either Pss1 or Pss2, but not both, is compatible with mouse viability. Mice can tolerate as little as 10% serine-exchange activity and are viable with small amounts of phosphatidylserine and phosphatidylethanolamine content.
SIMILARITY: Belongs to the phosphatidyl serine synthase family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.10116-0.397 Picture PostScript Text
3' UTR -672.702086-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004277 - PSS

Pfam Domains:
PF03034 - Phosphatidyl serine synthase

SCOP Domains:
48350 - GTPase activation domain, GAP

ModBase Predicted Comparative 3D Structure on Q9Z1X2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0006629 lipid metabolic process
GO:0006659 phosphatidylserine biosynthetic process
GO:0008654 phospholipid biosynthetic process

Cellular Component:
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  LF196687 - JP 2014500723-A/4190: Polycomb-Associated Non-Coding RNAs.
AK036368 - Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630061G10 product:phosphatidylserine synthase 2, full insert sequence.
AK031906 - Mus musculus adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330442L20 product:phosphatidylserine synthase 2, full insert sequence.
AK048026 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130030N20 product:phosphatidylserine synthase 2, full insert sequence.
AK081275 - Mus musculus adult male corpus striatum cDNA, RIKEN full-length enriched library, clone:C030041I20 product:phosphatidylserine synthase 2, full insert sequence.
AK021249 - Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430041K09 product:phosphatidylserine synthase 2, full insert sequence.
AK032686 - Mus musculus 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:6530422L18 product:phosphatidylserine synthase 2, full insert sequence.
AK137415 - Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630050J16 product:phosphatidylserine synthase 2, full insert sequence.
BC053517 - Mus musculus phosphatidylserine synthase 2, mRNA (cDNA clone MGC:54595 IMAGE:6315175), complete cds.
AF099053 - Mus musculus phosphatidylserine synthase-2 mRNA, complete cds.
BC009013 - Mus musculus phosphatidylserine synthase 2, mRNA (cDNA clone IMAGE:3583796), partial cds.
AK218376 - Mus musculus cDNA, clone:Y2G0145A04, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000026568, based on BLAT search.
AK054435 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330025E04 product:inferred: phosphatidylserine synthase 2 / phosphatidylserine synthase-2, full insert sequence.
LF296599 - JP 2014500723-A/104102: Polycomb-Associated Non-Coding RNAs.
LF296600 - JP 2014500723-A/104103: Polycomb-Associated Non-Coding RNAs.
AK052215 - Mus musculus 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330009G23 product:inferred: phosphatidylserine synthase 2, full insert sequence.
AK188787 - Mus musculus cDNA, clone:Y0G0146H13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000026568, based on BLAT search.
LF296601 - JP 2014500723-A/104104: Polycomb-Associated Non-Coding RNAs.
LF296602 - JP 2014500723-A/104105: Polycomb-Associated Non-Coding RNAs.
MA432264 - JP 2018138019-A/4190: Polycomb-Associated Non-Coding RNAs.
MA532176 - JP 2018138019-A/104102: Polycomb-Associated Non-Coding RNAs.
MA532177 - JP 2018138019-A/104103: Polycomb-Associated Non-Coding RNAs.
MA532178 - JP 2018138019-A/104104: Polycomb-Associated Non-Coding RNAs.
MA532179 - JP 2018138019-A/104105: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00564 - Glycerophospholipid metabolism
mmu01100 - Metabolic pathways

BioCyc Knowledge Library
PHOSLIPSYN-PWY - phospholipid biosynthesis I
PWY-5669 - phosphatidylethanolamine biosynthesis I

Reactome (by CSHL, EBI, and GO)

Protein Q9Z1X2 (Reactome details) participates in the following event(s):

R-MMU-1483089 PE is converted to PS by PTDSS2
R-MMU-1483101 Synthesis of PS
R-MMU-1483206 Glycerophospholipid biosynthesis
R-MMU-1483257 Phospholipid metabolism
R-MMU-556833 Metabolism of lipids
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NM_013782, Pss2, PTSS2_MOUSE, Q8BHL2, Q8CCI8, Q8CCY7, Q922A1, Q9CY68, Q9Z1X2, uc009kjq.1, uc009kjq.2
UCSC ID: uc009kjq.2
RefSeq Accession: NM_013782
Protein: Q9Z1X2 (aka PTSS2_MOUSE or PSS2_MOUSE)
CCDS: CCDS22001.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.