Mouse Gene Tmem109 (ENSMUST00000038128.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus transmembrane protein 109 (Tmem109), mRNA. (from RefSeq NM_134142)
Gencode Transcript: ENSMUST00000038128.14
Gencode Gene: ENSMUSG00000034659.14
Transcript (Including UTRs)
   Position: mm10 chr19:10,870,660-10,882,001 Size: 11,342 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr19:10,871,758-10,874,478 Size: 2,721 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:10,870,660-10,882,001)mRNA (may differ from genome)Protein (243 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TM109_MOUSE
DESCRIPTION: RecName: Full=Transmembrane protein 109; AltName: Full=Mitsugumin-23; Short=Mg23; Flags: Precursor;
SUBCELLULAR LOCATION: Nucleus outer membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi- pass membrane protein (By similarity). Sarcoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.00358-0.291 Picture PostScript Text
3' UTR -395.701098-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF02861 - Clp amino terminal domain, pathogenicity island component
PF14965 - Negative regulator of p53/TP53

ModBase Predicted Comparative 3D Structure on Q3UBX0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005244 voltage-gated ion channel activity
GO:0005515 protein binding

Biological Process:
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0060548 negative regulation of cell death
GO:0071480 cellular response to gamma radiation

Cellular Component:
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0031965 nuclear membrane
GO:0033017 sarcoplasmic reticulum membrane


-  Descriptions from all associated GenBank mRNAs
  LF201678 - JP 2014500723-A/9181: Polycomb-Associated Non-Coding RNAs.
BC023901 - Mus musculus transmembrane protein 109, mRNA (cDNA clone MGC:38146 IMAGE:5321274), complete cds.
BC025033 - Mus musculus transmembrane protein 109, mRNA (cDNA clone MGC:36969 IMAGE:4947460), complete cds.
BC025815 - Mus musculus transmembrane protein 109, mRNA (cDNA clone MGC:37801 IMAGE:5097938), complete cds.
BC022997 - Mus musculus transmembrane protein 109, mRNA (cDNA clone MGC:38921 IMAGE:5362560), complete cds.
AK049148 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330007I17 product:similar to MITSUGUMIN 23 [Oryctolagus cuniculus], full insert sequence.
AK165990 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730027D14 product:similar to Mitsugumin 23 [Oryctolagus cuniculus], full insert sequence.
AK150779 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830015F08 product:hypothetical Leucine-rich region profile containing protein, full insert sequence.
AK151850 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830040K08 product:similar to Mitsugumin 23 [Oryctolagus cuniculus], full insert sequence.
AK152419 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830071C05 product:hypothetical Leucine-rich region profile containing protein, full insert sequence.
MA437255 - JP 2018138019-A/9181: Polycomb-Associated Non-Coding RNAs.
AK196648 - Mus musculus cDNA, clone:Y1G0122H17, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000038128, based on BLAT search.
AK003502 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110006I15 product:inferred: mitsugumin 23 {Oryctolagus cuniculus}, full insert sequence.
AK211175 - Mus musculus cDNA, clone:Y2G0120O07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000038128, based on BLAT search.
AK202892 - Mus musculus cDNA, clone:Y1G0143B02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000038128, based on BLAT search.
AK194142 - Mus musculus cDNA, clone:Y1G0114G24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000038128, based on BLAT search.
LF257324 - JP 2014500723-A/64827: Polycomb-Associated Non-Coding RNAs.
AK180863 - Mus musculus cDNA, clone:Y0G0116C14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000038128, based on BLAT search.
AK189371 - Mus musculus cDNA, clone:Y0G0148O19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000038128, based on BLAT search.
LF257325 - JP 2014500723-A/64828: Polycomb-Associated Non-Coding RNAs.
LF257326 - JP 2014500723-A/64829: Polycomb-Associated Non-Coding RNAs.
LF257328 - JP 2014500723-A/64831: Polycomb-Associated Non-Coding RNAs.
MA492901 - JP 2018138019-A/64827: Polycomb-Associated Non-Coding RNAs.
MA492902 - JP 2018138019-A/64828: Polycomb-Associated Non-Coding RNAs.
MA492903 - JP 2018138019-A/64829: Polycomb-Associated Non-Coding RNAs.
MA492905 - JP 2018138019-A/64831: Polycomb-Associated Non-Coding RNAs.
AK215166 - Mus musculus cDNA, clone:Y2G0134C24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000038128, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_134142, Q3UBX0, Q8R006, TM109_MOUSE, uc008gre.1, uc008gre.2, uc008gre.3, uc008gre.4
UCSC ID: uc008gre.4
RefSeq Accession: NM_134142
Protein: Q3UBX0 (aka TM109_MOUSE)
CCDS: CCDS29590.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.