Mouse Gene Tubb4b (ENSMUST00000043584.4) Description and Page Index
  Description: Mus musculus tubulin, beta 4B class IVB (Tubb4b), mRNA. (from RefSeq NM_146116)
Gencode Transcript: ENSMUST00000043584.4
Gencode Gene: ENSMUSG00000036752.4
Transcript (Including UTRs)
   Position: mm10 chr2:25,222,160-25,224,702 Size: 2,543 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr2:25,222,308-25,224,590 Size: 2,283 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:25,222,160-25,224,702)mRNA (may differ from genome)Protein (445 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tubulin beta-4B chain; AltName: Full=Tubulin beta-2C chain;
FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
SUBUNIT: Dimer of alpha and beta chains.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
DOMAIN: The highly acidic C-terminal region may bind cations such as calcium.
PTM: Some glutamate residues at the C-terminus are either polyglutamylated or polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they are regulate the assembly and dynamics of axonemal microtubules.
SIMILARITY: Belongs to the tubulin family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.70112-0.292 Picture PostScript Text
3' UTR -36.00148-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013838 - Beta-tubulin_BS
IPR002453 - Beta_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain

SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like

ModBase Predicted Comparative 3D Structure on P68372
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBank EnsemblEnsembl  
Protein Sequence  Protein Sequence  
Alignment  Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003725 double-stranded RNA binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

Biological Process:
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0043209 myelin sheath
GO:0045298 tubulin complex

-  Descriptions from all associated GenBank mRNAs
  BC022919 - Mus musculus tubulin, beta 2C, mRNA (cDNA clone MGC:28623 IMAGE:4221189), complete cds.
BC005547 - Mus musculus tubulin, beta 2C, mRNA (cDNA clone MGC:6713 IMAGE:3585500), complete cds.
BC083319 - Mus musculus tubulin, beta 2C, mRNA (cDNA clone MGC:101937 IMAGE:5699674), complete cds.
AK015901 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930526G20 product:TUBULIN BETA-2 CHAIN homolog [Homo sapiens], full insert sequence.
AK146587 - Mus musculus cDNA, RIKEN full-length enriched library, clone:I920030A10 product:Tubulin beta-2 chain homolog [Homo sapiens], full insert sequence.
AK194925 - Mus musculus cDNA, clone:Y1G0116N11, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060285, based on BLAT search.
AK214079 - Mus musculus cDNA, clone:Y2G0130I20, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060285, based on BLAT search.
AK002568 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610011P07 product:tubulin, beta, 2 [Mus musculus], full insert sequence.
AK076895 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930542G03 product:TUBULIN BETA-2 CHAIN homolog [Homo sapiens], full insert sequence.
AK167022 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0028A18 product:Tubulin beta-2 chain homolog [Homo sapiens], full insert sequence.
AB345039 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA10240, complete sequence.
AK195017 - Mus musculus cDNA, clone:Y1G0117C10, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043584, based on BLAT search.
AK006924 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700069N23 product:TUBULIN BETA-2 CHAIN homolog [Homo sapiens], full insert sequence.
AK196744 - Mus musculus cDNA, clone:Y1G0122M19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043584, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04145 - Phagosome
mmu04540 - Gap junction

Reactome (by CSHL, EBI, and GO)

Protein P68372 (Reactome details) participates in the following event(s):

R-MMU-380272 Plk1-mediated phosphorylation of Nlp
R-MMU-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-MMU-380294 Loss of C-Nap-1 from centrosomes
R-MMU-380311 Recruitment of Plk1 to centrosomes
R-MMU-380303 Dissociation of Phospho-Nlp from the centrosome
R-MMU-5626220 C2CD3 binds the mother centriole
R-MMU-6798751 Exocytosis of azurophil granule lumen proteins
R-MMU-380508 Translocation of NuMA to the centrosomes
R-MMU-2574845 AJUBA binds centrosome-associated AURKA
R-MMU-8853405 TPX2 binds AURKA at centrosomes
R-MMU-3000319 BORA binds PLK1 and AURKA
R-MMU-2574840 AJUBA facilitates AURKA autophosphorylation
R-MMU-3000310 AURKA phosphorylates PLK1
R-MMU-5626681 Recruitment of transition zone proteins
R-MMU-5626227 CP110 and CEP97 dissociate from the centriole
R-MMU-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
R-MMU-380316 Association of NuMA with microtubules
R-MMU-8853419 TPX2 promotes AURKA autophosphorylation
R-MMU-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
R-MMU-5626228 The distal appendage proteins recruit TTBK2
R-MMU-5626699 MARK4 binds ODF2 in the centriole
R-MMU-5617816 RAB3IP stimulates nucleotide exchange on RAB8A
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-6798695 Neutrophil degranulation
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-8854518 AURKA Activation by TPX2
R-MMU-380287 Centrosome maturation
R-MMU-5617833 Cilium Assembly
R-MMU-168249 Innate Immune System
R-MMU-68877 Mitotic Prometaphase
R-MMU-69275 G2/M Transition
R-MMU-1852241 Organelle biogenesis and maintenance
R-MMU-168256 Immune System
R-MMU-68886 M Phase
R-MMU-453274 Mitotic G2-G2/M phases
R-MMU-69278 Cell Cycle (Mitotic)
R-MMU-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: NM_146116, P05217, P68372, Q3TKF0, Q3UJ73, Q99JZ6, TBB4B_MOUSE, Tubb2c, uc008iqs.1, uc008iqs.2, uc008iqs.3
UCSC ID: uc008iqs.3
RefSeq Accession: NM_146116
Protein: P68372 (aka TBB4B_MOUSE)
CCDS: CCDS15753.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.