ID:SE1L1_MOUSE DESCRIPTION: RecName: Full=Protein sel-1 homolog 1; AltName: Full=Suppressor of lin-12-like protein 1; Short=Sel-1L; Flags: Precursor; FUNCTION: May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). SUBUNIT: Part of a complex containing SEL1L, SYVN1 and DERL2. May form a complex with ERLEC1, HSPA5, OS9, and SYVN1. Interacts with FOXRED2 and EDEM1 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). PTM: N-glycosylated (By similarity). SIMILARITY: Belongs to the sel-1 family. SIMILARITY: Contains 1 fibronectin type-II domain. SIMILARITY: Contains 11 Sel1-like repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Z2G6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006641 triglyceride metabolic process GO:0007219 Notch signaling pathway GO:0009306 protein secretion GO:0030970 retrograde protein transport, ER to cytosol GO:0034976 response to endoplasmic reticulum stress GO:0036503 ERAD pathway
AK220502 - Mus musculus mRNA for mKIAA4137 protein. AK160936 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:4021401G01 product:Sel1 (suppressor of lin-12) 1 homolog (C. elegans), full insert sequence. BC049959 - Mus musculus sel-1 suppressor of lin-12-like (C. elegans), mRNA (cDNA clone IMAGE:4923124), partial cds. AK008076 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010003M20 product:unclassifiable, full insert sequence. AF063095 - Mus musculus SELlL (Sel1l) mRNA, complete cds. BC057452 - Mus musculus sel-1 suppressor of lin-12-like (C. elegans), mRNA (cDNA clone IMAGE:3965128), partial cds. BC026816 - Mus musculus sel-1 suppressor of lin-12-like (C. elegans), mRNA (cDNA clone MGC:25250 IMAGE:4457637), complete cds. AK146022 - Mus musculus 14 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530024L02 product:Sel1 (suppressor of lin-12) 1 homolog (C. elegans), full insert sequence. AK005023 - Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clone:1300016D21 product:Sel1 (suppressor of lin-12) 1 homolog (C. elegans), full insert sequence. AK161546 - Mus musculus adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330403H04 product:Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L) homolog [Mus musculus], full insert sequence. AK160420 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700080G14 product:Sel1 (suppressor of lin-12) 1 homolog (C. elegans), full insert sequence. AK005544 - Mus musculus adult female placenta cDNA, RIKEN full-length enriched library, clone:1600026C08 product:Sel1 (suppressor of lin-12) 1 homolog (C. elegans), full insert sequence. AK158190 - Mus musculus adult inner ear cDNA, RIKEN full-length enriched library, clone:F930039K02 product:unclassifiable, full insert sequence.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04141 - Protein processing in endoplasmic reticulum
Reactome (by CSHL, EBI, and GO)
Protein Q9Z2G6 (Reactome details) participates in the following event(s):
R-MMU-5362441 C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane R-MMU-5362459 VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol R-MMU-8866551 CFTR binds components of the ERAD machinery for ubiquitination and degradation R-MMU-8866542 VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol R-MMU-1022127 OS9:SEL1:ERAD E3 ligase:DERL2 transports Ub-unfolded protein:(GlcNAc)2 (Man)9-5 from ERQC to cytosol R-MMU-8867288 OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 R-MMU-5362412 SYVN1 ubiquitinates Hh C-terminal fragments R-MMU-8866546 RNF5 and RNF185 ubiquitinate misfolded CFTR R-MMU-5358346 Hedgehog ligand biogenesis R-MMU-382556 ABC-family proteins mediated transport R-MMU-901032 ER Quality Control Compartment (ERQC) R-MMU-5358351 Signaling by Hedgehog R-MMU-382551 Transport of small molecules R-MMU-901042 Calnexin/calreticulin cycle R-MMU-162582 Signal Transduction R-MMU-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-MMU-446203 Asparagine N-linked glycosylation R-MMU-597592 Post-translational protein modification R-MMU-392499 Metabolism of proteins