Mouse Gene Il17b (ENSMUST00000025471.3) Description and Page Index
  Description: Mus musculus interleukin 17B (Il17b), mRNA. (from RefSeq NM_019508)
Gencode Transcript: ENSMUST00000025471.3
Gencode Gene: ENSMUSG00000024578.3
Transcript (Including UTRs)
   Position: mm10 chr18:61,687,935-61,692,538 Size: 4,604 Total Exon Count: 3 Strand: +
Coding Region
   Position: mm10 chr18:61,687,984-61,692,437 Size: 4,454 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:61,687,935-61,692,538)mRNA (may differ from genome)Protein (180 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: IL17B_MOUSE
DESCRIPTION: RecName: Full=Interleukin-17B; Short=IL-17B; AltName: Full=Cytokine CX1; AltName: Full=Cytokine-like protein ZCYTO7; AltName: Full=Neuronal interleukin-17-related factor; Flags: Precursor;
FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 (By similarity).
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the IL-17 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.0049-0.449 Picture PostScript Text
3' UTR -19.60101-0.194 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010345 - Interleukin-17
IPR020440 - Interleukin-17_chordata

Pfam Domains:
PF06083 - Interleukin-17

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on Q9QXT6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005125 cytokine activity

Biological Process:
GO:0006954 inflammatory response
GO:0010469 regulation of receptor activity
GO:0030593 neutrophil chemotaxis
GO:1900017 positive regulation of cytokine production involved in inflammatory response

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  AK003506 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110006O16 product:interleukin 17B, full insert sequence.
AF184970 - Mus musculus cytokine-like protein ZCYTO7 (Zcyto7) mRNA, complete cds.
AF218726 - Mus musculus neuronal interleukin-17 related factor mRNA, complete cds.
BC002271 - Mus musculus interleukin 17B, mRNA (cDNA clone MGC:7662 IMAGE:3496106), complete cds.
AF250308 - Mus musculus cytokine CX1 precusor mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04060 - Cytokine-cytokine receptor interaction

-  Other Names for This Gene
  Alternate Gene Symbols: IL17B_MOUSE, Nirf, NM_019508, Q99MY3, Q9CTI4, Q9QXT6, uc008fcl.1, uc008fcl.2, Zcyto7
UCSC ID: uc008fcl.2
RefSeq Accession: NM_019508
Protein: Q9QXT6 (aka IL17B_MOUSE or I17B_MOUSE)
CCDS: CCDS29286.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.