ID:THOC6_MOUSE DESCRIPTION: RecName: Full=THO complex subunit 6 homolog; AltName: Full=WD repeat-containing protein 58; FUNCTION: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex (By similarity). SUBUNIT: Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex (By similarity). SIMILARITY: Belongs to the WD repeat THOC6 family. SIMILARITY: Contains 7 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5U4D9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu03013 - RNA transport
Reactome (by CSHL, EBI, and GO)
Protein Q5U4D9 (Reactome details) participates in the following event(s):
R-MMU-72180 Cleavage of mRNA at the 3'-end R-MMU-72185 mRNA polyadenylation R-MMU-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-MMU-72187 mRNA 3'-end processing R-MMU-109688 Cleavage of Growing Transcript in the Termination Region R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA R-MMU-73856 RNA Polymerase II Transcription Termination R-MMU-72202 Transport of Mature Transcript to Cytoplasm R-MMU-8953854 Metabolism of RNA R-MMU-73857 RNA Polymerase II Transcription R-MMU-74160 Gene expression (Transcription)
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