ID:PTSS2_MOUSE DESCRIPTION: RecName: Full=Phosphatidylserine synthase 2; Short=PSS-2; Short=PtdSer synthase 2; EC=18.104.22.168; AltName: Full=Serine-exchange enzyme II; FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine. CATALYTIC ACTIVITY: L-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine. ENZYME REGULATION: Almost complete inhibition by ethanolamine in both the mitochondria-associated membrane (MAM) and endoplasmic reticulum (ER) per se. PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria- associated membrane (MAM). TISSUE SPECIFICITY: Highly expressed in testis. Detected at lower levels in kidney and heart. DISRUPTION PHENOTYPE: Null mice exhibit a reduction of more than 95% in serine exchange in testis and approximately 90% reduction in brain and liver. Testis weight is reduced and some animals are infertile. Elimination of either Pss1 or Pss2, but not both, is compatible with mouse viability. Mice can tolerate as little as 10% serine-exchange activity and are viable with small amounts of phosphatidylserine and phosphatidylethanolamine content. SIMILARITY: Belongs to the phosphatidyl serine synthase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48350 - GTPase activation domain, GAP
ModBase Predicted Comparative 3D Structure on Q9Z1X2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.