ID:CNGA4_MOUSE DESCRIPTION: RecName: Full=Cyclic nucleotide-gated cation channel alpha-4; AltName: Full=Cyclic nucleotide-gated channel alpha-4; Short=CNG channel alpha-4; Short=CNG-4; Short=CNG4; FUNCTION: Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. ENZYME REGULATION: Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding (By similarity). SUBUNIT: Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide- gated (CNG) channel of olfactory neurons (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. SIMILARITY: Contains 1 cyclic nucleotide-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3UW12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0007608 sensory perception of smell GO:0034220 ion transmembrane transport GO:0042391 regulation of membrane potential GO:0050896 response to stimulus GO:0051290 protein heterotetramerization GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport GO:0098655 cation transmembrane transport
Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0017071 intracellular cyclic nucleotide activated cation channel complex GO:0043204 perikaryon
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04740 - Olfactory transduction
Reactome (by CSHL, EBI, and GO)
Protein Q3UW12 (Reactome details) participates in the following event(s):
R-MMU-5620914 ARF4:GTP binds VxPx-motifs of membrane proteins R-MMU-5623519 RAB3IP and RAB8A bind to the ciliary targeting complex R-MMU-5623513 ASAP1 stimulates GTPase activity of ARF4 R-MMU-5620921 ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex R-MMU-5623521 RAB3IP stimulates nucleotide exchange on RAB8A R-MMU-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex R-MMU-5620916 VxPx cargo-targeting to cilium R-MMU-5620920 Cargo trafficking to the periciliary membrane R-MMU-5617833 Cilium Assembly R-MMU-1852241 Organelle biogenesis and maintenance
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